DOP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOP2_HUMAN
• UniProt AC: Q9Y3R5
• Protein Name: Protein dopey-2
• Gene Name: DOPEY2
• Organism: Homo sapiens (Human).
• Sequence Length: 2298
• Protein Description: May be involved in protein traffic between late Golgi and early endosomes..
• Protein Sequence: MDPEEQELLNDYRYRSYSSVIEKALRNFESSSEWADLISSLGKLNKALQSNLRYSLLPRRLLISKRLAQCLHPALPSGVHLKALETYEIIFKIVGTKWLAKDLFLYSCGLFPLLAHAAVSVRPVLLTLYEKYFLPLQKLLLPSLQAFIVGLLPGLEEGSEISDRTDALLLRLSLVVGKEVFYTALWGSVLASPSIRLPASVFVVGHINRDAPGREQKYMLGTNHQLTVKSLRASLLDSNVLVQRNNLEIVLFFFPFYTCLDSNERAIPLLRSDIVRILSAATQTLLRRDMSLNRRLYAWLLGSDIKGNTVVPESEISNSYEDQSSYFFEKYSKDLLVEGLAEILHQKFIDADVEERHHAYLKPFRVLISLLDKPEIGPQVVGNLFLEVIRAFYSYCRDALGSDLKLSYTQSGNSLISAIKENRNASEIVKTVNLLITSLSTDFLWDYMTRCFEECFRPVKQRYSVRNSVSPPPTVSELCALLVFLLDVIPLELYSEVQTQYLPQVLGCLVQPLAEDMEALSLPELTHALKTCFKVLSKVQMPPSYLDTESTSGTSSPVKGENGKIILETKAVIPGDEDASFPPLKSEDSGIGLSASSPELSEHLRVPRVSLERDDVWKKGGSMQRTFLCIQELIANFASKNIFGVQLTASGEESKSEEPAGKRDRDGTQSLAANDSSRKNSWEPKPITVPQFKQMLSDLFTARGSPFKTKSSESPSSSPSSPARKNGGEWDVEKVVIDLGGSREERREAFAAACHLLLDCATFPVYLSEEETEQLCATLFQLPGAGDSSFPSWLKSLMTICCCVTDCYLQNVAISTLLEVINHSQSLALVIEDKMKRYKSSGHNPFFGKLQMVTVPPIAPGILKVIAEKTDFYQRVARVLWNQLNKETREHHVTCVELFYRLHCLAPTANICEDIICHALLDPDKGTRLEALFRFSVIWHLTREIQGSRVTSHNRSFDRSLFVVLDSLACTDGAIGAAAQGWLVRALSLGDVARILEPVLLLLLQPKTQRTSIHCLKQENSADDLHRWFNRKKTSFREACAVPEPQESGSEEHLPLSQFTTVDREAIWAEVEKEPEKYPLRGELSEEELPYYVELPDRTAHGAPDSSEHTESADTSSCHTDSENTSSFSSPSHDLQELSNEENCCAPIPMGGRAYPKRSALLAAFQSESFKAGAKLSLVRVDSDKTQASESFSSDEEADLELQALTTSRLLKQQRERQEAVEALFKHILLYLQPYDSRRVLYAFSVLEAVLKTNPKEFIEAVSRTSMDTSSTAHLNLISNLLARHQEALIGQSFYGKLQTQVPNVCPHSLLLELLTYLCLSFLRSYYPCYLKVSHRDILGNRDVQVKSVEVLIRIMMQLVSVAKSSEGKNVEFIHSLLQRCKVQEFVLLSLSASMYTSQKRYGLATAHHGRALPEDSLFEESLINLGQDQIWSEHPLQIELLKLLQVLIVLEHHLGRAHEEAENQPDLSREWQRALNFQQAISALQYVQPHPLTSQGLLVSAVVRGLQPAYGYGMHPAWVSLVTHSLPYFGKSLGWTVTPFVVQICKNLDDLVKQYESESVKLSVSTTSKRENISPDYPLTLLEGLTTISHFCLLEQANQNKKTMAAGDPANLRNARNAILEELPRTVNTMALLWNVLRKEETQKRPVDLLGATKGSSSVYFKTTKTIRQKILDFLNPLTAHLGVQLTAAVAAVWSRKKAQRHSKMKIIPTASASQLTLVDLVCALSTLQTDTLLHLVKEVVKRPPQVKGGDEKSPLVDIPVLQFCYAFLQRLPVPALQENFSSLLGVLKESVQLNLAPPGYFLLLSMLNDFVTRTPNLENKKDQKDLQEITQKILEAVGNIAGSSLEQTSWLSRNLEVKAQPQASLEESDAEEDLYDAAAASAMVSSSAPSVYSVQALSLLAEVLASLLDMVYRSDEKEKAVPLISRLLYYVFPYLRNHSAYNAPSFRAGAQLLSSLSGYAYTKRAWRKEVLELFLDPAFFQMDTSCVHWKSIIDHLLTHEKTMFKDLMNMQSSSLKLFSSFEQKAMLLKRQAFAVFSGELDQYHLYLPLIQERLTDNLRVGQTSIVAAQMFLFFRVLLLRISPQHLTSLWPIMVSELIQTFTQLEEDLKDEDESLRSTNKVNRTKVSVPDANGPSVGEIPQSELILYLSACKFLDTALSFPPDKMPLFQIYRWAFIPEVDTEGPAFLSDVEENHQECKPHTVRILELLKLKFGEISSSDEITMKSEFPLLRQHSVSSIRQLMPFFMTLNGAFKTQRQLPADSPGTPFLDFPVTDSPRILKQLEECIEYDFLEHPEC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	ELLNDYRYRSYSSVI HHHHHHHHHCHHHHH	9.55	23312004
16	Phosphorylation	LNDYRYRSYSSVIEK HHHHHHHCHHHHHHH	22.04	23312004
17	Phosphorylation	NDYRYRSYSSVIEKA HHHHHHCHHHHHHHH	8.93	27642862
