DYL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DYL2_MOUSE
• UniProt AC: Q9D0M5
• Protein Name: Dynein light chain 2, cytoplasmic
• Gene Name: Dynll2
• Organism: Mus musculus (Mouse).
• Sequence Length: 89
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity)..
• Protein Sequence: MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Malonylation	SDRKAVIKNADMSED CCHHHHHHCCCCCHH	39.21	26320211
14	Phosphorylation	VIKNADMSEDMQQDA HHHCCCCCHHHHHHH	30.87	26525534
24	S-nitrosocysteine	MQQDAVDCATQAMEK HHHHHHHHHHHHHHH	3.38	-
24	S-nitrosylation	MQQDAVDCATQAMEK HHHHHHHHHHHHHHH	3.38	21278135
36	Acetylation	MEKYNIEKDIAAYIK HHHCCCHHHHHHHHH	51.11	23954790
36	Ubiquitination	MEKYNIEKDIAAYIK HHHCCCHHHHHHHHH	51.11	27667366
36	Malonylation	MEKYNIEKDIAAYIK HHHCCCHHHHHHHHH	51.11	26073543
36	Succinylation	MEKYNIEKDIAAYIK HHHCCCHHHHHHHHH	51.11	23954790
44	Ubiquitination	DIAAYIKKEFDKKYN HHHHHHHHHHHCCCC	54.80	-
49	Ubiquitination	IKKEFDKKYNPTWHC HHHHHHCCCCCCCEE	52.70	-
56	S-nitrosocysteine	KYNPTWHCIVGRNFG CCCCCCEEEECCCCH	1.71	-
56	S-nitrosylation	KYNPTWHCIVGRNFG CCCCCCEEEECCCCH	1.71	21278135
64	Phosphorylation	IVGRNFGSYVTHETK EECCCCHHHCCCCHH	16.58	25367039
65	Phosphorylation	VGRNFGSYVTHETKH ECCCCHHHCCCCHHH	15.11	25367039
67	Phosphorylation	RNFGSYVTHETKHFI CCCHHHCCCCHHHHH	13.03	25367039
88	Phosphorylation	VAILLFKSG------ HHHHHHHCC------	42.26	15504720

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DYL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DYL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DYL2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DYL2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.