DRTS1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRTS1_ARATH
• UniProt AC: Q05762
• Protein Name: Bifunctional dihydrofolate reductase-thymidylate synthase 1
• Gene Name: THY-1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 519
• Protein Description: Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP..
• Protein Sequence: MATTTLNDSVTTTLASEPQRTYQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDITLTTSDSSKKNAVVMGRKTWESIPIKYRPLSGRLNVVLTRSGGFDIANTENVVTCSSVDSALDLLAAPPYCLSIERVFVIGGGDILREALNRPSCDAIHLTEIDTSVDCDTFIPAIDTSVYQPWSSSFPVTENGLRFCFTTFVRVKSSADESSDESNGSQSLQFDGKKFLFLPKMVFDQHEEFLYLNMVEDIISNGNVKNDRTGTGTLSKFGCQMKFNLRRSFPLLTTKRVFWRGVVEELLWFISGSTNAKVLQEKGIHIWDGNASREYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYTGQGFDQLVDVIDKIKNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVAEGELSCQMYQRSADMGLGVPFNIASYSLLTCMLAHVCDLVPGDFIHVLGDAHVYKTHVRPLQEQLLNLPKPFPVMKINPEKKQIDSFVASDFDLTGYDPHKKIEMKMAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATTTLNDS ------CCCCCCCCC	17.41	22223895
5	Phosphorylation	---MATTTLNDSVTT ---CCCCCCCCCCCC	21.14	23328941
69	Sulfoxidation	SKKNAVVMGRKTWES CCCCEEEECCCCCCC	3.27	25693801
201	Phosphorylation	TTFVRVKSSADESSD EEEEEEECCCCCCCC	28.09	30407730
202	Phosphorylation	TFVRVKSSADESSDE EEEEEECCCCCCCCC	33.74	30407730
206	Phosphorylation	VKSSADESSDESNGS EECCCCCCCCCCCCC	43.57	19880383
207	Phosphorylation	KSSADESSDESNGSQ ECCCCCCCCCCCCCE	43.26	19880383
210	Phosphorylation	ADESSDESNGSQSLQ CCCCCCCCCCCEEEE	52.02	30407730
213	Phosphorylation	SSDESNGSQSLQFDG CCCCCCCCEEEEECC	22.35	30407730
215	Phosphorylation	DESNGSQSLQFDGKK CCCCCCEEEEECCEE	26.32	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DRTS1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DRTS1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRTS1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.