DYH10_HUMAN - dbPTM
DYH10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DYH10_HUMAN
UniProt AC Q8IVF4
Protein Name Dynein heavy chain 10, axonemal
Gene Name DNAH10
Organism Homo sapiens (Human).
Sequence Length 4471
Subcellular Localization Cytoplasm, cytoskeleton, cilium axoneme .
Protein Description Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain..
Protein Sequence MVPEEVEVEIDEIPVLSEEGEEEEETYSQKVESVDKVRAKRVSLRTESLGQPLNREDEEMDKEISEKLPSKRTAKHIMEKMHLHMLCTPLPEEFLDQNVVFFLRNTKEAISEATDMKEAMEIMPETLEYGIINANVLHFLKNIICQVFLPALSFNQHRTSTTVGVTSGEVSNSSEHESDLPPMPGEAVEYHSIQLIRDEFLMNVQKFASNIQRTMQQLEGEIKLEMPIISVEGEVSDLAADPETVDILEQCVINWLNQISTAVEAQLKKTPQGKGPLAEIEFWRERNATLSALHEQTKLPIVRKVLDVIKESDSMLVANLQPVFTELFKFHTEASDNVRFLSTVERYFKNITHGSGFHVVLDTIPAMMSALRMVWIISRHYNKDERMIPLMERIAWEIAERVCRVVNLRTLFKENRASAQSKTLEARNTLRLWKKAYFDTRAKIEASGREDRWEFDRKRLFERTDYMATICQDLSDVLQILEEFYNIFGPELKAVTGDPKRIDDVLCRVDGLVTPMENLTFDPFSIKSSQFWKYVMDEFKIEVLIDIINKIFVQNLENPPLYKNHPPVAGAIYWERSLFFRIKHTILRFQEVQEILDSDRGQEVKQKYLEVGRTMKEYEDRKYEQWMEVTEQVLPALMKKSLLTKSSIATEEPSTLERGAVFAINFSPALREIINETKYLEQLGFTVPELARNVALQEDKFLRYTAGIQRMLDHYHMLIGTLNDAESVLLKDHSQELLRVFRSGYKRLNWNSLGIGDYITGCKQAIGKFESLVHQIHKNADDISSRLTLIEAINLFKYPAAKSEEELPGVKEFFEHIERERASDVDHMVRWYLAIGPLLTKVEGLVVHTNTGKAPKLASYYKYWEKKIYEVLTKLILKNLQSFNSLILGNVPLFHTETILTAPEIILHPNTNEIDKMCFHCVRNCVEITKHFVRWMNGSCIECPPQKGEEEEVVIINFYNDISLNPQIIEQAVMIPQNVHRILINLMKYLQKWKRYRPLWKLDKAIVMEKFAAKKPPCVAYDEKLQFYSKIAYEVMRHPLIKDEHCIRLQLRHLANTVQENAKSWVISLGKLLNESAKEELYNLHEEMEHLAKNLRKIPNTLEDLKFVLATIAEIRSKSLVMELRYRDVQERYRTMAMYNLFPPDAEKELVDKIESIWSNLFNDSVNVEHALGDIKRTFTELTRGEIMNYRVQIEEFAKRFYSEGPGSVGDDLDKGVELLGVYERELARHEKSRQELANAEKLFDLPITMYPELLKVQKEMSGLRMIYELYEGLKVAKEEWSQTLWINLNVQILQEGIEGFLRALRKLPRPVRGLSVTYYLEAKMKAFKDSIPLLLDLKNEALRDRHWKELMEKTSVFFEMTETFTLENMFAMELHKHTDVLNEIVTAAIKEVAIEKAVKEILDTWENMKFTVVKYCKGTQERGYILGSVDEIIQSLDDNTFNLQSISGSRFVGPFLQTVHKWEKTLSLIGEVIEIWMLVQRKWMYLESIFIGGDIRSQLPEEAKKFDNIDKVFKRIMGETLKDPVIKRCCEAPNRLSDLQNVSEGLEKCQKSLNDYLDSKRNAFPRFFFISDDELLSILGSSDPLCVQEHMIKMYDNIASLRFNDGDSGEKLVSAMISAEGEVMEFRKILRAEGRVEDWMTAVLNEMRRTNRLITKEAIFRYCEDRSRVDWMLLYQGMVVLAASQVWWTWEVEDVFHKAQKGEKQAMKNYGRKMHRQIDELVTRITMPLSKNDRKKYNTVLIIDVHARDIVDSFIRGSILEAREFDWESQLRFYWDREPDELNIRQCTGTFGYGYEYMGLNGRLVITPLTDRIYLTLTQALSMYLGGAPAGPAGTGKTETTKDLAKALGLLCVVTNCGEGMDYRAVGKIFSGLAQCGAWGCFDEFNRIDASVLSVISSQIQTIRNALIHQLTTFQFEGQEISLDSRMGIFITMNPGYAGRTELPESVKALFRPVVVIVPDLQQICEIMLFSEGFLEAKTLAKKMTVLYKLAREQLSKQYHYDFGLRALKSVLVMAGELKRGSSDLREDVVLMRALRDMNLPKFVFEDVPLFLGLISDLFPGLDCPRVRYPDFNDAVEQVLEENGYAVLPIQVDKVVQMFETMLTRHTTMVVGPTRGGKSVVINTLCQAQTKLGLTTKLYILNPKAVSVIELYGILDPTTRDWTDGVLSNIFREINKPTDKKERKYILFDGDVDALWVENMNSVMDDNRLLTLANGERIRLQAHCALLFEVGDLQYASPATVSRCGMVYVDPKNLKYRPYWKKWVNQIPNKVEQYNLNSLFEKYVPYLMDVIVEGIVDGRQAEKLKTIVPQTDLNMVTQLAKMLDALLEGEIEDLDLLECYFLEALYCSLGASLLEDGRMKFDEYIKRLASLSTVDTEGVWANPGELPGQLPTLYDFHFDNKRNQWVPWSKLVPEYIHAPERKFINILVHTVDTTRTTWILEQMVKIKQPVIFVGESGTSKTATTQNFLKNLSEETNIVLMVNFSSRTTSMDIQRNLEANVEKRTKDTYGPPMGKRLLVFMDDMNMPRVDEYGTQQPIALLKLLLEKGYLYDRGKELNCKSIRDLGFIAAMGKAGGGRNEVDPRFISLFSVFNVPFPSEESLHLIYSSILKGHTSTFHESIVAVSGKLTFCTLALYKNIVQDLPPTPSKFHYIFNLRDLSRVFNGLVLTNPERFQTVAQMVRVWRNECLRVFHDRLISETDKQLVQQHIGSLVVEHFKDDVEVVMRDPILFGDFQMALHEGEPRIYEDIQDYEAAKALFQEILEEYNESNTKMNLVLFDDALEHLTRVHRIIRMDRGHALLVGVGGSGKQSLSRLAAFTASCEVFEILLSRGYSENSFREDLKSLYLKLGIENKAMIFLFTDAHVAEEGFLELINNMLTSGIVPALFSEEEKESILSQIGQEALKQGMGPAKESVWQYFVNKSANNLHIVLGMSPVGDTLRTWCRNFPGMVNNTGIDWFMPWPPQALHAVAKSFLGYNPMIPAENIENVVKHVVLVHQSVDHYSQQFLQKLRRSNYVTPKNYLDFINTYSKLLDEKTQCNIAQCKRLDGGLDKLKEATIQLDELNQKLAEQKIVLAEKSAACEALLEEIAVNTAVAEEKKKLAEEKAMEIEEQNKVIAMEKAEAETTLAEVMPILEAAKLELQKLDKSDVTEIRSFAKPPKQVQTVCECILIMKGYKELNWKTAKGVMSDPNFLRSLMEIDFDSITQSQVKNIKGLLKTLNTTTEEMEAVSKAGLGMLKFVEAVMGYCDVFREIKPKREKVARLERNFYLTKRELERIQNELAAIQKELETLGAKYEAAILEKQKLQEEAEIMERRLIAADKLISGLGSENIRWLNDLDELMHRRVKLLGDCLLCAAFLSYEGAFTWEFRDEMVNRIWQNDILEREIPLSQPFRLESLLTDDVEISRWGSQGLPPDELSVQNGILTTRASRFPLCIDPQQQALNWIKRKEEKNNLRVASFNDPDFLKQLEMSIKYGTPFLFRDVDEYIDPVIDNVLEKNIKVSQGRQFIILGDKEVDYDSNFRLYLNTKLANPRYSPSVFGKAMVINYTVTLKGLEDQLLSVLVAYERRELEEQREHLIQETSENKNLLKDLEDSLLRELATSTGNMLDNVDLVHTLEETKSKATEVSEKLKLAEKTALDIDRLRDGYRPAARRGAILFFVLSEMALVNSMYQYSLIAFLEVFRLSLKKSLPDSILMKRLRNIMDTLTFSIYNHGCTGLFERHKLLFSFNMTIKIEQAEGRVPQEELDFFLKGNISLEKSKRKKPCAWLSDQGWEDIILLSEMFSDNFGQLPDDVENNQTVWQEWYDLDSLEQFPVPLGYDNNITPFQKLLILRCFRVDRVYRAVTDYVTVTMGEKYVQPPMISFEAIFEQSTPHSPIVFILSPGSDPATDLMKLAERSGFGGNRLKFLAMGQGQEKVALQLLETAVARGQWLMLQNCHLLVKWLKDLEKSLERITKPHPDFRLWLTTDPTKGFPIGILQKSLKVVTEPPNGLKLNMRATYFKISHEMLDQCPHPAFKPLVYVLAFFHAVVQERRKFGKIGWNVYYDFNESDFQVCMEILNTYLTKAFQQRDPRIPWGSLKYLIGEVMYGGRAIDSFDRRILTIYMDEYLGDFIFDTFQPFHFFRNKEVDYKIPVGDEKEKFVEAIEALPLANTPEVFGLHPNAEIGYYTQAARDMWAHLLELQPQTGESSSGISRDDYIGQVAKEIENKMPKVFDLDQVRKRLGTGLSPTSVVLLQELERFNKLVVRMTKSLAELQRALAGEVGMSNELDDVARSLFIGHIPNIWRRLAPDTLKSLGNWMVYFLRRFSQYMLWVTESEPSVMWLSGLHIPESYLTALVQATCRKNGWPLDRSTLFTQVTKFQDADEVNERAGQGCFVSGLYLEGADWDIEKGCLIKSKPKVLVVDLPILKIIPIEAHRLKLQNTFRTPVYTTSMRRNAMGVGLVFEADLFTTRHISHWVLQGVCLTLNSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
46PhosphorylationAKRVSLRTESLGQPL
HHHHHCCHHCCCCCC		34.9125693802
48PhosphorylationRVSLRTESLGQPLNR
HHHCCHHCCCCCCCC		36.8725693802
65PhosphorylationEEMDKEISEKLPSKR
HHHHHHHHHHCCCHH		29.75-
70PhosphorylationEISEKLPSKRTAKHI
HHHHHCCCHHHHHHH		45.2524719451
73PhosphorylationEKLPSKRTAKHIMEK
HHCCCHHHHHHHHHH		43.7426270265
312PhosphorylationVLDVIKESDSMLVAN
HHHHHHHCCCCHHHC		29.9521601212
352PhosphorylationERYFKNITHGSGFHV
HHHHCCCCCCCCCEE		29.5825332170
355PhosphorylationFKNITHGSGFHVVLD
HCCCCCCCCCEEHHH		30.5925332170
410PhosphorylationCRVVNLRTLFKENRA
HHHHCHHHHHHHCCC		39.4520068231
418PhosphorylationLFKENRASAQSKTLE
HHHHCCCCHHHHHHH		24.4920068231
421PhosphorylationENRASAQSKTLEARN
HCCCCHHHHHHHHHH		27.5920068231
437PhosphorylationLRLWKKAYFDTRAKI
HHHHHHHHHHHHHHH		15.7430108239
440PhosphorylationWKKAYFDTRAKIEAS
HHHHHHHHHHHHHHC		23.7224719451
447PhosphorylationTRAKIEASGREDRWE
HHHHHHHCCCCCCCC		26.1226437602
598PhosphorylationEVQEILDSDRGQEVK
HHHHHHCCCCCHHHH		26.2620068231
623PhosphorylationKEYEDRKYEQWMEVT
HHHHHHHHHHHHHHH		17.78-
630PhosphorylationYEQWMEVTEQVLPAL
HHHHHHHHHHHHHHH		13.85-
641PhosphorylationLPALMKKSLLTKSSI
HHHHHHHHCCCCCCC		24.0824719451
705PhosphorylationEDKFLRYTAGIQRML
CCHHHHHHHHHHHHH		16.3920068231
734PhosphorylationSVLLKDHSQELLRVF
HHHCCCCCHHHHHHH		35.1729759185
869PhosphorylationKYWEKKIYEVLTKLI
HHHHHHHHHHHHHHH		14.6324505115
873PhosphorylationKKIYEVLTKLILKNL
