DYH3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DYH3_HUMAN
• UniProt AC: Q8TD57
• Protein Name: Dynein heavy chain 3, axonemal
• Gene Name: DNAH3
• Organism: Homo sapiens (Human).
• Sequence Length: 4116
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme .
• Protein Description: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)..
• Protein Sequence: MGATGRLELTLAAPPHPGPAFQRSKARETQGEEEGSEMQIAKSDSIHHMSHSQGQPELPPLPASANEEPSGLYQTVMSHSFYPPLMQRTSWTLAAPFKEQHHHRGPSDSIANNYSLMAQDLKLKDLLKVYQPATISVPRDRTGQGLPSSGNRSSSEPMRKKTKFSSRNKEDSTRIKLAFKTSIFSPMKKEVKTSLTFPGSRPMSPEQQLDVMLQQEMEMESKEKKPSESDLERYYYYLTNGIRKDMIAPEEGEVMVRISKLISNTLLTSPFLEPLMVVLVQEKENDYYCSLMKSIVDYILMDPMERKRLFIESIPRLFPQRVIRAPVPWHSVYRSAKKWNEEHLHTVNPMMLRLKELWFAEFRDLRFVRTAEILAGKLPLQPQEFWDVIQKHCLEAHQTLLNKWIPTCAQLFTSRKEHWIHFAPKSNYDSSRNIEEYFASVASFMSLQLRELVIKSLEDLVSLFMIHKDGNDFKEPYQEMKFFIPQLIMIKLEVSEPIIVFNPSFDGCWELIRDSFLEIIKNSNGIPKLKYIPLKFSFTAAAADRQCVKAAEPGEPSMHAAATAMAELKGYNLLLGTVNAEEKLVSDFLIQTFKVFQKNQVGPCKYLNVYKKYVDLLDNTAEQNIAAFLKENHDIDDFVTKINAIKKRRNEIASMNITVPLAMFCLDATALNHDLCERAQNLKDHLIQFQVDVNRDTNTSICNQYSHIADKVSEVPANTKELVSLIEFLKKSSAVTVFKLRRQLRDASERLEFLMDYADLPYQIEDIFDNSRNLLLHKRDQAEMDLIKRCSEFELRLEGYHRELESFRKREVMTTEEMKHNVEKLNELSKNLNRAFAEFELINKEEELLEKEKSTYPLLQAMLKNKVPYEQLWSTAYEFSIKSEEWMNGPLFLLNAEQIAEEIGNMWRTTYKLIKTLSDVPAPRRLAENVKIKIDKFKQYIPILSISCNPGMKDRHWQQISEIVGYEIKPTETTCLSNMLEFGFGKFVEKLEPIGAAASKEYSLEKNLDRMKLDWVNVTFSFVKYRDTDTNILCAIDDIQMLLDDHVIKTQTMCGSPFIKPIEAECRKWEEKLIRIQDNLDAWLKCQATWLYLEPIFSSEDIIAQMPEEGRKFGIVDSYWKSLMSQAVKDNRILVAADQPRMAEKLQEANFLLEDIQKGLNDYLEKKRLFFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDNLEIVGMISSEKETVPFIQKIYPANAKGMVEKWLQQVEQMMLASMREVIGLGIEAYVKVPRNHWVLQWPGQVVICVSSIFWTQEVSQALAENTLLDFLKKSNDQIAQIVQLVRGKLSSGARLTLGALTVIDVHARDVVAKLSEDRVSDLNDFQWISQLRYYWVAKDVQVQIITTEALYGYEYLGNSPRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACFDEFNRIEVEVLSVVAQQILSIQQAIIRKLKTFIFEGTELSLNPTCAVFITMNPGYAGRAELPDNLKALFRTVAMMVPDYALIGEISLYSMGFLDSRSLAQKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEENESVLLLRALLDVNLAKFLAQDVPLFQGIISDLFPGVVLPKPDYEVFLKVLNDNIKKMKLQPVPWFIGKIIQIYEMMLVRHGYMIVGDPMGGKTSAYKVLAAALGDLHAANQMEEFAVEYKIINPKAITMGQLYGCFDQVSHEWMDGVLANAFREQASSLSDDRKWIIFDGPVDAIWIENMNTVLDDNKKLCLMSGEIIQMNSKMSLIFEPADLEQASPATVSRCGMIYMEPHQLGWKPLKDSYMDTLPSSLTKEHKELVNDMFMWLVQPCLEFGRLHCKFVVQTSPIHLAFSMMRLYSSLLDEIRAVEEEEMELGEGLSSQQIFLWLQGLFLFSLVWTVAGTINADSRKKFDVFFRNLIMGMDDNHPRPKSVKLTKNNIFPERGSIYDFYFIKQASGHWETWTQYITKEEEKVPAGAKVSELIIPTMETARQSFFLKTYLDHEIPMLFVGPTGTGKSAITNNFLLHLPKNTYLPNCINFSARTSANQTQDIIMSKLDRRRKGLFGPPIGKKAVVFVDDLNMPAKEVYGAQPPIELLRQWIDHGYWFDKKDTTRLDIVDMLLVTAMGPPGGGRNDITGRFTRHLNIISINAFEDDILTKIFSSIVDWHFGKGFDVMFLRYGKMLVQATKTIYRDAVENFLPTPSKSHYVFNLRDFSRVIQGVLLCPHTHLQDVEKCIRLWIHEVYRVFYDRLIDKEDRQVFFNMVKETTSNCFKQTIEKVLIHLSPTGKIVDDNIRSLFFGDYFKPESDQKIYDEITDLKQLTVVMEHYLEEFNNISKAPMSLVMFRFAIEHISRICRVLKQDKGHLLLVGIGGSGRQSAAKLSTFMNAYELYQIEITKNYAGNDWREDLKKIILQVGVATKSTVFLFADNQIKDESFVEDINMLLNTGDVPNIFPADEKADIVEKMQTAARTQGEKVEVTPLSMYNFFIERVINKISFSLAMSPIGDAFRNRLRMFPSLINCCTIDWFQSWPTDALELVANKFLEDVELDDNIRVEVVSMCKYFQESVKKLSLDYYNKLRRHNYVTPTSYLELILTFKTLLNSKRQEVAMMRNRYLTGLQKLDFAASQVAVMQRELTALQPQLILTSEETAKMMVKIEAETREADGKKLLVQADEKEANVAAAIAQGIKNECEGDLAEAMPALEAALAALDTLNPADISLVKSMQNPPGPVKLVMESICIMKGMKPERKPDPSGSGKMIEDYWGVSKKILGDLKFLESLKTYDKDNIPPLTMKRIRERFINHPEFQPAVIKNVSSACEGLCKWVRAMEVYDRVAKVVAPKRERLREAEGKLAAQMQKLNQKRAELKLVVDRLQALNDDFEEMNTKKKDLEENIEICSQKLVRAEKLISGLGGEKDRWTEAARQLGIRYTNLTGDVLLSSGTVAYLGAFTVDYRVQCQNQWLAECKDKVIPGFSDFSLSHTLGDPIKIRAWQIAGLPVDSFSIDNGIIVSNSRRWALMIDPHGQANKWIKNMEKANKLAVIKFSDSNYMRMLENALQLGTPVLIENIGEELDASIEPILLKATFKQQGVEYMRLGENIIEYSRDFKLYITTRLRNPHYLPEVAVKVCLLNFMITPLGLQDQLLGIVAAKEKPELEEKKNQLIVESAKNKKHLKEIEDKILEVLSMSKGNILEDETAIKVLSSSKVLSEEISEKQKVASMTETQIDETRMGYKPVAVHSATIFFCISDLANIEPMYQYSLTWFINLYMHSLTHSTKSEELNLRIKYIIDHFTLSIYNNVCRSLFEKDKLLFSLLLTIGIMKQKKEITEEVWYFLLTGGIALDNPYPNPAPQWLSEKAWAEIVRASALPKLHGLMEHLEQNLGEWKLIYDSAWPHEEQLPGSWKFSQGLEKMVILRCLRPDKMVPAVREFIAEHMGKLYIEAPTFDLQGSYNDSSCCAPLIFVLSPSADPMAGLLKFADDLGMGGTRTQTISLGQGQGPIAAKMINNAIKDGTWVVLQNCHLAASWMPTLEKICEEVIVPESTNARFRLWLTSYPSEKFPVSILQNGIKMTNEPPKGLRANLLRSYLNDPISDPVFFQSCAKAVMWQKMLFGLCFFHAVVQERRNFGPLGWNIPYEFNESDLRISMWQIQMFLNDYKEVPFDALTYLTGECNYGGRVTDDKDRRLLLSLLSMFYCKEIEEDYYSLAPGDTYYIPPHGSYQSYIDYLRNLPITAHPEVFGLHENADITKDNQETNQLFEGVLLTLPRQSGGSGKSPQEVVEELAQDILSKLPRDFDLEEVMKLYPVVYEESMNTVLRQELIRFNRLTKVVRRSLINLGRAIKGQVLMSSELEEVFNSMLVGKVPAMWAAKSYPSLKPLGGYVADLLARLTFFQEWIDKGPPVVFWISGFYFTQSFLTGVSQNYARKYTIPIDHIGFEFEVTPQETVMENNPEDGAYIKGLFLEGARWDRKTMQIGESLPKILYDPLPIIWLKPGESAMFLHQDIYVCPVYKTSARRGTLSTTGHSTNYVLSIELPTDMPQKHWINRGVASLCQLDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	MQIAKSDSIHHMSHS EEEEECCCCCCCCCC	30.80	29759185
75	Phosphorylation	EPSGLYQTVMSHSFY CCCCHHHHHHHCCCC	12.48	24719451
82	Phosphorylation	TVMSHSFYPPLMQRT HHHHCCCCCCHHCCC	13.62	24719451
98	Acetylation	WTLAAPFKEQHHHRG EEEECCCCCCCCCCC	56.24	24848959
136	Phosphorylation	VYQPATISVPRDRTG HHCCEEEECCCCCCC	23.01	24719451
142	Phosphorylation	ISVPRDRTGQGLPSS EECCCCCCCCCCCCC	37.84	-
160	Acetylation	SSSEPMRKKTKFSSR CCCCCCCHHCCCCCC	59.55	7823299
167	Dimethylation	KKTKFSSRNKEDSTR HHCCCCCCCHHHHHH	57.97	-
174	Dimethylation	RNKEDSTRIKLAFKT CCHHHHHHHHHEEEC	28.17	-
287	Phosphorylation	VQEKENDYYCSLMKS EECCCCHHHHHHHHH	20.25	23532336
294	Phosphorylation	YYCSLMKSIVDYILM HHHHHHHHHHHHHHC	17.55	23532336
313	Phosphorylation	RKRLFIESIPRLFPQ HHHHHHHCHHHHCCC	32.83	24719451
346	Phosphorylation	WNEEHLHTVNPMMLR CCHHHHHCCCHHHHH	28.48	28842319
437	Phosphorylation	SSRNIEEYFASVASF CCCCHHHHHHHHHHH	7.52	26074081
440	Phosphorylation	NIEEYFASVASFMSL CHHHHHHHHHHHHHH	14.33	26074081
443	Phosphorylation	EYFASVASFMSLQLR HHHHHHHHHHHHHHH	21.23	26074081
446	Phosphorylation	ASVASFMSLQLRELV HHHHHHHHHHHHHHH	15.79	26074081
456	Phosphorylation	LRELVIKSLEDLVSL HHHHHHHHHHHHHHH	26.35	26074081
523	Phosphorylation	FLEIIKNSNGIPKLK HHHHHHCCCCCCCCC	31.28	26552605
571	Phosphorylation	AMAELKGYNLLLGTV HHHHHCCCCEEECCC	10.89	-
577	Phosphorylation	GYNLLLGTVNAEEKL CCCEEECCCCHHHHH	15.57	-
620	Phosphorylation	YVDLLDNTAEQNIAA HHHHHCCCHHHHHHH	31.10	29083192
630	Acetylation	QNIAAFLKENHDIDD HHHHHHHHHCCCHHH	50.44	20167786
711	Acetylation	QYSHIADKVSEVPAN HHHHHHHHHHCCCCC	38.34	25038526
713	Phosphorylation	SHIADKVSEVPANTK HHHHHHHHCCCCCHH	38.32	-
719	Phosphorylation	VSEVPANTKELVSLI HHCCCCCHHHHHHHH	28.18	-
724	Phosphorylation	ANTKELVSLIEFLKK CCHHHHHHHHHHHHH	35.93	-
