DYH7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DYH7_HUMAN
• UniProt AC: Q8WXX0
• Protein Name: Dynein heavy chain 7, axonemal
• Gene Name: DNAH7
• Organism: Homo sapiens (Human).
• Sequence Length: 4024
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme .
• Protein Description: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity)..
• Protein Sequence: MSSEQDKSASKEKSKKPVRFLPQLSMEKLASKEKFKAPARALPQLSMVSTKPHWQQAAPSFHLSVKQDDESPEPFSVKNEQSHAEYMERFGKKGKLPHQVDDSYVGPSTSKSKGKSPHKERENFRSTLVNVIMQQDADLDSAVPDGSTIPKPTASAIEKDILRYYYYIHHGIDTDHVAPMEDSWLEHVLDLVPQHLKVFTDSIVTLSDEMREDYLLSVRKSIVDFVLKDPREKGDDKKTDELPAHRAEMEILPKPWRKSFLAASSYIRDHLNAMNPTMLAVLDLWHTNFKKLRLVDIKEFHNCQDALELSSFQNIIMRHMDSAKETLLKMWFPEVQNIYYQGNKKKQLPTGDSSAKLESFFNCAAALMTLQLQDLTLVSMQDFTDLIAQPPDSVRAFEHPGFIMRLILDNDTIKFEPELSDYIDIFLNVYDVMIKAVSFVPRVETKLYSKWESKSKPTTLKPIILNEIVDAHKEKIKEVIMKESVAPTEHLRLYDKYDFLITRKAERDVDNFLAENHSYEKIIDEICKYQKLIEEIQYTSIKTIRLGMFEMHCEELIRALVKRADIICGKLLAKMFRDHQEVNTRLCDEFERIAEKALSTPPNTAELMEMKAYIQKVEVTDMIELEQRLVDSKNCLAFLIEYVNFSPADMRLNNSVFQWYGRMGEIFEEHRKIIKEKIEQYQEGLKLRCERFVEELESYAKQSEEFYSFGDLQDVQRYLKKAQILNGKLDLAADKIEQFNAEEEAFGWLPSVYPQRKKIQDGLNPYLRLYETAVEFSSNYRAWTEGPYHKVNPDQVEADIGNYWRGLYKLEKTFHDSPYALAMTKKVRSKVEDFKQHIPLIQVICNPGLRPRHWEAMSAIVGYPLQPSDDSTVSSFLDMNLEPYIDRFEGISEAASKEYSLEKAMEKMITEWDAVEFVIHSYRETGTFILASVDEIQMLLDDHIIKTQTMRGSPFIKPYEKQMREWEGKLLLLQEILDEWLKVQATWLYLEPIFSSPDIMSQMPEEGRRFTAVDKTWRDIMRSVMQDKHVLTVVTIDRMLERLKKSNELLELILKGLNEYLEKKRLFFPRFFFLSNDELLEILSETKDPTRVQPHLKKCFEGIAKVEFTETLDITHMKSSEGEVVELIEIISTAKARGQVEKWLVELERVMINSIHKVTGDATFAYTKYERINWVRDWPGQTVLCVSQIFWTKEVQTAIPMGIKALEQYLKTCNRQIDDIVTLVRGKLSMQNRVTLGALVVLDVHARDVLSSLVKKNISDDSDFEWLSQLRYYWQENHLETKMINAGLRYGYEYLGNSPRLVITPLTDRCYRTLFGALHLHLGGAPEGPAGTGKTETTKDLAKAVAKQCVVFNCSDGLDYLALGKFFKGLLSCGAWACFDEFNRIDLEVLSVVAQQILTIQRGINAGADILMFEGTELKLDPTCAVFITMNPGYAGRSELPDNLKALFRTVAMMVPDYAMIAEIVLYSCGFVTARPLSVKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPNENEEILLLRSIIDVNLPKFLSHDLPLFEGITSDLFPGVKLPKPDYNDLLAAIKDNCASMNLQMTAFFSEKILQVYEMMIVRHGFMIVGEPFGGKTSAYRVLAGALNDICEKGLMEENKVQITVLNPKSVTMGQLYGQFDSVSHEWSDGVLAVSFRAFASSVTPDRKWLIFDGPVDAVWIENMNTVLDDNKKLCLMSGEIIQMSPQMNLIFEPMDLEVASPATVSRCGMIYMEPHMLGWRPLMLSWVNLLPASVSVIQKEFIMGLFDRMVPVSVEFIRKHTKELSPTSDTNLVRSLMNLIDCFMDDFADEVKLKERNDRETYSLLEGIFLFSLIWSVGASCTDDDRLKFNKILRELMESPISDRTRNTFKLQSGTEQTSSKALTVPFPEKGTIYDYQFVTEGIGKWEPWIKKLKEAPPIPKDVMFNEIIVPTLDTIRYSALMELLTTHQKPSIFVGPTGTGKSVYITNFLLNQLNKEIYKPLLINFSAQTTAAQTQNIVMSKLDKRRKGVFGPPLGKRMVVFVDDVNMPAREVYGAQPPIELLRQWLDHWNWYDLKDCSMIKLVDIQIMCAMGPPGGGRNPVTPRYMRHFNIITINEFSDKSMYTIFSRILTWHLEICYKFPDEFLDLTTQIVNGTMTLYKEAMKNLLPTPAKSHYLFNLRDFSRVIQGVCLSRPETTETTEVIKRLWVHEVLRVYYDRLLDNTDRSWLINYIQEILRNYMYEDFHELFQRLDFDNDGMVEADDLRSLMFCDFHDPKREDTNYREIADVDNLRMIVEIHLEEYNNISKKPMNLVLFRFAIEHISRISRILKQPRSHALLVGVGGSGRQSVTRLAAHMADYSVFQVEISKGYDTTEWHEDLKVILRKCAEGEMQGVFLFTDTQIKEESFLEDVSNLLNAGEIPNLFALDEKQEICDKMRQLDRQRDKTKQTDGSPIALFNMFIDHCRSQLHVVLAMSPIGDAFRNRLRKFPALVNCCTIDWFQSWPEDALQAVASRFLEEIEMSEEIRDGCIDMCKSFHTSTIDLSKSFFVELQRYNYVTPTSYLELISTFKLLLEKKRSEVMKMKKRYEVGLEKLDSASSQVATMQMELEALHPQLKVASKEVDEMMIMIEKESVEVAKTEKIVKADETIANEQAMASKAIKDECDADLAGALPILESALAALDTLTAQDITVVKSMKSPPAGVKLVMEAICILKGIKADKIPDPTGSGKKIEDFWGPAKRLLGDMRFLQSLHEYDKDNIPPAYMNIIRKNYIPNPDFVPEKIRNASTAAEGLCKWVIAMDSYDKVAKIVAPKKIKLAAAEGELKIAMDGLRKKQAALKEVQDKLARLQDTLELNKQKKADLENQVDLCSKKLERAEQLIGGLGGEKTRWSHTALELGQLYINLTGDILISSGVVAYLGAFTSTYRQNQTKEWTTLCKGRDIPCSDDCSLMGTLGEAVTIRTWNIAGLPSDSFSIDNGIIIMNARRWPLMIDPQSQANKWIKNMEKANSLYVIKLSEPDYVRTLENCIQFGTPVLLENVGEELDPILEPLLLKQTFKQGGSTCIRLGDSTIEYAPDFRFYITTKLRNPHYLPETSVKVTLLNFMITPEGMQDQLLGIVVAQERPDLEEEKQALILQGAENKRQLKEIEDKILEVLSSSEGNILEDETAIKILSSSKALANEISQKQEVAEETEKKIDTTRMGYRPIAIHSSILFFSLADLANIEPMYQYSLTWFINLFILSIENSEKSEILAKRLQILKDHFTYSLYVNVCRSLFEKDKLLFSFCLTINLLLHERAINKAEWRFLLTGGIGLDNPYANLCTWLPQKSWDEICRLDDLPAFKTIRREFMRLKDGWKKVYDSLEPHHEVFPEEWEDKANEFQRMLIIRCLRPDKVIPMLQEFIINRLGRAFIEPPPFDLAKAFGDSNCCAPLIFVLSPGADPMAALLKFADDQGYGGSKLSSLSLGQGQGPIAMKMLEKAVKEGTWVVLQNCHLATSWMPTLEKVCEELSPESTHPDFRMWLTSYPSPNFPVSVLQNGVKMTNEAPKGLRANIIRSYLMDPISDPEFFGSCKKPEEFKKLLYGLCFFHALVQERRKFGPLGWNIPYEFNETDLRISVQQLHMFLNQYEELPYEALRYMTGECNYGGRVTDDWDRRTLRSILNKFFNPELVENSDYKFDSSGIYFVPPSGDHKSYIEYTKTLPLTPAPEIFGMNANADITKDQSETQLLFDNILLTQSRSAGAGAKSSDEVVNEVASDILGKLPNNFDIEAAMRRYPTTYTQSMNTVLVQEMGRFNKLLKTIRDSCVNIQKAIKGLAVMSTDLEEVVSSILNVKIPEMWMGKSYPSLKPLGSYVNDFLARLKFLQQWYEVGPPPVFWLSGFFFTQAFLTGAQQNYARKYTIPIDLLGFDYEVMEDKEYKHPPEDGVFIHGLFLDGASWNRKIKKLAESHPKILYDTVPVMWLKPCKRADIPKRPSYVAPLYKTSERRGVLSTTGHSTNFVIAMTLPSDQPKEHWIGRGVALLCQLNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSEQDKSA ------CCHHHHHHH	54.62	-
8	Phosphorylation	MSSEQDKSASKEKSK CCHHHHHHHCHHHHC	46.17	-
25	Phosphorylation	VRFLPQLSMEKLASK CCHHHHCCHHHHHCC	21.46	25693802
71	Phosphorylation	SVKQDDESPEPFSVK EEECCCCCCCCCCCC	41.37	30622161
95	Acetylation	ERFGKKGKLPHQVDD HHHHCCCCCCCCCCC	68.66	20167786
103	Phosphorylation	LPHQVDDSYVGPSTS CCCCCCCCCCCCCCC	19.77	26055452
112	Phosphorylation	VGPSTSKSKGKSPHK CCCCCCCCCCCCCCH	46.54	27251275
113	Acetylation	GPSTSKSKGKSPHKE CCCCCCCCCCCCCHH	74.27	20167786
116	Phosphorylation	TSKSKGKSPHKEREN CCCCCCCCCCHHHHH	40.69	27251275
200	Phosphorylation	PQHLKVFTDSIVTLS HHHHHHHHCCEEECC	31.65	-
205	Phosphorylation	VFTDSIVTLSDEMRE HHHCCEEECCHHHHH	20.90	-
207	Phosphorylation	TDSIVTLSDEMREDY HCCEEECCHHHHHHH	23.35	-
214	Phosphorylation	SDEMREDYLLSVRKS CHHHHHHHHHHHHHH	12.56	22817900
217	Phosphorylation	MREDYLLSVRKSIVD HHHHHHHHHHHHHHH	19.79	-
221	Phosphorylation	YLLSVRKSIVDFVLK HHHHHHHHHHHHHHC	19.78	-
412	Phosphorylation	RLILDNDTIKFEPEL EEEECCCCEECCHHH	32.11	26546556
414	Methylation	ILDNDTIKFEPELSD EECCCCEECCHHHHH	45.85	-
414	"N6,N6-dimethyllysine"	ILDNDTIKFEPELSD EECCCCEECCHHHHH	45.85	-
438	Phosphorylation	DVMIKAVSFVPRVET HHHHHHHHCCCCCCC	25.94	23403867
484	Phosphorylation	KEVIMKESVAPTEHL HHHHHHCCCCCCHHH	20.33	25278378
488	Phosphorylation	MKESVAPTEHLRLYD HHCCCCCCHHHHHHH	26.71	25278378
502	Phosphorylation	DKYDFLITRKAERDV HHCCEEEEECCHHCH	28.41	24719451
538	Phosphorylation	KLIEEIQYTSIKTIR HHHHHHHCCCCCEEE	14.23	26074081
539	Phosphorylation	LIEEIQYTSIKTIRL HHHHHHCCCCCEEEE	13.96	26074081
540	Phosphorylation	IEEIQYTSIKTIRLG HHHHHCCCCCEEEEC	19.70	26074081
570	Methylation	RADIICGKLLAKMFR HHHHHHHHHHHHHHH	35.60	-
