DYN3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DYN3_RAT
• UniProt AC: Q08877
• Protein Name: Dynamin-3
• Gene Name: Dnm3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 869
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Microtubule-associated. Isoform-specific localization.; Isoform 2: Cytoplasmic vesicle .; Isoform 8: Cytoplasm. Golgi apparatus .
• Protein Description: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis..
• Protein Sequence: MGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRHEIEAETDRVTGMNKGISSVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIRDMIMQFITRENCLILAVTPANTDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAFKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVMQELINTVKKCTKRLANFPRLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKSTIGNQGTNLPPSRQIVIRKGWLTVSNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKGFMSSKHVFALFNTEQRNVYKDYRSLELACDSQEDVDSWKASLLRAGVYPDKSFTENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFINSELLAQLYSSEDQNTLMEESVEQAQRRDEMLRMYQALKEALAIIGDINTVTVSTPAPPPVDDSWLQHSRRSPPPSPTTQRRLTLSAPLPRPASSRGPAPAIPSPGPHSGAPPVPFRPGPLPPFPNSSDSYGAPPQVPSRPTRAPPSVPSRRPPPSPTRPTIIRPLESSLLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	GGQSAGKSSVLENFV CCCCCCCHHHHHHHC	25.43	25403869
46	Phosphorylation	GQSAGKSSVLENFVG CCCCCCHHHHHHHCC	33.92	25403869
61	Phosphorylation	RDFLPRGSGIVTRRP CCCCCCCCCCCCCCC	26.99	25403869
80	Phosphorylation	LVTSKAEYAEFLHCK HHHCHHHHHHHHCCC	19.11	-
191	Acetylation	SDALKLAKEVDPQGL CHHHHHHHHCCCCCC	69.57	-
231	Phosphorylation	LLPLRRGYVGVVNRS CCCCCCCCEEEECCC	7.69	-
257	Acetylation	AAMLAERKFFLSHPA HHHHHHHHHHHCCHH	31.79	22902405
299	Acetylation	TLPNFRNKLQGQLLS HHHHHHHHHHHHEEC	37.62	22902405
568	Acetylation	DDEEKEKKYMLPLDN CCHHHHHCEEEECCC	36.66	22902405
603	Phosphorylation	NTEQRNVYKDYRSLE EHHCCHHHHCHHHHH	11.16	-
604	Acetylation	TEQRNVYKDYRSLEL HHCCHHHHCHHHHHH	43.96	22902405
769	Phosphorylation	WLQHSRRSPPPSPTT HHHCCCCCCCCCCCC	40.42	14762214
773	Phosphorylation	SRRSPPPSPTTQRRL CCCCCCCCCCCCCEE	40.42	30411139
775	Phosphorylation	RSPPPSPTTQRRLTL CCCCCCCCCCCEEEE	39.64	27097102
776	Phosphorylation	SPPPSPTTQRRLTLS CCCCCCCCCCEEEEE	24.38	22108457
853	Phosphorylation	PSRRPPPSPTRPTII CCCCCCCCCCCCCCC	44.68	17376771

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DYN3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DYN3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DYN3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of DYN3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The in vivo phosphorylation sites of rat brain dynamin I.";
Graham M.E., Anggono V., Bache N., Larsen M.R., Craft G.E.,Robinson P.J.;
J. Biol. Chem. 282:14695-14707(2007).
Cited for: PROTEIN SEQUENCE OF 839-859 (ISOFORM 1/3/5/7/9/11), PHOSPHORYLATION ATSER-769; SER-773 AND SER-853, AND MASS SPECTROMETRY.
PubMed: 17376771