731	Acetylation	SLIEFLKKSSAVTVF HHHHHHHHCCCHHHH	52.36	19810257
736	Phosphorylation	LKKSSAVTVFKLRRQ HHHCCCHHHHHHHHH	21.68	24505115
739	Acetylation	SSAVTVFKLRRQLRD CCCHHHHHHHHHHCC	36.43	19810267
829	Phosphorylation	VEKLNELSKNLNRAF HHHHHHHHHHHHHHH	17.20	24961811
856	Phosphorylation	LEKEKSTYPLLQAML HHHHHCCHHHHHHHH	10.04	-
880	Phosphorylation	WSTAYEFSIKSEEWM HHHEEEEECCCHHHH	19.71	24719451
1314	Phosphorylation	LLDFLKKSNDQIAQI HHHHHHHCHHHHHHH	44.01	-
1412	Phosphorylation	TPLTDRCYRTLMGAL ECCCHHHHHHHHHHH	13.92	29083192
1414	Phosphorylation	LTDRCYRTLMGALKL CCHHHHHHHHHHHHC	8.46	29083192
1444	Methylation	ETTKDLAKALAKQCV CHHHHHHHHHHHCCE	51.75	-
1444	"N6,N6-dimethyllysine"	ETTKDLAKALAKQCV CHHHHHHHHHHHCCE	51.75	-
1586	Phosphorylation	AQKIVATYRLCSEQL HHHHHHHHHHHHHHH	7.58	22817900
1599	Phosphorylation	QLSSQHHYDYGMRAV HHHCCCCHHHHHHHH	14.56	22817900
1682	Acetylation	NDNIKKMKLQPVPWF HCCHHHCCCCCCCHH	53.50	7675443
1692	Acetylation	PVPWFIGKIIQIYEM CCCHHHHHHHHHHHH	31.64	7675451
1743	Phosphorylation	MEEFAVEYKIINPKA HHHHHHEEEECCHHH	10.82	-
1784	Phosphorylation	REQASSLSDDRKWII HHHHHCCCCCCCEEE	39.14	26033855
1923	Phosphorylation	SMMRLYSSLLDEIRA HHHHHHHHHHHHHHH	21.28	24275569
2118	Phosphorylation	QTQDIIMSKLDRRRK HHHHHHHHHHHHHCC	21.47	-
2255	Phosphorylation	VQATKTIYRDAVENF HHHHHHHHHHHHHHC	13.99	30576142
2291	Phosphorylation	GVLLCPHTHLQDVEK HEEECCCCCHHHHHH	14.93	25332170
2447	Phosphorylation	RQSAAKLSTFMNAYE HHHHHHHHHHHHHHH	20.92	25907765
2448	Phosphorylation	QSAAKLSTFMNAYEL HHHHHHHHHHHHHHH	37.02	25907765
2453	Phosphorylation	LSTFMNAYELYQIEI HHHHHHHHHHHEEEE	11.06	25907765
2456	Phosphorylation	FMNAYELYQIEITKN HHHHHHHHEEEECCC	8.77	25907765
2636	Phosphorylation	QESVKKLSLDYYNKL HHHHHHHCHHHHHHH	28.24	-
2639	Phosphorylation	VKKLSLDYYNKLRRH HHHHCHHHHHHHHHC	17.77	-
2640	Phosphorylation	KKLSLDYYNKLRRHN HHHCHHHHHHHHHCC	12.89	-
2783	Phosphorylation	TLNPADISLVKSMQN HCCHHHHHHHHHCCC	27.88	24719451
2796	Methylation	QNPPGPVKLVMESIC CCCCCCCHHHHEEHH	38.20	-
2817	Phosphorylation	PERKPDPSGSGKMIE CCCCCCCCCCCCCCH	53.63	23532336
2819	Phosphorylation	RKPDPSGSGKMIEDY CCCCCCCCCCCCHHH	39.31	23532336