HHHHHHHHHHHHHCH		29.0424505115
1004AcetylationRPLWKLDKAIVMEKF
CCHHHHCHHHHHHHH		50.9119666883
1010AcetylationDKAIVMEKFAAKKPP
CHHHHHHHHHCCCCC		23.3919666889
1028PhosphorylationYDEKLQFYSKIAYEV
ECHHHHHHHHHHHHH		8.97-
1033PhosphorylationQFYSKIAYEVMRHPL
HHHHHHHHHHHCCCC		16.72-
1057PhosphorylationQLRHLANTVQENAKS
HHHHHHHHHHHHHHH		20.2628152594
1074N-linked_GlycosylationISLGKLLNESAKEEL
HHHHHHHCHHHHHHH		52.1719159218
1111PhosphorylationDLKFVLATIAEIRSK
HHHHHHHHHHHHHCC		19.2922210691
1117PhosphorylationATIAEIRSKSLVMEL
HHHHHHHCCCHHHHH		32.0522210691
1183PhosphorylationKRTFTELTRGEIMNY
HHHHHHHHCCCHHEE		30.3228555341
1199UbiquitinationVQIEEFAKRFYSEGP
HHHHHHHHHHHCCCC		48.65-
1318PhosphorylationPVRGLSVTYYLEAKM
CCCCCEEEHHHHHHH		11.76-
1320PhosphorylationRGLSVTYYLEAKMKA
CCCEEEHHHHHHHHH		6.68-
1521PhosphorylationFKRIMGETLKDPVIK
HHHHHCCCCCCHHHH		33.12-
1523UbiquitinationRIMGETLKDPVIKRC
HHHCCCCCCHHHHHH		68.36-
1528UbiquitinationTLKDPVIKRCCEAPN
CCCCHHHHHHHCCCC		39.35-
1596PhosphorylationQEHMIKMYDNIASLR
HHHHHHHHHCCCCCE		10.80-
1601PhosphorylationKMYDNIASLRFNDGD
HHHHCCCCCEECCCC		19.1129262532
1609PhosphorylationLRFNDGDSGEKLVSA
CEECCCCCCHHHHHH		55.1522210691
1711PhosphorylationEKQAMKNYGRKMHRQ
HHHHHHHHHHHHHHH		16.8818083107
1731PhosphorylationTRITMPLSKNDRKKY
HHHCCCCCCCCHHHC		24.4420058876
1740PhosphorylationNDRKKYNTVLIIDVH
CCHHHCCEEEEEEEE		17.38-
1986PhosphorylationKTLAKKMTVLYKLAR
HHHHHHHHHHHHHHH		19.08-
2002PhosphorylationQLSKQYHYDFGLRAL
HHHHHHCHHHHHHHH		14.1828787133
2102PhosphorylationKVVQMFETMLTRHTT
HHHHHHHHHHHCCEE		13.2524043423
2105PhosphorylationQMFETMLTRHTTMVV
HHHHHHHHCCEEEEE		15.0220068231
2120PhosphorylationGPTRGGKSVVINTLC
CCCCCCCCHHHHHHH		25.54-
2279O-linked_GlycosylationVEQYNLNSLFEKYVP
HHHCCHHHHHHHHHH		37.2929351928
2416PhosphorylationWSKLVPEYIHAPERK
HHHCCCCHHCCCCHH		7.61-
2457PhosphorylationPVIFVGESGTSKTAT
CEEEECCCCCCCCHH		41.25-
2459PhosphorylationIFVGESGTSKTATTQ
EEECCCCCCCCHHHH		36.01-
2460PhosphorylationFVGESGTSKTATTQN
EECCCCCCCCHHHHH		31.38-
2495MethylationTTSMDIQRNLEANVE
CCCHHHHHHHHHHHH		50.46-
2508PhosphorylationVEKRTKDTYGPPMGK
HHHHCCCCCCCCCCC		31.7522210691
2608PhosphorylationSLHLIYSSILKGHTS
