DYH2_HUMAN - dbPTM
DYH2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DYH2_HUMAN
UniProt AC Q9P225
Protein Name Dynein heavy chain 2, axonemal
Gene Name DNAH2
Organism Homo sapiens (Human).
Sequence Length 4427
Subcellular Localization Cytoplasm, cytoskeleton, cilium axoneme .
Protein Description Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)..
Protein Sequence MSSKAEKKQRLSGRGSSQASWSGRATRAAVATQEQGNAPAVSEPELQAELPKEEPEPRLEGPQAQSEESVEPEADVKPLFLSRAALTGLADAVWTQEHDAILEHFAQDPTESILTIFIDPCFGLKLELGMPVQTQNQLVYFIRQAPVPITWENFEATVQFGTVRGPYIPALLRLLGGVFAPQIFANTGWPESIRNHFASHLHKFLACLTDTRYKLEGHTVLYIPAEAMNMKPEMVIKDKELVQRLETSMIHWTRQIKEMLSAQETVETGENLGPLEEIEFWRNRCMDLSGISKQLVKKGVKHVESILHLAKSSYLAPFMKLAQQIQDGSRQAQSNLTFLSILKEPYQELAFMKPKDISSKLPKLISLIRIIWVNSPHYNTRERLTSLFRKVCDCQYHFARWEDGKQGPLPCFFGAQGPQITRNLLEIEDIFHKNLHTLRAVRGGILDVKNTCWHEDYNKFRAGIKDLEVMTQNLITSAFELVRDVPHGVLLLDTFHRLASREAIKRTYDKKAVDLYMLFNSELALVNRERNKKWPDLEPYVAQYSGKARWVHILRRRIDRVMTCLAGAHFLPRIGTGKESVHTYQQMVQAIDELVRKTFQEWTSSLDKDCIRRLDTPLLRISQEKAGMLDVNFDKSLLILFAEIDYWERLLFETPHYVVNVAERAEDLRILRENLLLVARDYNRIIAMLSPDEQALFKERIRLLDKKIHPGLKKLHWALKGASAFFITECRIHASKVQMIVNEFKASTLTIGWRAQEMSEKLLVRISGKRVYRDLEFEEDQREHRAAVQQKLMNLHQDVVTIMTNSYEVFKNDGPEIQQQWMLYMIRLDRMMEDALRLNVKWSLLELSKAINGDGKTSPNPLFQVLVILKNDLQGSVAQVEFSPTLQTLAGVVNDIGNHLFSTISVFCHLPDILTKRKLHREPIQTVVEQDEDIKKIQTQISSGMTNNASLLQNYLKTWDMYREIWEINKDSFIHRYQRLNPPVSSFVADIARYTEVANNVQKEETVTNIQFVLLDCSHLKFSLVQHCNEWQNKFATLLREMAAGRLLELHTYLKENAEKISRPPQTLEELGVSLQLVDALKHDLANVETQIPPIHEQFAILEKYEVPVEDSVLEMLDSLNGEWVVFQQTLLDSKQMLKKHKEKFKTGLIHSADDFKKKAHTLLEDFEFKGHFTSNVGYMSALDQITQVRAMLMAMREEENSLRANLGIFKIEQPPSKDLQNLEKELDALQQIWEIARDWEENWNEWKTGRFLILQTETMETTAHGLFRRLTKLAKEYKDRNWEIIETTRSKIEQFKRTMPLISDLRNPALRERHWDQVRDEIQREFDQESESFTLEQIVELGMDQHVEKIGEISASATKELAIEVALQNIAKTWDVTQLDIVPYKDKGHHRLRGTEEVFQALEDNQVALSTMKASRFVKAFEKDVDHWERCLSLILEVIEMILTVQRQWMYLENIFLGEDIRKQLPNESTLFDQVNSNWKAIMDRMNKDNNALRSTHHPGLLDTLIEMNTILEDIQKSLDMYLETKRHIFPRFYFLSNDDLLEILGQSRNPEAVQPHLKKCFDNIKLLRIQKVGGPSSKWEAVGMFSGDGEYIDFLHSVFLEGPVESWLGDVEQTMRVTLRDLLRNCHLALRKFLNKRDKWVKEWAGQVVITASQIQWTADVTKCLLTAKERADKKILKVMKKNQVSILNKYSEAIRGNLTKIMRLKIVALVTIEIHARDVLEKLYKSGLMDVNSFDWLSQLRFYWEKDLDDCVIRQTNTQFQYNYEYLGNSGRLVITPLTDRCYMTLTTALHLHRGGSPKGPAGTGKTETVKDLGKALGIYVIVVNCSEGLDYKSMGRMYSGLAQTGAWGCFDEFNRINIEVLSVVAHQILCILSALAAGLTHFHFDGFEINLVWSCGIFITMNPGYAGRTELPENLKSMFRPIAMVVPDSTLIAEIILFGEGFGNCKILAKKVYTLYSLAVQQLSRQDHYDFGLRALTSLLRYAGKKRRLQPDLTDEEVLLLSMRDMNIAKLTSVDAPLFNAIVQDLFPNIELPVIDYGKLRETVEQEIRDMGLQSTPFTLTKVFQLYETKNSRHSTMIVGCTGSGKTASWRILQASLSSLCRAGDPNFNIVREFPLNPKALSLGELYGEYDLSTNEWTDGILSSVMRTACADEKPDEKWILFDGPVDTLWIENMNSVMDDNKVLTLINGERIAMPEQVSLLFEVEDLAMASPATVSRCGMVYTDYADLGWKPYVQSWLEKRPKAEVEPLQRMFEKLINKMLAFKKDNCKELVPLPEYSGITSLCKLYSALATPENGVNPADGENYVTMVEMTFVFSMIWSVCASVDEEGRKRIDSYLREIEGSFPNKDTVYEYFVDPKIRSWTSFEDKLPKSWRYPPNAPFYKIMVPTVDTVRYNYLVSSLVANQNPILLVGPVGTGKTSIAQSVLQSLPSSQWSVLVVNMSAQTTSNNVQSIIESRVEKRTKGVYVPFGGKSMITFMDDLNMPAKDMFGSQPPLELIRLWIDYGFWYDRTKQTIKYIREMFLMAAMGPPGGGRTVISPRLRSRFNIINMTFPTKSQIIRIFGTMINQKLQDFEEEVKPIGNVVTEATLDMYNTVVQRFLPTPTKMHYLFNLRDISKVFQGMLRANKDFHDTKSSITRLWIHECFRVFSDRLVDAADTEAFMGIISDKLGSFFDLTFHHLCPSKRPPIFGDFLKEPKVYEDLTDLTVLKTVMETALNEYNLSPSVVPMQLVLFREAIEHITRIVRVIGQPRGNMLLVGIGGSGRQSLARLASSICDYTTFQIEVTKHYRKQEFRDDIKRLYRQAGVELKTTSFIFVDTQIADESFLEDINNILSSGEVPNLYKPDEFEEIQSHIIDQARVEQVPESSDSLFAYLIERVQNNLHIVLCLSPMGDPFRNWIRQYPALVNCTTINWFSEWPQEALLEVAEKCLIGVDLGTQENIHRKVAQIFVTMHWSVAQYSQKMLLELRRHNYVTPTKYLELLSGYKKLLGEKRQELLAQANKLRTGLFKIDETREKVQVMSLELEDAKKKVAEFQKQCEEYLVIIVQQKREADEQQKAVTANSEKIAVEEIKCQALADNAQKDLEEALPALEEAMRALESLNKKDIGEIKSYGRPPAQVEIVMQAVMILRGNEPTWAEAKRQLGEQNFIKSLINFDKDNISDKVLKKIGAYCAQPDFQPDIIGRVSLAAKSLCMWVRAMELYGRLYRVVEPKRIRMNAALAQLREKQAALAEAQEKLREVAEKLEMLKKQYDEKLAQKEELRKKSEEMELKLERAGMLVSGLAGEKARWEETVQGLEEDLGYLVGDCLLAAAFLSYMGPFLTNYRDEIVNQIWIGKIWELQVPCSPSFAIDNFLCNPTKVRDWNIQGLPSDAFSTENGIIVTRGNRWALMIDPQAQALKWIKNMEGGQGLKIIDLQMSDYLRILEHAIHFGYPVLLQNVQEYLDPTLNPMLNKSVARIGGRLLMRIGDKEVEYNTNFRFYITTKLSNPHYSPETSAKTTIVNFAVKEQGLEAQLLGIVVRKERPELEEQKDSLVINIAAGKRKLKELEDEILRLLNEATGSLLDDVQLVNTLHTSKITATEVTEQLETSETTEINTDLAREAYRPCAQRASILFFVLNDMGCIDPMYQFSLDAYISLFILSIDKSHRSNKLEDRIDYLNDYHTYAVYRYTCRTLFERHKLLFSFHMCAKILETSGKLNMDEYNFFLRGGVVLDREGQMDNPCSSWLADAYWDNITELDKLTNFHGLMNSFEQYPRDWHLWYTNAAPEKAMLPGEWENACNEMQRMLIVRSLRQDRVAFCVTSFIITNLGSRFIEPPVLNMKSVLEDSTPRSPLVFILSPGVDPTSALLQLAEHMGMAQRFHALSLGQGQAPIAARLLREGVTQGHWVFLANCHLSLSWMPNLDKLVEQLQVEDPHPSFRLWLSSIPHPDFPISILQVSIKMTTEPPKGLKANMTRLYQLMSEPQFSRCSKPAKYKKLLFSLCFFHSVLLERKKFLQLGWNIIYGFNDSDFEVSENLLSLYLDEYEETPWDALKYLIAGINYGGHVTDDWDRRLLTTYINDYFCDQSLSTPFHRLSALETYFIPKDGSLASYKEYISLLPGMDPPEAFGQHPNADVASQITEAQTLFDTLLSLQPQITPTRAGGQTREEKVLELAADVKQKIPEMIDYEGTQKLLALDPSPLNVVLLQEIQRYNTLMQTILFSLTDLEKGIQGLIVMSTSLEEIFNCIFDAHVPPLWGKAYPSQKPLAAWTRDLAMRVEQFELWASRARPPVIFWLSGFTFPTGFLTAVLQSSARQNNVSVDSLSWEFIVSTVDDSNLVYPPKDGVWVRGLYLEGAGWDRKNSCLVEAEPMQLVCLMPTIHFRPAESRKKSAKGMYSCPCYYYPNRAGSSDRASFVIGIDLRSGAMTPDHWIKRGTALLMSLDS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42PhosphorylationQGNAPAVSEPELQAE