2826	Phosphorylation	SGKMIEDYWGVSKKI CCCCCHHHHHCCHHH	7.41	-
2846	Phosphorylation	FLESLKTYDKDNIPP HHHHHCCCCCCCCCC	21.29	-
2921	Ubiquitination	KLAAQMQKLNQKRAE HHHHHHHHHHHHHHH	44.02	-
2972	Phosphorylation	VRAEKLISGLGGEKD HHHHHHHHCCCCCHH	38.10	24719451
2982	Phosphorylation	GGEKDRWTEAARQLG CCCHHHHHHHHHHHC	19.35	24719451
3100	Acetylation	KNMEKANKLAVIKFS HCHHHHCCEEEEEEC	42.56	59609
3146	Phosphorylation	EPILLKATFKQQGVE HHHHHHHHHHHCCCE	29.76	22210691
3228	Phosphorylation	KNQLIVESAKNKKHL HHHHHHHHHCCHHHH	33.38	-
3249	Phosphorylation	ILEVLSMSKGNILED HHHHHHCCCCCCCCC	33.75	24850871
3281	Phosphorylation	SEKQKVASMTETQID CHHHHHHHCCCCCCC	29.26	26270265
3283	Phosphorylation	KQKVASMTETQIDET HHHHHHCCCCCCCCC	33.13	26270265
3285	Phosphorylation	KVASMTETQIDETRM HHHHCCCCCCCCCCC	22.97	26270265
3290	Phosphorylation	TETQIDETRMGYKPV CCCCCCCCCCCCCCC	23.39	26270265
3528	Phosphorylation	LIFVLSPSADPMAGL EEEEECCCCCHHHHH	41.76	25332170
3696	Phosphorylation	PLGWNIPYEFNESDL CCCCCCCCCCCHHHH	29.38	-
3717	Phosphorylation	IQMFLNDYKEVPFDA HHHHHHCCCCCCCCH	14.15	-
3824	Phosphorylation	LFEGVLLTLPRQSGG HEEEEEEECCCCCCC	30.47	24719451
3835	O-linked_Glycosylation	QSGGSGKSPQEVVEE CCCCCCCCHHHHHHH	35.03	29351928
3864	Phosphorylation	LEEVMKLYPVVYEES HHHHHHHHHHHCHHH	6.61	22817900
3868	Phosphorylation	MKLYPVVYEESMNTV HHHHHHHCHHHHHHH	17.76	22817900
3893	Phosphorylation	LTKVVRRSLINLGRA HHHHHHHHHHHHHHH	24.04	27251275
3932	Phosphorylation	AMWAAKSYPSLKPLG HHHCCCCCCCCCCCC	8.99	-
3941	Phosphorylation	SLKPLGGYVADLLAR CCCCCCHHHHHHHHH	7.23	-
4031	Phosphorylation	GARWDRKTMQIGESL CCCCCHHHCCCCCCC	18.40	23403867
4037	Phosphorylation	KTMQIGESLPKILYD HHCCCCCCCCHHHCC	44.77	23403867
4078	Phosphorylation	KTSARRGTLSTTGHS CCCCCCCCCCCCCCC	18.74	22210691
4096	Phosphorylation	VLSIELPTDMPQKHW EEEEECCCCCCCCHH	58.51	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DYH3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DYH3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DYH3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DYH3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.