dbPTM

DUS6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DUS6_MOUSE
UniProt AC	Q9DBB1
Protein Name	Dual specificity protein phosphatase 6
Gene Name	Dusp6
Organism	Mus musculus (Mouse).
Sequence Length	381
Subcellular Localization	Cytoplasm .
Protein Description	Inactivates MAP kinases. Has a specificity for the ERK family (By similarity). Plays an important role in alleviating acute postoperative pain. [PubMed: 24155322]
Protein Sequence	MIDTLRPVPFASEMAICKTVSWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPTPQLYFTTPSNQNVYQVDSLQST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
159	Phosphorylation	DGSCSSSSPPLPVLG CCCCCCCCCCCCEEE	32.27	-
174	Phosphorylation	LGGLRISSDSSSDIE ECCEEECCCCCCHHH	38.86	21743459
176	Phosphorylation	GLRISSDSSSDIESD CEEECCCCCCHHHHH	33.42	21743459
177	Phosphorylation	LRISSDSSSDIESDL EEECCCCCCHHHHHC	36.70	21743459
178	Phosphorylation	RISSDSSSDIESDLD EECCCCCCHHHHHCC	46.70	21149613
182	Phosphorylation	DSSSDIESDLDRDPN CCCCHHHHHCCCCCC	43.75	21743459
197	Phosphorylation	SATDSDGSPLSNSQP CCCCCCCCCCCCCCC	27.88	-
235	Phosphorylation	LEEFGIKYILNVTPN HHHHCCEEEEECCCC	14.55	26745281
240	Phosphorylation	IKYILNVTPNLPNLF CEEEEECCCCCCHHH	12.84	26745281
328	Phosphorylation	DIVKMKKSNISPNFN HHHHHHHCCCCCCCC	33.60	27087446
331	Phosphorylation	KMKKSNISPNFNFMG HHHHCCCCCCCCHHH	20.31	27087446
350	Phosphorylation	FERTLGLSSPCDNRV HHHHHCCCCCCCCCC	30.36	28066266
351	Phosphorylation	ERTLGLSSPCDNRVP HHHHCCCCCCCCCCC	34.29	21743459

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
159	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
159	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
197	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
197	S	Phosphorylation	Kinase	MAPK3	P27361	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DUS6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DUS6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DUS6_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DUS6_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, AND MASSSPECTROMETRY.	19131326 [Abstract]