E2AK4_MOUSE - dbPTM
E2AK4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID E2AK4_MOUSE
UniProt AC Q9QZ05
Protein Name eIF-2-alpha kinase GCN2 {ECO:0000305}
Gene Name Eif2ak4 {ECO:0000312|MGI:MGI:1353427}
Organism Mus musculus (Mouse).
Sequence Length 1648
Subcellular Localization Cytoplasm .
Protein Description Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability. [PubMed: 10504407]
Protein Sequence MAGGRGASGRGRAEPQESYSQRQDHELQALEAIYGSDFQDLRPDARGRVREPPEINLVLYPQGLAGEEVYVQVELQVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSHLEELAKKQCGEVMIFELAHHVQSFLSEHNKPPPKSFHEEMLERQAQEKQQRLLEARRKEEQEQREILHEIQRRKEEIKEEKKRKEMAKQERLEITSLTNQDYASKRDPAGHRAAAILHGGSPDFVGNGKARTYSSGRSRRERQYSVCSGEPSPGSCDILHFSVGSPDQLMVHKGRCVGSDEQLGKVVYNALETATGSFVLLHEWVLQWQKMGPCLTSQEKEKIDKCKRQIQGAETEFSSLVKLSHPNIVRYFAMNSREEEDSIVIDILAEHVSGISLATHLSHSGPVPAHQLRKYTAQLLAGLDYLHSNSVVHKVLSASSVLVDAEGTVKITDYSISKRLADICKEDVFEQARVRFSDSALPYKTGKKGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINPQPKLPLVEQSPEDSGGQDYIETVIPSNQLPSAAFFSETQKQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLLSRLHHENIVRYYNAWIERHERPAVPGTPPPDCTPQAQDSPATCGKTSGDTEELGSVEAAAPPPILSSSVEWSTSAERSTSTRFPVTGQDSSSDEEDEDERDGVFSQSFLPASDSDSDIIFDNEDENSKSQNQDEDCNQKDGSHEIEPSVTAEAVHYLYIQMEYCEKSTLRDTIDQGLFRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFTAEGKQDDQAGDGVIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPDDFDDGEHTKQKSVISWLLNHDPAKRPTAMELLKSELLPPPQMEESELHEVLHHTLANIDGKAYRTMMSQIFCQHISPAIDYTYDSDILKGNFLIRTAKIQQLVCETIVRVFKRHGAVQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRVPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTTNSSLPTAETIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVYVILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIEQKGDLQDLTPTINSLIKQKTGVAQLVKYSLKDLEDVVGLLKKLGVKLQVSINLGLVYKVQQHTGIIFQFLAFSKRRQRVVPEILAAGGRYDLLIPKFRGPQTVGPVPTAVGVSIAIDKIFAAVLNMEEPVTVSSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLESDLVDHVMQKLRTKVGDERNFRDASDNLAVQTLKGSFSNASGLFEIHGTTVVPNVIVLAPEKLSASTRRRHEIQVQTRLQTTLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVCDEIYNIKVEKKVSVLFLYSYRDDYYRILF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
230PhosphorylationAAILHGGSPDFVGNG
HHHHCCCCCCCCCCC		26.3626745281
254PhosphorylationSRRERQYSVCSGEPS
CHHHEEEEEECCCCC		14.3322322096
261PhosphorylationSVCSGEPSPGSCDIL
EEECCCCCCCCCCEE		37.28-
437PhosphorylationVLVDAEGTVKITDYS
EEECCCCCEEEEECC		15.33-
466PhosphorylationEQARVRFSDSALPYK
HHHHHHCCCCCCCCC		21.7925338131
550PhosphorylationKLPLVEQSPEDSGGQ
CCCCCCCCCCCCCCC		19.4221743459
554PhosphorylationVEQSPEDSGGQDYIE
CCCCCCCCCCCCCEE		43.0626824392
559PhosphorylationEDSGGQDYIETVIPS
CCCCCCCCEEEEECC		7.8621189417
562PhosphorylationGGQDYIETVIPSNQL
CCCCCEEEEECCCCC		17.7425293948
566PhosphorylationYIETVIPSNQLPSAA
CEEEEECCCCCCCCC		26.5325293948
571PhosphorylationIPSNQLPSAAFFSET
ECCCCCCCCCCCHHH		40.6025293948
576PhosphorylationLPSAAFFSETQKQFS
CCCCCCCHHHHHHHH		33.0325293948
578PhosphorylationSAAFFSETQKQFSRY
CCCCCHHHHHHHHHH		39.6125293948
666PhosphorylationERPAVPGTPPPDCTP
CCCCCCCCCCCCCCC		26.9325521595
672PhosphorylationGTPPPDCTPQAQDSP
CCCCCCCCCCCCCCC		26.3023140645
729PhosphorylationFPVTGQDSSSDEEDE
CCCCCCCCCCCCCCC		24.6925338131
730PhosphorylationPVTGQDSSSDEEDED
CCCCCCCCCCCCCCC		50.5325338131
731PhosphorylationVTGQDSSSDEEDEDE
CCCCCCCCCCCCCCC		53.6625338131
751PhosphorylationSQSFLPASDSDSDII
CCCCCCCCCCCCCCC		35.3925293948
753PhosphorylationSFLPASDSDSDIIFD
CCCCCCCCCCCCCCC		36.2025293948
755PhosphorylationLPASDSDSDIIFDNE
CCCCCCCCCCCCCCC		34.3625293948
869PhosphorylationIGDFGLATDHLAFTA
ECCCCEECCEEEEEE		29.06-
898PhosphorylationSDPSGHLTGMVGTAL
CCCCCCCEECEEEEE		19.9822817900
903PhosphorylationHLTGMVGTALYVSPE
CCEECEEEEEEECHH		11.33-
957PhosphorylationLNQLRDPTSPKFPDD
ECCCCCCCCCCCCCC		63.0526745281
958PhosphorylationNQLRDPTSPKFPDDF
CCCCCCCCCCCCCCC		31.3326745281
1258AcetylationNSLCRLYKFIEQKGD
HHHHHHHHHHHHCCC		44.4522826441
1290PhosphorylationVAQLVKYSLKDLEDV
HHHHHHHHCCCHHHH		24.1924719451
1462AcetylationDKEGSHVKVKSFEKE
CCCCCEEEEEECHHH		38.2223576753
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of E2AK4_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
898TPhosphorylation

12176355
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of E2AK4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of E2AK4_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of E2AK4_MOUSE

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Related Literatures of Post-Translational Modification

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