DRE2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRE2_SCHPO
• UniProt AC: O74821
• Protein Name: Fe-S cluster assembly protein dre2 {ECO:0000255|HAMAP-Rule:MF_03115}
• Gene Name: dre2 {ECO:0000255|HAMAP-Rule:MF_03115}
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 288
• Subcellular Localization: Cytoplasm . Mitochondrion intermembrane space .
• Protein Description: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit suc22..
• Protein Sequence: MSSSVLVLTSPGFASKEESLKKVFDLIDNGASRELQMIDRVQSQLVNLPINRYDSVIAAIDDGAWSSTLGPILSQAFASVHPGGTLRVYSTADEADESFEMTALLSGWLIESKSPWILSRPNQVEAVPIKLSNKNGQSASKNKILDFLKSDKENLISGDDDQELIDEDELLDESAHDNVLKVPECKPEPGKKKRACKNCTCGLREMEEHESSKTSAQLEAVKLTDTTEVDFTEKLKSKNAVSSCGNCYLGDAFRCSGCPYIGMPAFNPGDTVILAENRDKMSWMADDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSSVLVLT ------CCCEEEEEC	31.18	21712547
9	Phosphorylation	SSSVLVLTSPGFASK CCEEEEECCCCCCCH	25.95	21712547
10	Phosphorylation	SSVLVLTSPGFASKE CEEEEECCCCCCCHH	20.90	21712547
15	Phosphorylation	LTSPGFASKEESLKK ECCCCCCCHHHHHHH	38.04	21712547
157	Phosphorylation	SDKENLISGDDDQEL HCHHHCCCCCCCHHH	39.06	29996109
282	Phosphorylation	AENRDKMSWMADDI- ECCHHHHCCCCCCC-	21.31	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DRE2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DRE2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRE2_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of DRE2_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.