DUS1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DUS1_RAT
• UniProt AC: Q64623
• Protein Name: Dual specificity protein phosphatase 1 {ECO:0000305}
• Gene Name: Dusp1 {ECO:0000312|RGD:620897}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 367
• Subcellular Localization: Nucleus .
• Protein Description: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle..
• Protein Sequence: MVMEVGILDAGGLRALLRERAAQCLLLDCRSFFAFNAGHIVGSVNVRFSTIVRRRAKGAMGLEHIVPNTELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARSTQVFFLQGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILSFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKDAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHPTNSALNYLQSPITTSPSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
359	Phosphorylation	SALNYLQSPITTSPS CHHHHHCCCCCCCCC	18.70	-
364	Phosphorylation	LQSPITTSPSC---- HCCCCCCCCCC----	13.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
359	S	Phosphorylation	Kinase	MAPK1	P63086	Uniprot
359	S	Phosphorylation	Kinase	MAPK3	P21708	Uniprot
364	S	Phosphorylation	Kinase	MAPK1	P63086	Uniprot
364	S	Phosphorylation	Kinase	MAPK3	P21708	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	Fbxo32	Q91Z62	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
359	S	Phosphorylation	Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.	-
364	S	Phosphorylation	Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DUS1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_RAT	Ubc	physical	16301819

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.