| UniProt ID | DPY27_CAEEL | |
|---|---|---|
| UniProt AC | P48996 | |
| Protein Name | Chromosome condensation protein dpy-27 | |
| Gene Name | dpy-27 | |
| Organism | Caenorhabditis elegans. | |
| Sequence Length | 1469 | |
| Subcellular Localization | Nucleus . Chromosome . In interphase cells, diffusely distributed in nuclei before the onset of dosage compensation (PubMed:19119011). Associates with chromatin after the 30-cell stage when dosage compensation is initiated (PubMed:7954812, PubMed:230 | |
| Protein Description | Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development. [PubMed: 7954812] | |
| Protein Sequence | MQPFKRRALTSDDDRPYADTDSMPEVDLDVDRRRQYMEQLNIFDDVSSGAYMLELEAAENGVKYDEKEDLLNVQIPPKYEDQISDPDGNRMIILNIYVENFKSYAGKHILGPFHKNLTMILGPNGSGKSNVIDALLFVFGFKAGKIRTKKLSALINSGGNYESCSVTIMFQMVKDMPVENYDKYEVLTDNCVCITRTINRENNSKYRIDDKDASQKDVQELLLRAGIDMTHNRFLILQGEVEAIALMKPTSKNPNEEGMLEYIEDIVGTNRFVAPISKLMHRVSLLEHKSSQYGASVRRHEGHLKVFEKAMVIGMAYLNTFNNLNYLRGIRVKHNLCRYAETMRDAKMSLVTRTGELEENKDIMLEAKDEVRKKETHERSLNSIVTELENKRIDWQSKKNDWHARDAKRKQGLKSCTQDLGKLMKERDEARREKFEIETAPENARISKQNMQLEWDQLKEQENVCQRTATENLIKYDQKSSADRAKHDDLEKKLSDELLQSMRAKAELDVSESELKDMTIMMEQGQKRVDELKGTLQTMMAENIRDNTELNAVTTELQDRKLKFDKAVEKLPHLKSTEQLLRSKKYELDQEVIEASNTQEVTYRHQATAKLHELKEAGLFPGFKGRLGDLASIPIKFDTAISTVFFAQLDYHVVQTSDECRIGIGFCHEYKLPRTTFVFLDHLKDTDTSGMDSTMKFPAERLFDKIHCVNPEIRREFYFLIHDILVVDSLEEATRIDKKYPGRHRYCTLNGSILNRSGALTGGGKPTTGRIRNDNNPNMSGVKKVDLSKLRAAQEKHNHALEAHLKLQLKQEEIRADNGPIIKQLEIRKRELIMSTKEQKTRIAELKSSIAAHERRMVNYREVTVEDLDEKRAQIADLKRQVEESQKSSAKIKQQIEQYKRKMDRMFMELVQKNKDSIEQAKDRMGQLEQDIARQTAIIENNPSHLEQAEKKLSELEHMCLEKRSEADALAQLEVGEDVKGIDIINAQLQTSTASIDAQRARYTEAVAARREADAAYQTTVDNYNMVKQTYDELMRIIDDLENKTMADNAELDIIESAWMQPEKLYPPGKFVRYNDPDIAAKMTDGHVVLPYECISMIEPHREAYEEHEARMLEDDVFEDTANKICKLEKDVDKFRREFDNKGVRDYAMIVSLLMNEVTSAKKFSDKLKAHREKLNELRMARFNEFSEALAFLGTTTQMLYQLITNGGDASLKFVEEGKSTDPFDGGIKFSVRPAKKSWKLIENLSGGEKTLASLCFVFAMHHYRPTPLYVMDEIDAALDLNNVSLIANYIKHSERTRNAQFIIISLRNQMFEVGNRLLGIYKIDGKTYNIMVDPIAVEIKNRPILKIFEEEIKRREKLRRAEIEPEIDLSNGLSNVVIAPKRKQRRLEMLKLSDFGLDDDSDLPEFNRFPPATRRELSVEDSDEDDEPVRRRPRRQVEEEDEEDELIEEATPSPPPIVVQRRVRRSRH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1419 | Phosphorylation | PATRRELSVEDSDED CCCCCCCCCCCCCCC | 20.78 | 19060867 | |
| 1423 | Phosphorylation | RELSVEDSDEDDEPV CCCCCCCCCCCCCCC | 29.41 | 19060867 | |
| 1452 | Phosphorylation | DELIEEATPSPPPIV HHHHHHCCCCCCCCE | 27.81 | 30078680 | |
| 1454 | Phosphorylation | LIEEATPSPPPIVVQ HHHHCCCCCCCCEEE | 45.76 | 30078680 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DPY27_CAEEL !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DPY27_CAEEL !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DPY27_CAEEL !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of DPY27_CAEEL !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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