EAF6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EAF6_MOUSE
• UniProt AC: Q2VPQ9
• Protein Name: Chromatin modification-related protein MEAF6
• Gene Name: Meaf6
• Organism: Mus musculus (Mouse).
• Sequence Length: 191
• Subcellular Localization: Nucleus, nucleolus . Chromosome, centromere, kinetochore .
• Protein Description: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity)..
• Protein Sequence: MAMHNKTAPPQIPDTRRELAELVKRKQELAETLANLERQIYAFEGSYLEDTQMYGNIIRGWDRYLTNQKNSNSKNDRRNRKFKEAERLFSKSSVTSAAAVSALAGVQDQLIEKREPGSGTESDTSPDFHNQENEPAQEDPEDLDGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAMHNKTAP ------CCCCCCCCC	14.13	23806337
6	Acetylation	--MAMHNKTAPPQIP --CCCCCCCCCCCCC	31.24	23806337
26	Ubiquitination	LAELVKRKQELAETL HHHHHHHHHHHHHHH	42.27	-
69	Acetylation	DRYLTNQKNSNSKND HHHHHCCCCCCCHHH	65.50	23806337
71	Phosphorylation	YLTNQKNSNSKNDRR HHHCCCCCCCHHHHH	49.90	25338131
73	Phosphorylation	TNQKNSNSKNDRRNR HCCCCCCCHHHHHHH	32.43	25338131
74	Acetylation	NQKNSNSKNDRRNRK CCCCCCCHHHHHHHH	68.09	23806337
90	Phosphorylation	KEAERLFSKSSVTSA HHHHHHHCCCHHHHH	35.90	20139300
91	Acetylation	EAERLFSKSSVTSAA HHHHHHCCCHHHHHH	39.14	22826441
92	Phosphorylation	AERLFSKSSVTSAAA HHHHHCCCHHHHHHH	28.92	20139300
93	Phosphorylation	ERLFSKSSVTSAAAV HHHHCCCHHHHHHHH	32.90	20139300
96	Phosphorylation	FSKSSVTSAAAVSAL HCCCHHHHHHHHHHH	17.47	20139300
118	Phosphorylation	IEKREPGSGTESDTS HHHCCCCCCCCCCCC	53.94	21082442
120	Phosphorylation	KREPGSGTESDTSPD HCCCCCCCCCCCCCC	33.73	21082442
122	Phosphorylation	EPGSGTESDTSPDFH CCCCCCCCCCCCCCC	46.13	21082442
124	Phosphorylation	GSGTESDTSPDFHNQ CCCCCCCCCCCCCCC	51.98	22802335
125	Phosphorylation	SGTESDTSPDFHNQE CCCCCCCCCCCCCCC	27.71	22802335
146	Phosphorylation	DPEDLDGSVQGVKPQ CHHHCCCCCCCCCCC	15.78	25159016
182 (in isoform 2)	Phosphorylation	-	46.39	26824392
185 (in isoform 2)	Phosphorylation	-	74.68	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EAF6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EAF6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EAF6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EAF6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.