CCCCCCCCCHHHHCC		49.9225693802
66PhosphorylationLEGPQAQSEESVEPE
CCCCCCCCCCCCCCC		46.4730622161
69PhosphorylationPQAQSEESVEPEADV
CCCCCCCCCCCCCCC		27.9430622161
284DimethylationEIEFWRNRCMDLSGI
HHHHHHHHCCCCCHH		14.46-
340PhosphorylationQSNLTFLSILKEPYQ
HHHCCHHHHHCCHHH		22.9924719451
346PhosphorylationLSILKEPYQELAFMK
HHHHCCHHHHHHCCC		18.73-
366PhosphorylationSKLPKLISLIRIIWV
HHHHHHHHHHHHEEE		28.34-
386PhosphorylationNTRERLTSLFRKVCD
CHHHHHHHHHHHHHC		30.0624719451
516PhosphorylationDKKAVDLYMLFNSEL
CCCHHHHHHHHCCHH		6.3130622161
521PhosphorylationDLYMLFNSELALVNR
HHHHHHCCHHHHHHH		27.0130622161
532AcetylationLVNRERNKKWPDLEP
HHHHHHCCCCCCCHH		63.5411921547
563PhosphorylationRRIDRVMTCLAGAHF
HHHHHHHHHHHHCCC		11.08-
580PhosphorylationRIGTGKESVHTYQQM
CCCCCCCCHHHHHHH		23.7619690332
616PhosphorylationDCIRRLDTPLLRISQ
HHHHHCCCCCHHCCH		22.0417924679
698MethylationPDEQALFKERIRLLD
HHHHHHHHHHHHHHH		47.1123644510
698UbiquitinationPDEQALFKERIRLLD
HHHHHHHHHHHHHHH		47.11-
728PhosphorylationGASAFFITECRIHAS
CCCEEEEEEECCCHH		24.7128258704
767PhosphorylationEKLLVRISGKRVYRD
HHHEEEECCCEEEEC		27.91-
876PhosphorylationLKNDLQGSVAQVEFS
EECCCCCCEEEEEEC		11.00-
926PhosphorylationLHREPIQTVVEQDED
CCCCCCCHHHHCHHH		27.52-
939PhosphorylationEDIKKIQTQISSGMT
HHHHHHHHHHHCCCC		31.2026074081
942PhosphorylationKKIQTQISSGMTNNA
HHHHHHHHCCCCCCH		15.8326074081
943PhosphorylationKIQTQISSGMTNNAS
HHHHHHHCCCCCCHH		33.9226074081
946PhosphorylationTQISSGMTNNASLLQ
HHHHCCCCCCHHHHH		28.9326074081
950PhosphorylationSGMTNNASLLQNYLK
CCCCCCHHHHHHHHH		31.5626074081
955PhosphorylationNASLLQNYLKTWDMY
CHHHHHHHHHHHHHH		9.1626074081
1292UbiquitinationIIETTRSKIEQFKRT
HHHHHHHHHHHHHHH		47.1533845483
1299PhosphorylationKIEQFKRTMPLISDL
HHHHHHHHCHHHHHC		24.5919413330
1304PhosphorylationKRTMPLISDLRNPAL
HHHCHHHHHCCCHHH		37.9724719451
1374PhosphorylationALQNIAKTWDVTQLD
HHHHHHHHCCCEEEE		20.20-
1411PhosphorylationEDNQVALSTMKASRF
HHCCHHHHHHHHHHH		19.4024719451
1412PhosphorylationDNQVALSTMKASRFV
HCCHHHHHHHHHHHH		24.4424719451
1416PhosphorylationALSTMKASRFVKAFE
HHHHHHHHHHHHHHH		22.2624719451
1445PhosphorylationEVIEMILTVQRQWMY
HHHHHHHHHHHHHHH		12.0324719451