570	Acetylation	RADIICGKLLAKMFR HHHHHHHHHHHHHHH	35.60	7681855
570	Trimethylation	RADIICGKLLAKMFR HHHHHHHHHHHHHHH	35.60	-
803	Phosphorylation	VEADIGNYWRGLYKL CHHHHHHHHHHHHHH	7.41	-
813	Phosphorylation	GLYKLEKTFHDSPYA HHHHHHHHHCCCHHH	19.48	-
900	Phosphorylation	EAASKEYSLEKAMEK HHHHHHCCHHHHHHH	31.01	-
953	Phosphorylation	KTQTMRGSPFIKPYE HCCCCCCCCCCCCHH	13.28	24719451
959	Phosphorylation	GSPFIKPYEKQMREW CCCCCCCHHHHHHHH	30.65	24719451
1066	Ubiquitination	EYLEKKRLFFPRFFF HHHHHHCCCCCEEEE	7.72	22505724
1111	Ubiquitination	AKVEFTETLDITHMK EECEEEEEEECEECC	27.03	22505724
1117	Ubiquitination	ETLDITHMKSSEGEV EEEECEECCCCCCCE	3.18	22505724
1142	Acetylation	KARGQVEKWLVELER HHCCCHHHHHHHHHH	47.15	21466224
1154	Phosphorylation	LERVMINSIHKVTGD HHHHHHHHHHHHHCC	18.36	-
1157	Ubiquitination	VMINSIHKVTGDATF HHHHHHHHHHCCCEE	39.56	22505724
1197	Phosphorylation	FWTKEVQTAIPMGIK ECCHHHHHHCHHHHH	31.56	20068231
1251	Phosphorylation	VHARDVLSSLVKKNI HHHHHHHHHHHHCCC	22.83	-
1252	Phosphorylation	HARDVLSSLVKKNIS HHHHHHHHHHHCCCC	32.78	-
1485	Phosphorylation	SVKIVATYRLCSEQL CEEEEEEEECCHHHH	7.58	18083107
1498	Phosphorylation	QLSSQHHYDYGMRAV HHHCCCCHHHHHHHH	14.56	22817900
1531	Phosphorylation	EEILLLRSIIDVNLP CCEEEEEEHHHCCCH	24.70	22210691
1542	Phosphorylation	VNLPKFLSHDLPLFE CCCHHHHCCCCCCCC	20.35	22210691
1552	Phosphorylation	LPLFEGITSDLFPGV CCCCCCCCCCCCCCC	27.35	22210691
1661	Phosphorylation	QLYGQFDSVSHEWSD HHHCCEECCCEECCC	27.15	22210691
1663	Phosphorylation	YGQFDSVSHEWSDGV HCCEECCCEECCCCE	21.46	22210691
1683	Phosphorylation	RAFASSVTPDRKWLI HHHHCCCCCCCCEEE	22.78	26091039
1852	Phosphorylation	LEGIFLFSLIWSVGA HHHHHHHHHHHHCCC	22.54	-
1862	Phosphorylation	WSVGASCTDDDRLKF HHCCCCCCCCHHHHH	39.71	-
1987	Phosphorylation	TGKSVYITNFLLNQL CCCHHHHHHHHHHHH	11.39	25627689
2160	Phosphorylation	VNGTMTLYKEAMKNL HCCHHHHHHHHHHHC	9.52	22817900
2170	Phosphorylation	AMKNLLPTPAKSHYL HHHHCCCCCCCCCEE	35.53	20068231
2184	Phosphorylation	LFNLRDFSRVIQGVC EECHHHHHHHHHHHH	29.90	-
2335	Phosphorylation	RILKQPRSHALLVGV HHHCCCCCCEEEEEC	21.57	29083192
