| UniProt ID | EAA1_RAT | |
|---|---|---|
| UniProt AC | P24942 | |
| Protein Name | Excitatory amino acid transporter 1 | |
| Gene Name | Slc1a3 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 543 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. [PubMed: 1279699] | |
| Protein Sequence | MTKSNGEEPRMGSRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVSAVIVGTILGFALRPYKMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMYREGKIVQVTAADAFLDLIRNMFPPNLVEACFKQFKTSYEKRSFKVPIQANETLLGAVINNVSEAMETLTRIREEMVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPLGILFLIAGKILEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFIAQVNNFDLNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNEPEKPVADSETKM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 79 | Acetylation | KMSYREVKYFSFPGE CCCCCCCCCCCCCHH | 35.51 | 2643075 | |
| 186 | S-nitrosocysteine | PPNLVEACFKQFKTS CHHHHHHHHHHHHCC | 2.50 | - | |
| 186 | S-nitrosylation | PPNLVEACFKQFKTS CHHHHHHHHHHHHCC | 2.50 | 22178444 | |
| 188 | Acetylation | NLVEACFKQFKTSYE HHHHHHHHHHHCCCC | 55.50 | 2643071 | |
| 512 | Phosphorylation | RDVEMGNSVIEENEM CCCCCCCCHHCCCCC | 20.81 | 30411139 | |
| 521 | Acetylation | IEENEMKKPYQLIAQ HCCCCCCCCEEEECC | 47.88 | 22902405 | |
| 521 | Ubiquitination | IEENEMKKPYQLIAQ HCCCCCCCCEEEECC | 47.88 | - | |
| 523 | Phosphorylation | ENEMKKPYQLIAQDN CCCCCCCEEEECCCC | 25.49 | 27097102 | |
| 534 | Acetylation | AQDNEPEKPVADSET CCCCCCCCCCCCCCC | 56.35 | 22902405 | |
| 534 | Ubiquitination | AQDNEPEKPVADSET CCCCCCCCCCCCCCC | 56.35 | - | |
| 539 | Phosphorylation | PEKPVADSETKM--- CCCCCCCCCCCC--- | 37.11 | 27097102 | |
| 541 | Phosphorylation | KPVADSETKM----- CCCCCCCCCC----- | 36.04 | 27097102 | |
| 542 | Ubiquitination | PVADSETKM------ CCCCCCCCC------ | 38.26 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EAA1_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EAA1_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EAA1_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of EAA1_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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