DOT2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOT2_ARATH
• UniProt AC: Q9LFE0
• Protein Name: SART-1 family protein DOT2 {ECO:0000305}
• Gene Name: DOT2 {ECO:0000303|PubMed:18643975}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 820
• Subcellular Localization: Nucleus .
• Protein Description: Plays a role in root, shoot and flower development. Probably required for normal root and shoot meristem organization and maintenance and the proper expression of PIN and PLT genes. [PubMed: 19000164 Involved in leaf vasculature patterning]
• Protein Sequence: MEVEKSKSRHEIREERADYEGSPVREHRDGRRKEKDHRSKDKEKDYDREKIRDKDHRRDKEKERDRKRSRDEDTEKEISRGRDKEREKDKSRDRVKEKDKEKERNRHKDRENERDNEKEKDKDRARVKERASKKSHEDDDETHKAAERYEHSDNRGLNEGGDNVDAASSGKEASALDLQNRILKMREERKKKAEDASDALSWVARSRKIEEKRNAEKQRAQQLSRIFEEQDNLNQGENEDGEDGEHLSGVKVLHGLEKVVEGGAVILTLKDQSVLTDGDVNNEIDMLENVEIGEQKRRNEAYEAAKKKKGIYDDKFNDDPGAEKKMLPQYDEAATDEGIFLDAKGRFTGEAEKKLEELRKRIQGQTTHTFEDLNSSAKVSSDYFSQEEMLKFKKPKKKKQLRKKDKLDLSMLEAEAVASGLGAEDLGSRKDGRRQAMKEEKERIEYEKRSNAYQEAIAKADEASRLLRREQVQPFKRDEDESMVLADDAEDLYKSLEKARRLALIKKEEAGSGPQAVAHLVASSTNQTTDDNTTTGDETQENTVVFTEMGDFVWGLQRENDVRKPESEDVFMEEDVAPKAPVEVKEEHPDGLTEVNDTDMDAAEDSSDTKEITPDENIHEVAVGKGLSGALKLLKDRGTLKEKVEWGGRNMDKKKSKLVGIVDDDGGKESKDKESKDRFKDIRIERTDEFGRTLTPKEAFRLLSHKFHGKGPGKMKEEKRMKQYQEELKLKQMKNSDTPSQSVQRMREAQAQLKTPYLVLSGHVKPGQTSDPQSGFATVEKDVPGSLTPMLGDRKVEHFLGIKRKSEPGNSDTPPKRPKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	IREERADYEGSPVRE HHHHHCCCCCCCCCC		23776212
22	Phosphorylation	ERADYEGSPVREHRD HHCCCCCCCCCCCCC		19880383
383	Phosphorylation	SAKVSSDYFSQEEML CCCCCCCCCCHHHHH		25561503
385	Phosphorylation	KVSSDYFSQEEMLKF CCCCCCCCHHHHHHC		25561503
464	Phosphorylation	IAKADEASRLLRREQ HHHHHHHHHHHHHHH		24894044
598	Phosphorylation	GLTEVNDTDMDAAED CCEECCCCCCHHCCC		30407730
606	Phosphorylation	DMDAAEDSSDTKEIT CCHHCCCCCCCCCCC		27545962
607	Phosphorylation	MDAAEDSSDTKEITP CHHCCCCCCCCCCCC		30407730
609	Phosphorylation	AAEDSSDTKEITPDE HCCCCCCCCCCCCCC		30407730
687	Phosphorylation	KDIRIERTDEFGRTL HHHEEEEECCCCCCC		19880383
695	Phosphorylation	DEFGRTLTPKEAFRL CCCCCCCCHHHHHHH		19880383
755	Phosphorylation	EAQAQLKTPYLVLSG HHHHHCCCCEEEEEC		23172892
757	Phosphorylation	QAQLKTPYLVLSGHV HHHCCCCEEEEECCC		23172892
761	Phosphorylation	KTPYLVLSGHVKPGQ CCCEEEEECCCCCCC		23172892
769	Phosphorylation	GHVKPGQTSDPQSGF CCCCCCCCCCCCCCC		23172892
770	Phosphorylation	HVKPGQTSDPQSGFA CCCCCCCCCCCCCCC		23172892
774	Phosphorylation	GQTSDPQSGFATVEK CCCCCCCCCCCEEEE		23172892
778	Phosphorylation	DPQSGFATVEKDVPG CCCCCCCEEEECCCC		23172892
786	Phosphorylation	VEKDVPGSLTPMLGD EEECCCCCCCCCCCC		23172892
788	Phosphorylation	KDVPGSLTPMLGDRK ECCCCCCCCCCCCCC		30291188
806	Phosphorylation	FLGIKRKSEPGNSDT HHCCCCCCCCCCCCC		23776212
811	Phosphorylation	RKSEPGNSDTPPKRP CCCCCCCCCCCCCCC		23776212
813	Phosphorylation	SEPGNSDTPPKRPKP CCCCCCCCCCCCCCC		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOT2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOT2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOT2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of DOT2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.