DOPR1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOPR1_DROME
• UniProt AC: P41596
• Protein Name: Dopamine receptor 1
• Gene Name: Dop1R1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 511
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role in restoring dopamine homeostasis..
• Protein Sequence: MYTPHPFGFLIILVPMTNAMRAIAAIAAGVGSVAATVATSTTSSISSSTTIINTSSATTIGGNHTSGSTGFSTNSTLLDADHLPLQLTTAKVDLDIEIDIQLLTNGYDGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNPWCCAQDVGNIHPRNSDRFITDYAAKNVVVMNSGRSSAELEQVSAI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	N-linked_Glycosylation	SSSTTIINTSSATTI CCCCEEEECCCCCEE	30.02	-
63	N-linked_Glycosylation	SATTIGGNHTSGSTG CCCEECCCCCCCCCC	30.01	-
74	N-linked_Glycosylation	GSTGFSTNSTLLDAD CCCCCCCCCEEECCC	31.62	-
117	N-linked_Glycosylation	TTLTSFYNESSWTNA CEEEEECCCCCCCCH	40.43	-
123	N-linked_Glycosylation	YNESSWTNASEMDTI CCCCCCCCHHHCCCC	34.90	-
468	S-palmitoylation	LTMRNPWCCAQDVGN HHHCCCCEECCCCCC	1.13	-
469	S-palmitoylation	TMRNPWCCAQDVGNI HHCCCCEECCCCCCC	3.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOPR1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOPR1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOPR1_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of DOPR1_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.