ECH1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ECH1_MOUSE
• UniProt AC: O35459
• Protein Name: Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
• Gene Name: Ech1
• Organism: Mus musculus (Mouse).
• Sequence Length: 327
• Subcellular Localization: Mitochondrion. Peroxisome.
• Protein Description: Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA..
• Protein Sequence: MATAMTVSSKLRGLLMQQLRGTSQLYFNISLRSLSSSAQEASKRAPEEVSDHNYESIQVTSAQKHVLHVQLNRPEKRNAMNRAFWRELVECFQKISKDSDCRAVVVSGAGKMFTSGIDLMDMASELMQPSGDDAARIAWYLRDLISKYQKTFTVIEKCPKPVIAAIHGGCIGGGVDLVSACDIRYCTQDAFFQIKEVDMGLAADVGTLQRLPKVIGNQSLVNELTFSARKMMADEALDSGLVSRVFQDKDAMLNAAFALAADISSKSPVAVQGSKINLIYSRDHSVDESLDYMATWNMSMLQTQDIIKSVQAAMEKRDTKSITFSKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATAMTVSSK -----CCCCHHHHHH	18.70	29233185
6	Phosphorylation	--MATAMTVSSKLRG --CCCCHHHHHHHHH	18.12	21930439
8	Phosphorylation	MATAMTVSSKLRGLL CCCCHHHHHHHHHHH	16.76	29233185
9	Phosphorylation	ATAMTVSSKLRGLLM CCCHHHHHHHHHHHH	31.23	21930439
42	Phosphorylation	SSSAQEASKRAPEEV CHHHHHHHHHCCHHH	23.17	25521595
76	Acetylation	VQLNRPEKRNAMNRA EECCCHHHHCHHHHH	54.35	23864654
91	S-nitrosocysteine	FWRELVECFQKISKD HHHHHHHHHHHHCCC	3.23	-
91	S-nitrosylation	FWRELVECFQKISKD HHHHHHHHHHHHCCC	3.23	21278135
94	Acetylation	ELVECFQKISKDSDC HHHHHHHHHCCCCCC	28.79	23864654
96	Phosphorylation	VECFQKISKDSDCRA HHHHHHHCCCCCCCE	37.13	25177544
97	Acetylation	ECFQKISKDSDCRAV HHHHHHCCCCCCCEE	65.80	23864654
97	Succinylation	ECFQKISKDSDCRAV HHHHHHCCCCCCCEE	65.80	26388266
99	Phosphorylation	FQKISKDSDCRAVVV HHHHCCCCCCCEEEE	42.20	25177544
101	S-nitrosylation	KISKDSDCRAVVVSG HHCCCCCCCEEEECC	3.31	21278135
101	S-nitrosocysteine	KISKDSDCRAVVVSG HHCCCCCCCEEEECC	3.31	-
107	Phosphorylation	DCRAVVVSGAGKMFT CCCEEEECCCHHHHC	16.00	25177544
111	Succinylation	VVVSGAGKMFTSGID EEECCCHHHHCCCCC	30.24	23806337
111	Acetylation	VVVSGAGKMFTSGID EEECCCHHHHCCCCC	30.24	23806337
147	Ubiquitination	YLRDLISKYQKTFTV HHHHHHHHHHHHEEH	44.71	22790023
147	Acetylation	YLRDLISKYQKTFTV HHHHHHHHHHHHEEH	44.71	23576753
150	Ubiquitination	DLISKYQKTFTVIEK HHHHHHHHHEEHHHC	42.38	-
150	Acetylation	DLISKYQKTFTVIEK HHHHHHHHHEEHHHC	42.38	23864654
150	Succinylation	DLISKYQKTFTVIEK HHHHHHHHHEEHHHC	42.38	26388266
186	S-nitrosocysteine	SACDIRYCTQDAFFQ HHCCEEEECCCCCCC	1.66	-
186	S-nitrosylation	SACDIRYCTQDAFFQ HHCCEEEECCCCCCC	1.66	21278135
195	Succinylation	QDAFFQIKEVDMGLA CCCCCCEEECCCCCC	40.68	26388266
230	Ubiquitination	ELTFSARKMMADEAL HHHHHHHHHHHHHHH	32.51	-
230	Succinylation	ELTFSARKMMADEAL HHHHHHHHHHHHHHH	32.51	23806337
230	Glutarylation	ELTFSARKMMADEAL HHHHHHHHHHHHHHH	32.51	24703693
230	Malonylation	ELTFSARKMMADEAL HHHHHHHHHHHHHHH	32.51	26320211
230	Acetylation	ELTFSARKMMADEAL HHHHHHHHHHHHHHH	32.51	23806337
230	Succinylation	ELTFSARKMMADEAL HHHHHHHHHHHHHHH	32.51	-
267	Phosphorylation	AADISSKSPVAVQGS HHHHHCCCCCEECCC	26.93	-
275	Ubiquitination	PVAVQGSKINLIYSR CCEECCCEEEEEEEC	42.30	22790023
316	Succinylation	SVQAAMEKRDTKSIT HHHHHHHHCCCCCCE	42.35	23806337
316	Succinylation	SVQAAMEKRDTKSIT HHHHHHHHCCCCCCE	42.35	-
316	Acetylation	SVQAAMEKRDTKSIT HHHHHHHHCCCCCCE	42.35	23864654
316	Glutarylation	SVQAAMEKRDTKSIT HHHHHHHHCCCCCCE	42.35	24703693
320	Acetylation	AMEKRDTKSITFSKL HHHHCCCCCCEECCC	44.12	23201123
326	Acetylation	TKSITFSKL------ CCCCEECCC------	54.76	21728379

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ECH1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ECH1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ECH1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ECH1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.