DUS15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DUS15_HUMAN
• UniProt AC: Q9H1R2
• Protein Name: Dual specificity protein phosphatase 15 {ECO:0000312|HGNC:HGNC:16236}
• Gene Name: DUSP15 {ECO:0000312|HGNC:HGNC:16236}
• Organism: Homo sapiens (Human).
• Sequence Length: 295
• Subcellular Localization: Cytoplasm .; Isoform 3: Cell membrane; Lipid-anchor; Cytoplasmic side.
• Protein Description: May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6. [PubMed: 22792334; Isoform 3: May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (By similarity Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity]
• Protein Sequence: MTEGVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 3)	Myristoylation	-	41.25	15138252
76 (in isoform 4)	Phosphorylation	-	4.33	24114839
78 (in isoform 4)	Phosphorylation	-	33.03	24043423
79 (in isoform 4)	Phosphorylation	-	22.17	24114839
81 (in isoform 4)	Phosphorylation	-	4.80	24114839
82 (in isoform 4)	Phosphorylation	-	3.23	24043423
87 (in isoform 4)	Phosphorylation	-	21.58	24043423
90 (in isoform 4)	Phosphorylation	-	21.18	24043423
93 (in isoform 4)	Phosphorylation	-	21.30	24043423
174	Phosphorylation	AARVALLSAALVREA HHHHHHHHHHHHHHH	16.61	28102081
176 (in isoform 2)	Phosphorylation	-	11.83	24114839
178 (in isoform 2)	Phosphorylation	-	4.45	24043423
179 (in isoform 2)	Phosphorylation	-	28.78	24114839
179 (in isoform 3)	Phosphorylation	-	28.78	24114839
181 (in isoform 2)	Phosphorylation	-	12.56	24114839
181 (in isoform 3)	Phosphorylation	-	12.56	24043423
182 (in isoform 3)	Phosphorylation	-	23.57	24114839
182 (in isoform 2)	Phosphorylation	-	23.57	24043423
182	Phosphorylation	AALVREATGRTAQRC HHHHHHHHCCCCHHC	23.57	21712546
184 (in isoform 3)	Phosphorylation	-	23.64	24114839
185 (in isoform 3)	Phosphorylation	-	28.61	24043423
187 (in isoform 2)	Phosphorylation	-	44.38	24043423
190 (in isoform 3)	Phosphorylation	-	40.15	24043423
190 (in isoform 2)	Phosphorylation	-	40.15	24043423
193 (in isoform 3)	Phosphorylation	-	34.22	24043423
193 (in isoform 2)	Phosphorylation	-	34.22	24043423
196 (in isoform 3)	Phosphorylation	-	15.90	24043423
252	Phosphorylation	VQLRPGSSSCTLSAS EEECCCCCCEEEEEE	35.03	-
253	Phosphorylation	QLRPGSSSCTLSAST EECCCCCCEEEEEEE	16.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DUS15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DUS15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DUS15_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DUS15_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.