DRAM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRAM2_HUMAN
• UniProt AC: Q6UX65
• Protein Name: DNA damage-regulated autophagy modulator protein 2
• Gene Name: DRAM2
• Organism: Homo sapiens (Human).
• Sequence Length: 266
• Subcellular Localization: Lysosome membrane ; Multi-pass membrane protein . Photoreceptor inner segment . Apical cell membrane . Localized to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells.
• Protein Description: Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1..
• Protein Sequence: MWWFQQGLSFLPSALVIWTSAAFIFSYITAVTLHHIDPALPYISDTGTVAPEKCLFGAMLNIAAVLCIATIYVRYKQVHALSPEENVIIKLNKAGLVLGILSCLGLSIVANFQKTTLFAAHVSGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSALSMLTCSSVLHSGNFGTDLEQKLHWNPEDKGYVLHMITTAAEWSMSFSFFGFFLTYIRDFQKISLRVEANLHGLTLYDTAPCPINNERTRLLSRDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
245	Phosphorylation	EANLHGLTLYDTAPC EEECCCCEEEECCCC	28.06	26356563
247	Phosphorylation	NLHGLTLYDTAPCPI ECCCCEEEECCCCCC	13.15	28796482
249	Phosphorylation	HGLTLYDTAPCPINN CCCEEEECCCCCCCC	20.95	28796482
259	Phosphorylation	CPINNERTRLLSRDI CCCCCHHHHHHHCCC	21.35	26074081
263	Phosphorylation	NERTRLLSRDI---- CHHHHHHHCCC----	32.28	28355574

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DRAM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DRAM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRAM2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DRAM2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, AND MASSSPECTROMETRY.
PubMed: 18669648