HHHHHHHHHHCCCCC		18.2424719451
2625PhosphorylationHESIVAVSGKLTFCT
HHHHHHHHCCCCHHH		22.07-
2746PhosphorylationHEGEPRIYEDIQDYE
CCCCCCHHHCCCCHH		14.6126074081
2752PhosphorylationIYEDIQDYEAAKALF
HHHCCCCHHHHHHHH		7.3526074081
2809MethylationVGVGGSGKQSLSRLA
EECCCCCHHHHHHHH		38.11-
3022PhosphorylationNYVTPKNYLDFINTY
CCCCCHHHHHHHHHH		17.4929978859
3028PhosphorylationNYLDFINTYSKLLDE
HHHHHHHHHHHHHCH		25.1029978859
3029PhosphorylationYLDFINTYSKLLDEK
HHHHHHHHHHHHCHH		10.1829978859
3030PhosphorylationLDFINTYSKLLDEKT
HHHHHHHHHHHCHHC		18.1329978859
3291PhosphorylationAIQKELETLGAKYEA
HHHHHHHHHHHHHHH		43.0220068231
3296PhosphorylationLETLGAKYEAAILEK
HHHHHHHHHHHHHHH		15.40-
3325PhosphorylationIAADKLISGLGSENI
HHHHHHHHCCCHHCC		38.1027174698
3329PhosphorylationKLISGLGSENIRWLN
HHHHCCCHHCCHHHC		32.2927174698
3426PhosphorylationSVQNGILTTRASRFP
HEECCEEECCHHCCC		16.59-
3595PhosphorylationLLKDLEDSLLRELAT
HHHHHHHHHHHHHHH		21.6724719451
3622PhosphorylationHTLEETKSKATEVSE
CCHHHHHHHHHHHHH		34.64-
3625PhosphorylationEETKSKATEVSEKLK
HHHHHHHHHHHHHHH		40.43-
3628PhosphorylationKSKATEVSEKLKLAE
HHHHHHHHHHHHHHH		23.84-
3728PhosphorylationERHKLLFSFNMTIKI
HHCCEEEEEEEEEEE		18.7120068231
3732PhosphorylationLLFSFNMTIKIEQAE
EEEEEEEEEEEEECC		21.8820068231
3856MethylationVTVTMGEKYVQPPMI
EEEECCCCCCCCCEE		45.0223644510
4062PhosphorylationVCMEILNTYLTKAFQ
HHHHHHHHHHHHHHH		19.23-
4063PhosphorylationCMEILNTYLTKAFQQ
HHHHHHHHHHHHHHC		15.99-
4065PhosphorylationEILNTYLTKAFQQRD
HHHHHHHHHHHHCCC		15.20-
4425PhosphorylationHRLKLQNTFRTPVYT
HHHCCCCCCCCCCCC		11.0924719451
4428PhosphorylationKLQNTFRTPVYTTSM
CCCCCCCCCCCCHHH		16.9622210691
4434PhosphorylationRTPVYTTSMRRNAMG
CCCCCCHHHCCCCCC		11.5124719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DYH10_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DYH10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DYH10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DYH10_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DYH10_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1074, AND MASSSPECTROMETRY.

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