| UniProt ID | DP13B_MOUSE | |
|---|---|---|
| UniProt AC | Q8K3G9 | |
| Protein Name | DCC-interacting protein 13-beta | |
| Gene Name | Appl2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 662 | |
| Subcellular Localization |
Early endosome membrane Peripheral membrane protein. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF (By similarity).. |
|
| Protein Description | Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction (By similarity).. | |
| Protein Sequence | MPAVDKLLLEEALQDSPQARSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSRQLLAYEKQNFALGKGDEEVISTLHYFSKVMDELNGLHTELAKQLADTMVLPVIQFREKDLTEVSTLKDLFGLASSEHDLSMAKYSRLPKKKENEKAKTEIVKEVAAARRKQHLSSLQYYCALNALQYRKRAAMMEPLIGFAHGQINFFKRGAEMFSKSMDGFLSSVKDMVQSIQVELEAEADKMRVSQQELLSVSESVYTPDIDVATAQINRNLIQKTGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQISTPSGKPGIILQAESRKEYEEWICAVNNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCSSQNIKNSDIEDDNIVPKATASIPETEELIAPGTPIQFDIVLPATEFLDQNRGGRRTNPFGETEDGSFPEAEDSLLQQMFIVRFLGSMAVKTDSTAEVIYEAMRQVLAARAIHNIFRMTESHLMVTSQTLRLIDPQTQVSRACFELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFESNSEGEKICYAINLGKEIIEVQKDPEALARLMLSVPLTNDGKYVLLNDQADDTGGSPSENRGAESEA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 16 | Phosphorylation | LEEALQDSPQARSLL HHHHHCCCHHHHHHH | 13.12 | 29514104 | |
| 77 | Ubiquitination | KQNFALGKGDEEVIS HHHCCCCCCCHHHHH | 65.13 | - | |
| 127 | Phosphorylation | EKDLTEVSTLKDLFG CCCCCHHHHHHHHHC | 23.07 | 27149854 | |
| 280 | Ubiquitination | INRNLIQKTGYLNLR HHHHHHHHHCCEECC | 36.60 | - | |
| 380 | Phosphorylation | ISRQIYLTDNPEAVA CCCEEEECCCHHHHE | 19.43 | 28576409 | |
| 406 | Ubiquitination | TPITSFGKKQESSCS CCCCCCCCCCCCCCC | 49.63 | - | |
| 410 | Phosphorylation | SFGKKQESSCSSQNI CCCCCCCCCCCCCCC | 33.86 | 23684622 | |
| 411 | Phosphorylation | FGKKQESSCSSQNIK CCCCCCCCCCCCCCC | 19.77 | 23684622 | |
| 413 | Phosphorylation | KKQESSCSSQNIKNS CCCCCCCCCCCCCCC | 36.59 | 23684622 | |
| 420 | Phosphorylation | SSQNIKNSDIEDDNI CCCCCCCCCCCCCCC | 34.66 | 25521595 | |
| 618 | Ubiquitination | KEIIEVQKDPEALAR CCCEEECCCHHHHHH | 79.15 | - | |
| 638 | Phosphorylation | PLTNDGKYVLLNDQA EECCCCCEEEECCCC | 11.23 | 25619855 | |
| 648 | Phosphorylation | LNDQADDTGGSPSEN ECCCCCCCCCCCCCC | 43.95 | 25619855 | |
| 651 | Phosphorylation | QADDTGGSPSENRGA CCCCCCCCCCCCCCC | 26.97 | 25521595 | |
| 653 | Phosphorylation | DDTGGSPSENRGAES CCCCCCCCCCCCCCC | 49.56 | 25619855 | |
| 660 | Phosphorylation | SENRGAESEA----- CCCCCCCCCC----- | 37.99 | 25293948 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DP13B_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DP13B_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DP13B_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of DP13B_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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