1452PhosphorylationTVQRQWMYLENIFLG
HHHHHHHHHHHHHCC		14.1226270265
1535PhosphorylationRHIFPRFYFLSNDDL
HHHCCEEEEECCHHH		12.6124719451
1549PhosphorylationLLEILGQSRNPEAVQ
HHHHHCCCCCHHHHH		32.0224719451
1620PhosphorylationVEQTMRVTLRDLLRN
HHHHHHHHHHHHHHH		13.0024425749
1688PhosphorylationVMKKNQVSILNKYSE
HHHHCHHHHHHHHHH		16.1726074081
1693PhosphorylationQVSILNKYSEAIRGN
HHHHHHHHHHHHHCC		15.6326074081
1694PhosphorylationVSILNKYSEAIRGNL
HHHHHHHHHHHHCCC		23.3526074081
1702PhosphorylationEAIRGNLTKIMRLKI
HHHHCCCHHHHHCCE		23.6426074081
1765PhosphorylationQTNTQFQYNYEYLGN
CCCCEEEEEEEECCC		22.4725003641
1773PhosphorylationNYEYLGNSGRLVITP
EEEECCCCCEEEEEE		24.4025003641
1810PhosphorylationGPAGTGKTETVKDLG
CCCCCCCCCHHHHHH		37.9325278378
1812PhosphorylationAGTGKTETVKDLGKA
CCCCCCCHHHHHHHH		37.7825278378
1843PhosphorylationKSMGRMYSGLAQTGA
HHCHHHHHHHHHCCC		20.2822210691
1957PhosphorylationKILAKKVYTLYSLAV
HHHHHHHHHHHHHHH		10.4127642862
1960PhosphorylationAKKVYTLYSLAVQQL
HHHHHHHHHHHHHHH		8.2127642862
1968PhosphorylationSLAVQQLSRQDHYDF
HHHHHHHHCCCCHHH		24.4527642862
1982PhosphorylationFGLRALTSLLRYAGK
HHHHHHHHHHHHCCC		26.6824719451
2065PhosphorylationQSTPFTLTKVFQLYE
CCCCEEHHHHHHHHH		23.31-
2080PhosphorylationTKNSRHSTMIVGCTG
CCCCCCCEEEEECCC		12.56-
2086PhosphorylationSTMIVGCTGSGKTAS
CEEEEECCCCCHHHH		28.58-
2289AcetylationSGITSLCKLYSALAT
CCHHHHHHHHHHHCC		56.6119810377
2339PhosphorylationEGRKRIDSYLREIEG
HHHHHHHHHHHHHCC		24.5624850871
2353PhosphorylationGSFPNKDTVYEYFVD
CCCCCCCCCCEEECC		26.96-
2355PhosphorylationFPNKDTVYEYFVDPK
CCCCCCCCEEECCCC		13.65-
2400PhosphorylationVDTVRYNYLVSSLVA
CCCCCHHHHHHHHHC		10.27-
2520UbiquitinationDRTKQTIKYIREMFL
CCHHHHHHHHHHHHH		37.7032142685
2539PhosphorylationGPPGGGRTVISPRLR
CCCCCCCCCCCHHHH		26.01-
2542PhosphorylationGGGRTVISPRLRSRF
CCCCCCCCHHHHHCC		10.3024719451
2558PhosphorylationIINMTFPTKSQIIRI
EEECCCCCHHHHHHH		38.85-
2598PhosphorylationATLDMYNTVVQRFLP
HHHHHHHHHHHHHCC		12.4526074081
2606PhosphorylationVVQRFLPTPTKMHYL
HHHHHCCCCCCEEEE		45.8226074081
2714PhosphorylationTDLTVLKTVMETALN
CHHHHHHHHHHHHHH		22.41-
2955PhosphorylationKVAQIFVTMHWSVAQ
HHHHHHHHHCHHHHH		7.8029083192
2959PhosphorylationIFVTMHWSVAQYSQK
HHHHHCHHHHHHHHH		7.9029083192
2963PhosphorylationMHWSVAQYSQKMLLE
HCHHHHHHHHHHHHH		11.8829083192
2964PhosphorylationHWSVAQYSQKMLLEL
CHHHHHHHHHHHHHH		15.9629083192
2982PhosphorylationNYVTPTKYLELLSGY
