| UniProt ID | DSC1_MOUSE | |
|---|---|---|
| UniProt AC | P55849 | |
| Protein Name | Desmocollin-1 | |
| Gene Name | Dsc1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 886 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. Cell junction, desmosome. |
|
| Protein Description | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.. | |
| Protein Sequence | MAVACAAPGSTFSKQLLFFLLVLVLFCDACQKVSLHVPSHLKAETPVGKVNLEECLKSPSLILSSDPAFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKLEVVLSAREKKVFRKRHTKEPVHNRSKRRWAPIPCSLMENSLGPFPQHIQQIQSDAAQNYTIFYSISGPGVDKEPYNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTADGYAPDYPLPLLFKVEDDNDNAPYFETKLTVFSVPENCRSGTSVGQVTAIDKDEPGTLHTRLKYKILQQIPDQPKHFSIHPDTGVITTTTPLLDREKCDTYKLVMEVRDMGGQPFGLFTTGTITISLEDENDNSPYFTQTSYTTEVEENRIDVEILRMVVHDQDLPNTPHSKAVYTILKGNENGNFKITTDPNTNEGVLCVVKPLNYEVSRQVTLQIGVLNEAQFTNAANAQPPTMCTTTVTVKIKDRDEGPECQPPVKVIQSKDGLPAGQELLGYKAVDPETSSGEGLRYEMVGDEDNWFEINKITGDLRTVKVLDRESKFVKNNQYNISVVATDTAGRSCTGTLVVLLEDFNDHPPQIDKEVTICQQEKDFAVLEPIDLDGPDNGPPFQFLLDNSSSKLWTLESQDGKRAILRQRHNLNYNYYSVPIQIQDRHGFSAKHVLSVRVCDCTTPTECRMAVKEERDAKPNIILGKWAILAMVLGSALLLCILFTCFCVTTTKRTVKKCFPDDVAQQNLIVSNTEGPGEEVTEANIRLPTQTANICDTSMSVGTLGGQGIKTQQSFEMVKGGHTLESHKGGVLGAAEPGRYAYTDWQTFTQPRLGEKVYLCGQAEEHKHCEDYVRPYNYEGKGSMAGSVGCCSDRQEEEGLEFLDQLEPKFRTLAKTCVKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 130 | N-linked_Glycosylation | HTKEPVHNRSKRRWA CCCCCCCCCCCCCCC | 50.59 | - | |
| 165 | N-linked_Glycosylation | IQSDAAQNYTIFYSI HHHHHHHCEEEEEEE | 31.05 | - | |
| 385 | Phosphorylation | HDQDLPNTPHSKAVY CCCCCCCCCCCCEEE | 22.05 | - | |
| 431 | Phosphorylation | YEVSRQVTLQIGVLN EEEEEEEEEEEECCC | 12.47 | 25777480 | |
| 443 | Phosphorylation | VLNEAQFTNAANAQP CCCHHHHCCCCCCCC | 16.33 | 25777480 | |
| 452 | Phosphorylation | AANAQPPTMCTTTVT CCCCCCCCEEEEEEE | 31.40 | 25777480 | |
| 455 | Phosphorylation | AQPPTMCTTTVTVKI CCCCCEEEEEEEEEE | 18.06 | 25777480 | |
| 456 | Phosphorylation | QPPTMCTTTVTVKIK CCCCEEEEEEEEEEE | 17.84 | 25777480 | |
| 457 | Phosphorylation | PPTMCTTTVTVKIKD CCCEEEEEEEEEEEC | 8.95 | 25777480 | |
| 459 | Phosphorylation | TMCTTTVTVKIKDRD CEEEEEEEEEEECCC | 17.62 | 25777480 | |
| 524 | Phosphorylation | WFEINKITGDLRTVK EEEEEEHHCCCEEEE | 26.67 | - | |
| 545 | Phosphorylation | KFVKNNQYNISVVAT HHHHCCCEEEEEEEE | 19.31 | 30635358 | |
| 546 | N-linked_Glycosylation | FVKNNQYNISVVATD HHHCCCEEEEEEEEC | 15.42 | 16170054 | |
| 548 | Phosphorylation | KNNQYNISVVATDTA HCCCEEEEEEEECCC | 13.60 | 30635358 | |
| 552 | Phosphorylation | YNISVVATDTAGRSC EEEEEEEECCCCCCC | 23.44 | 30635358 | |
| 613 | N-linked_Glycosylation | PFQFLLDNSSSKLWT CCEEEEECCCCCCEE | 43.70 | - | |
| 780 | Phosphorylation | QGIKTQQSFEMVKGG CCCCCCEEEEEEECC | 17.23 | 23375375 | |
| 789 | Phosphorylation | EMVKGGHTLESHKGG EEEECCCCEEECCCC | 35.18 | 19367708 | |
| 792 | Phosphorylation | KGGHTLESHKGGVLG ECCCCEEECCCCCCC | 33.34 | 19367708 | |
| 828 (in isoform 2) | Phosphorylation | - | 44.60 | - | |
| 849 | Phosphorylation | YNYEGKGSMAGSVGC CCCCCCCCCCCCCCC | 14.67 | - | |
| 853 | Phosphorylation | GKGSMAGSVGCCSDR CCCCCCCCCCCCCCC | 13.05 | - | |
| 858 | Phosphorylation | AGSVGCCSDRQEEEG CCCCCCCCCCCHHHH | 39.65 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DSC1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DSC1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DSC1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of DSC1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "High throughput quantitative glycomics and glycoform-focusedproteomics of murine dermis and epidermis."; Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K.,Monde K., Nishimura S.; Mol. Cell. Proteomics 4:1977-1989(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-546, AND MASSSPECTROMETRY. | |
