DPYL3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPYL3_RAT
• UniProt AC: Q62952
• Protein Name: Dihydropyrimidinase-related protein 3
• Gene Name: Dpysl3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 570
• Subcellular Localization: Cytoplasm . Cell projection, growth cone . Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
• Protein Description: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration..
• Protein Sequence: MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVMPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLSKEKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQARMLEMGITGPEGHVLSRPEELEAEAVFRAITVASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDSDLVIWDPDAVKIVSAKNHQSVAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSTRGSPTRPNPPVRNLHQSGFSLSGTQVDEGVRSASKRIVAPPGGRSNITSLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10 (in isoform 2)	Phosphorylation	-	30.89	27097102
11 (in isoform 2)	Phosphorylation	-	40.81	27097102
13	Phosphorylation	KKNIPRITSDRLLIK CCCCCCCCCCCEEEE	26.34	22673903
14	Phosphorylation	KNIPRITSDRLLIKG CCCCCCCCCCEEEEC	20.54	22673903
32	Phosphorylation	VNDDQSFYADIYMED CCCCCCCEEEEEECC	14.49	19652227
56	Acetylation	LIVPGGVKTIEANGK EEECCCEEEEEECCE	47.24	22902405
94 (in isoform 2)	Phosphorylation	-	38.19	27097102
101	Phosphorylation	KAALAGGTTMIIDHV HHHHCCCCEEEEECC	16.57	-
101 (in isoform 2)	Phosphorylation	-	16.57	27097102
102	Phosphorylation	AALAGGTTMIIDHVV HHHCCCCEEEEECCC	15.06	-
157	Ubiquitination	QEVQNLSKEKGVNSF HHHHHHHHHHCCCCH	67.61	-
157	Acetylation	QEVQNLSKEKGVNSF HHHHHHHHHHCCCCH	67.61	22902405
258	Succinylation	YVTKVMSKSAADLIS EEEECCCCCHHHHHH	26.47	-
259	Phosphorylation	VTKVMSKSAADLISQ EEECCCCCHHHHHHH	22.76	28432305
316	Nitrated tyrosine	PDPTTPDYINSLLAS CCCCCHHHHHHHHHH	11.82	-
345	Acetylation	TAQKAIGKDNFTAIP HHHHHHCCCCCEECC	43.30	22902405
345	Ubiquitination	TAQKAIGKDNFTAIP HHHHHHCCCCCEECC	43.30	-
384	Phosphorylation	ENQFVAVTSTNAAKI CCCEEEEEECCHHHH	21.79	25403869
385	Phosphorylation	NQFVAVTSTNAAKIF CCEEEEEECCHHHHC	17.05	25403869
386	Phosphorylation	QFVAVTSTNAAKIFN CEEEEEECCHHHHCC	21.36	25403869
431	Phosphorylation	NHQSVAEYNIFEGME CCCCHHEEECCCCCC	12.10	-
487	Ubiquitination	KRIKARRKMADLHAV HHHHHHHHHHCCCCC	32.65	-
499	Phosphorylation	HAVPRGMYDGPVFDL CCCCCCCCCCCEEEE	22.14	-
507	Phosphorylation	DGPVFDLTTTPKGGT CCCEEEEECCCCCCC	30.39	29779826
508	Phosphorylation	GPVFDLTTTPKGGTP CCEEEEECCCCCCCC	48.69	27097102
509	Phosphorylation	PVFDLTTTPKGGTPA CEEEEECCCCCCCCC	20.12	15466863
514	Phosphorylation	TTTPKGGTPAGSTRG ECCCCCCCCCCCCCC	20.73	30411139
518	Phosphorylation	KGGTPAGSTRGSPTR CCCCCCCCCCCCCCC	19.62	30411139
519	Phosphorylation	GGTPAGSTRGSPTRP CCCCCCCCCCCCCCC	37.82	27097102
522	Phosphorylation	PAGSTRGSPTRPNPP CCCCCCCCCCCCCCC	21.58	15466863
524	Phosphorylation	GSTRGSPTRPNPPVR CCCCCCCCCCCCCCC	61.53	27097102
536	Phosphorylation	PVRNLHQSGFSLSGT CCCCCCCCCCCCCCC	30.93	23984901
539	Phosphorylation	NLHQSGFSLSGTQVD CCCCCCCCCCCCCCC	25.75	23984901
541	Phosphorylation	HQSGFSLSGTQVDEG CCCCCCCCCCCCCHH	38.30	23984901
543	Phosphorylation	SGFSLSGTQVDEGVR CCCCCCCCCCCHHHH	23.26	27097102
563	Asymmetric dimethylarginine	IVAPPGGRSNITSLS EECCCCCCCCCCCCC	32.23	-
567	Phosphorylation	PGGRSNITSLS---- CCCCCCCCCCC----	28.06	28551015
568	Phosphorylation	GGRSNITSLS----- CCCCCCCCCC-----	23.87	28551015
570	Phosphorylation	RSNITSLS------- CCCCCCCC-------	37.63	28551015

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
32	Y	Phosphorylation	Kinase	FYN	P06241	PSP
509	T	Phosphorylation	Kinase	GSK3A	P18265	PSP
509	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
514	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
518	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
518	S	Phosphorylation	Kinase	GSK3	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
509	T	Phosphorylation	Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.	22673903
514	T	Phosphorylation	Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.	22673903
518	S	Phosphorylation	Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.	-
522	S	Phosphorylation	Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.	22673903

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPYL3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of DPYL3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.