CCCCHHHHHHHHHHH		14.1122210691
3064PhosphorylationDEQQKAVTANSEKIA
HHHHHHHHHCHHHEE		25.6123612710
3115PhosphorylationKDIGEIKSYGRPPAQ
CCHHHHHHCCCCHHH		38.1826330541
3116PhosphorylationDIGEIKSYGRPPAQV
CHHHHHHCCCCHHHH		16.5026330541
3155PhosphorylationGEQNFIKSLINFDKD
HHHHHHHHHHCCCCC		29.66-
3165PhosphorylationNFDKDNISDKVLKKI
CCCCCCCCHHHHHHH		37.32-
3206PhosphorylationWVRAMELYGRLYRVV
HHHHHHHHHHHHHHH		6.2118083107
3216UbiquitinationLYRVVEPKRIRMNAA
HHHHHCHHHHHHHHH		47.13-
3216AcetylationLYRVVEPKRIRMNAA
HHHHHCHHHHHHHHH		47.1330588229
3269PhosphorylationKEELRKKSEEMELKL
HHHHHHHHHHHHHHH		41.6530576142
3284PhosphorylationERAGMLVSGLAGEKA
HHHHHHHHHHHCCHH		24.9126074081
3296PhosphorylationEKARWEETVQGLEED
CHHHHHHHHHHHHHH		13.4526074081
3495PhosphorylationKLSNPHYSPETSAKT
CCCCCCCCCCCCCCE		17.15-
3534AcetylationRPELEEQKDSLVINI
CCCHHHHHCCEEEEH		53.1920167786
3549AcetylationAAGKRKLKELEDEIL
HHCHHHHHHHHHHHH		64.3920167786
3631PhosphorylationMGCIDPMYQFSLDAY
CCCCCHHHCCCHHHH		16.28-
3638PhosphorylationYQFSLDAYISLFILS
HCCCHHHHHHHHHHH		7.24-
3661PhosphorylationKLEDRIDYLNDYHTY
CHHHHHHHHHHHHHH		12.6718083107
3665PhosphorylationRIDYLNDYHTYAVYR
HHHHHHHHHHHHHHH		8.5918083107
3671PhosphorylationDYHTYAVYRYTCRTL
HHHHHHHHHHHHHHH		6.9618083107
3753PhosphorylationNFHGLMNSFEQYPRD
CCCHHHHHHHCCCCC		19.0529255136
3826PhosphorylationPPVLNMKSVLEDSTP
CCCCCHHHHHCCCCC		22.59-
3831PhosphorylationMKSVLEDSTPRSPLV
HHHHHCCCCCCCCEE		30.82-
3832PhosphorylationKSVLEDSTPRSPLVF
HHHHCCCCCCCCEEE		34.73-
3970PhosphorylationLMSEPQFSRCSKPAK
HHCCCCCCCCCCCHH		27.4228165663
4079PhosphorylationSTPFHRLSALETYFI
CCCCHHHHHCCEEEC		30.66-
4083PhosphorylationHRLSALETYFIPKDG
HHHHHCCEEECCCCC		25.28-
4141PhosphorylationLSLQPQITPTRAGGQ
HHCCCCCCCCCCCCC		17.2324719451
4424PhosphorylationRGTALLMSLDS----
HHHHHEECCCC----		29.0626270265
4427PhosphorylationALLMSLDS-------
HHEECCCC-------		47.6226270265
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DYH2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DYH2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DYH2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DYH2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DYH2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1299, AND MASSSPECTROMETRY.
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-616, AND MASSSPECTROMETRY.

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