2345	Phosphorylation	LLVGVGGSGRQSVTR EEEECCCCCHHHHHH	25.52	29083192
2349	Phosphorylation	VGGSGRQSVTRLAAH CCCCCHHHHHHHHHH	24.89	29083192
2351	Phosphorylation	GSGRQSVTRLAAHMA CCCHHHHHHHHHHHC	25.80	29083192
2561	Phosphorylation	RYNYVTPTSYLELIS CCCCCCCHHHHHHHH	22.19	-
2642	Methylation	VEVAKTEKIVKADET HHHHHHHHHCCCCHH	59.01	-
2642	Trimethylation	VEVAKTEKIVKADET HHHHHHHHHCCCCHH	59.01	-
2787	Phosphorylation	PEKIRNASTAAEGLC CHHHHCCHHHHHHHH	23.33	26471730
2788	Phosphorylation	EKIRNASTAAEGLCK HHHHCCHHHHHHHHH	27.72	28464451
2802	Phosphorylation	KWVIAMDSYDKVAKI HHHHHCCCHHHHHHH	23.34	28464451
2816	Ubiquitination	IVAPKKIKLAAAEGE HHCCCCHHHHHHCCC	40.74	-
2856	Acetylation	QDTLELNKQKKADLE HHHHHHHHHHHHHHH	75.91	7695459
2858	Acetylation	TLELNKQKKADLENQ HHHHHHHHHHHHHHH	52.09	7695469
2888	Phosphorylation	GGLGGEKTRWSHTAL CCCCCCCCCCCCHHH	32.82	-
2934	Phosphorylation	QNQTKEWTTLCKGRD CCCCCCCEEEECCCC	15.81	-
2935	Phosphorylation	NQTKEWTTLCKGRDI CCCCCCEEEECCCCC	31.09	25072903
3009	Phosphorylation	KNMEKANSLYVIKLS HCHHHHCCEEEEECC	26.41	25106551
3011	Phosphorylation	MEKANSLYVIKLSEP HHHHCCEEEEECCCC	10.43	25106551
3175	Phosphorylation	AIKILSSSKALANEI HHHHHHCCHHHHHHH	20.69	19413330
3342	Phosphorylation	DDLPAFKTIRREFMR CCCCHHHHHHHHHHC	17.17	28464451
3540	Phosphorylation	LQNGVKMTNEAPKGL HHCCEECCCCCCCCH	24.96	20068231
3657	Phosphorylation	WDRRTLRSILNKFFN CCHHHHHHHHHHHCC	34.24	24719451
3718	Acetylation	NANADITKDQSETQL CCCCCCCCCHHHHHH	54.85	20167786
3733	Phosphorylation	LFDNILLTQSRSAGA HHCCEEECCCCCCCC	22.51	29978859
3735	Phosphorylation	DNILLTQSRSAGAGA CCEEECCCCCCCCCC	23.98	29978859
3773	Phosphorylation	IEAAMRRYPTTYTQS HHHHHHHCCCCCCHH	8.45	22817900
3776	Phosphorylation	AMRRYPTTYTQSMNT HHHHCCCCCCHHHHH	21.77	-
3780	Phosphorylation	YPTTYTQSMNTVLVQ CCCCCCHHHHHHHHH	13.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DYH7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DYH7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DYH7_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DYH7_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.