DREB_RAT - dbPTM
DREB_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DREB_RAT
UniProt AC Q07266
Protein Name Drebrin
Gene Name Dbn1
Organism Rattus norvegicus (Rat).
Sequence Length 707
Subcellular Localization Cytoplasm . Cytoplasm, cell cortex . Cell junction . Cell projection . Cell projection, growth cone . In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distr
Protein Description Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS (By similarity). Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites..
Protein Sequence MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDARLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQSLEAEEAKRRLKDQSIFGDQRDEEEESQMKKSESEVEEAAAIIAQRPDNPREFFRQQERVASASGGSCDAPSPFNHRPGRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTASTPITEQIERALDEVTSSQPPPPPPPPPPAQEAQESAPRLDGEEVCKEAKVAAAPQVWAGCAEEPPRAQEPPLLQSSPTEDLMCTESPEQAVLAASPEPDASVTSVADAHAADTIETTTATTATTIADNVTPAAASLIDLWPGNGEEASTPQAEPRVPTPPSGAEASLAEVPLLNEAAQEPLPPVGEGCANLLNFDELPEPPATFCDPEEEAEGEPLAASQVLTMPSALEEVDQVLEQELEPEPHLLTNGETTQKEGTQQASEGYFSQSQEEEFAQSEEPCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAGVSFSGH
------CCCCCCCHH		27.39-
5Phosphorylation---MAGVSFSGHRLE
---CCCCCCCHHHHH		16.8722673903
7Phosphorylation-MAGVSFSGHRLELL
-CCCCCCCHHHHHHH		26.6122673903
141PhosphorylationSNGLARLSSPVLHRL
HHHHHHHCCHHHHHH		27.3525403869
142PhosphorylationNGLARLSSPVLHRLR
HHHHHHCCHHHHHHH		24.5023712012
241PhosphorylationEHRRKQQSLEAEEAK
HHHHHHHHHHHHHHH		26.1928432305
272PhosphorylationEESQMKKSESEVEEA
HHHHHHHCHHHHHHH		40.6228432305
274PhosphorylationSQMKKSESEVEEAAA
HHHHHCHHHHHHHHH		54.7728432305
302 (in isoform 2)Phosphorylation-21.8028432305
304 (in isoform 2)Phosphorylation-40.9928432305
307 (in isoform 2)Phosphorylation-16.6128432305
307PhosphorylationVASASGGSCDAPSPF
HHHCCCCCCCCCCCC		16.6125403869
312 (in isoform 2)Phosphorylation-43.7928432305
320 (in isoform 2)Phosphorylation-23.0028432305
324 (in isoform 2)Phosphorylation-28.3128432305
331PhosphorylationPFIKASDSGPSSSSS
CEEECCCCCCCCCCC		50.5425403869
334PhosphorylationKASDSGPSSSSSSSS
ECCCCCCCCCCCCCC		46.5128551015
335PhosphorylationASDSGPSSSSSSSSS
CCCCCCCCCCCCCCC		37.0628551015
336PhosphorylationSDSGPSSSSSSSSSP
CCCCCCCCCCCCCCC		38.2828551015
337PhosphorylationDSGPSSSSSSSSSPP
CCCCCCCCCCCCCCC		35.8728551015
338PhosphorylationSGPSSSSSSSSSPPR
CCCCCCCCCCCCCCC		35.8728551015
339PhosphorylationGPSSSSSSSSSPPRT
CCCCCCCCCCCCCCC		35.8728551015
340PhosphorylationPSSSSSSSSSPPRTP
CCCCCCCCCCCCCCC		36.4628551015
341PhosphorylationSSSSSSSSSPPRTPF
CCCCCCCCCCCCCCC		49.1427097102
342PhosphorylationSSSSSSSSPPRTPFP
CCCCCCCCCCCCCCC		40.6530411139
346PhosphorylationSSSSPPRTPFPYITC
CCCCCCCCCCCEEEE		34.7525403869
377PhosphorylationSHRRMAPTPIPTRSP
CCCCCCCCCCCCCCC		25.0628432305
381PhosphorylationMAPTPIPTRSPSDSS
CCCCCCCCCCCCCCC		44.4927097102
383PhosphorylationPTPIPTRSPSDSSTA
CCCCCCCCCCCCCCC		31.1023712012
385PhosphorylationPIPTRSPSDSSTAST
CCCCCCCCCCCCCCC		51.9023712012
387PhosphorylationPTRSPSDSSTASTPI
CCCCCCCCCCCCCCH		33.6527097102
388PhosphorylationTRSPSDSSTASTPIT
CCCCCCCCCCCCCHH		32.7427097102
389PhosphorylationRSPSDSSTASTPITE
CCCCCCCCCCCCHHH		28.6927097102
391PhosphorylationPSDSSTASTPITEQI
CCCCCCCCCCHHHHH		34.5027097102
392PhosphorylationSDSSTASTPITEQIE
CCCCCCCCCHHHHHH		19.0827097102
395PhosphorylationSTASTPITEQIERAL
CCCCCCHHHHHHHHH		24.0427097102
467PhosphorylationEPPLLQSSPTEDLMC
CCCCCCCCCCCCCCC		23.9230240740
549PhosphorylationQAEPRVPTPPSGAEA
CCCCCCCCCCCCCCC		45.0030240740
552PhosphorylationPRVPTPPSGAEASLA
CCCCCCCCCCCCCHH		52.4130240740
648PhosphorylationETTQKEGTQQASEGY
CCCCCCCCHHHHHCC		20.7128551015
652PhosphorylationKEGTQQASEGYFSQS
CCCCHHHHHCCCCHH		27.5028551015
655PhosphorylationTQQASEGYFSQSQEE
CHHHHHCCCCHHHHH		8.9428432305
657PhosphorylationQASEGYFSQSQEEEF
HHHHCCCCHHHHHHH		22.0428432305
659PhosphorylationSEGYFSQSQEEEFAQ
HHCCCCHHHHHHHHH		38.0627097102
667PhosphorylationQEEEFAQSEEPCAKA
HHHHHHHCCCCHHCC		40.2628551015
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
142SPhosphorylationKinaseCDK5Q03114
PSP
659SPhosphorylationKinaseATMD4ACL8
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DREB_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DREB_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DREB_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DREB_RAT

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Related Literatures of Post-Translational Modification

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