DPYL5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPYL5_RAT
• UniProt AC: Q9JHU0
• Protein Name: Dihydropyrimidinase-related protein 5
• Gene Name: Dpysl5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 564
• Subcellular Localization: Cytoplasm.
• Protein Description: May have a function in neuronal differentiation and/or axon growth..
• Protein Sequence: MLANSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVEAYEKCRALADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVFHACRDFGAIPRVHAENGELVAEGAKEALDLGITGPEGIEISHPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTNAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVVWERGVVGGKMDENRFVAVTSSNAAKILNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDIVYKKLVQREKTLKVRGVDRTPYLGDVAVVVNPGKKEMGTPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	ASVRILIKGGKVVND CEEEEEEECCEEECC	59.16	-
49	Acetylation	LMIPGGAKVIDATGK EEECCCCEEEECCCC	42.89	22902405
142	Acetylation	TWWAPKVKAEMETLV CEECHHHHHHHHHHH	44.76	22902405
156	Phosphorylation	VREKGVNSFQMFMTY HHHHCCCCEEEEEEH	17.91	27097102
332	Ubiquitination	DHRPFTTKQKAMGKE CCCCCCCCCCCCCCC	46.90	-
338	Acetylation	TKQKAMGKEDFTKIP CCCCCCCCCCHHCCC	40.81	22902405
490	Phosphorylation	KVRGVDRTPYLGDVA CCCCCCCCCCCCCEE	16.30	30240740
492	Phosphorylation	RGVDRTPYLGDVAVV CCCCCCCCCCCEEEE	23.78	25403869
504	Acetylation	AVVVNPGKKEMGTPL EEEECCCCCCCCCCC	46.98	22902405
504	Ubiquitination	AVVVNPGKKEMGTPL EEEECCCCCCCCCCC	46.98	-
505	Ubiquitination	VVVNPGKKEMGTPLA EEECCCCCCCCCCCC	59.87	-
509	Phosphorylation	PGKKEMGTPLADTPT CCCCCCCCCCCCCCC	17.51	30411139
514	Phosphorylation	MGTPLADTPTRPVTR CCCCCCCCCCCCCCC	22.43	30411139
516	Phosphorylation	TPLADTPTRPVTRHG CCCCCCCCCCCCCCC	50.09	30240740
520	Phosphorylation	DTPTRPVTRHGGMRD CCCCCCCCCCCCCCC	21.45	28551015
531	Phosphorylation	GMRDLHESSFSLSGS CCCCCCCCCEECCCC	26.40	28432305
532	Phosphorylation	MRDLHESSFSLSGSQ CCCCCCCCEECCCCC	18.83	25403869
534	Phosphorylation	DLHESSFSLSGSQID CCCCCCEECCCCCCC	24.47	30411139
536	Phosphorylation	HESSFSLSGSQIDDH CCCCEECCCCCCCCC	34.89	30240740
538	Phosphorylation	SSFSLSGSQIDDHVP CCEECCCCCCCCCCC	22.16	28432305
559	Methylation	ILAPPGGRSSGIW-- EECCCCCCCCCCC--	33.30	-
561	Phosphorylation	APPGGRSSGIW---- CCCCCCCCCCC----	32.70	22276854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPYL5_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPYL5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPYL5_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of DPYL5_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.