18	Phosphorylation	DYRYRSYSSVIEKAL HHHHHCHHHHHHHHH	21.26	23312004
19	Phosphorylation	YRYRSYSSVIEKALR HHHHCHHHHHHHHHH	20.91	23312004
23	Ubiquitination	SYSSVIEKALRNFES CHHHHHHHHHHCCCC	41.41	21890473
23 (in isoform 1)	Ubiquitination	-	41.41	21890473
23 (in isoform 2)	Ubiquitination	-	41.41	21890473
43	Ubiquitination	DLISSLGKLNKALQS HHHHHHHHHHHHHHH	54.93	-
46	Ubiquitination	SSLGKLNKALQSNLR HHHHHHHHHHHHHCC	61.99	-
65	Ubiquitination	PRRLLISKRLAQCLH HHHHHHHHHHHHHHC	44.42	-
77	Phosphorylation	CLHPALPSGVHLKAL HHCCCCCCCCCHHHH	55.06	22210691
86	Phosphorylation	VHLKALETYEIIFKI CCHHHHHHHHHHHHH	27.57	22210691
87	Phosphorylation	HLKALETYEIIFKIV CHHHHHHHHHHHHHH	8.85	22210691
96	Phosphorylation	IIFKIVGTKWLAKDL HHHHHHCCHHHHHHH	14.25	22210691
127	Phosphorylation	SVRPVLLTLYEKYFL HHHHHHHHHHHHHCH	24.11	24260401
202	Ubiquitination	IRLPASVFVVGHINR CCCCCEEEEEEECCC	3.23	21890473
218	Phosphorylation	APGREQKYMLGTNHQ CCCCCCEECCCCCCC	9.40	-
222	Phosphorylation	EQKYMLGTNHQLTVK CCEECCCCCCCHHHH	26.09	22210691
227	Phosphorylation	LGTNHQLTVKSLRAS CCCCCCHHHHHHHHH	21.22	22210691
234	Phosphorylation	TVKSLRASLLDSNVL HHHHHHHHHCCCCEE	24.03	-
284	Phosphorylation	ILSAATQTLLRRDMS HHHHHHHHHHHHCCC	24.33	-
314	Phosphorylation	GNTVVPESEISNSYE CCEECCHHHCCCCCC	33.87	30576142
317	Phosphorylation	VVPESEISNSYEDQS ECCHHHCCCCCCCHH	18.70	26657352
319	Phosphorylation	PESEISNSYEDQSSY CHHHCCCCCCCHHHH	24.10	27251275
320	Phosphorylation	ESEISNSYEDQSSYF HHHCCCCCCCHHHHH	27.98	30576142
326	Phosphorylation	SYEDQSSYFFEKYSK CCCCHHHHHHHHHCH	19.96	30576142
330	Ubiquitination	QSSYFFEKYSKDLLV HHHHHHHHHCHHHHH	50.06	29967540
331	Phosphorylation	SSYFFEKYSKDLLVE HHHHHHHHCHHHHHH	17.47	30576142
409	Phosphorylation	SDLKLSYTQSGNSLI CCCEEEEECCCCHHH	16.94	26657352
411	Phosphorylation	LKLSYTQSGNSLISA CEEEEECCCCHHHHH	31.94	28348404
414	Phosphorylation	SYTQSGNSLISAIKE EEECCCCHHHHHHHH	30.52	28348404
420	Ubiquitination	NSLISAIKENRNASE CHHHHHHHHCCCHHH	48.96	22817900
420 (in isoform 1)	Ubiquitination	-	48.96	21890473
420 (in isoform 2)	Ubiquitination	-	48.96	21890473
460	Ubiquitination	EECFRPVKQRYSVRN HHHCCCHHHHCCCCC	31.57	-
538	Ubiquitination	TCFKVLSKVQMPPSY HHHHHHHHCCCCHHH	32.12	29967540
544	Phosphorylation	SKVQMPPSYLDTEST HHCCCCHHHCCCCCC	32.24	25247763
545	Phosphorylation	KVQMPPSYLDTESTS HCCCCHHHCCCCCCC	17.86	25247763
548	Phosphorylation	MPPSYLDTESTSGTS CCHHHCCCCCCCCCC	29.28	22199227
550	Phosphorylation	PSYLDTESTSGTSSP HHHCCCCCCCCCCCC	29.93	22199227
551	Phosphorylation	SYLDTESTSGTSSPV HHCCCCCCCCCCCCC	25.58	22199227
552	Phosphorylation	YLDTESTSGTSSPVK HCCCCCCCCCCCCCC	49.72	25849741
554	Phosphorylation	DTESTSGTSSPVKGE CCCCCCCCCCCCCCC	26.29	22199227
555	Phosphorylation	TESTSGTSSPVKGEN CCCCCCCCCCCCCCC	35.85	26657352
556	Phosphorylation	ESTSGTSSPVKGENG CCCCCCCCCCCCCCC	33.28	25849741
564	Acetylation	PVKGENGKIILETKA CCCCCCCCEEEEEEE	37.85	11923001
570	Acetylation	GKIILETKAVIPGDE CCEEEEEEEECCCCC	31.14	11923013
580	Phosphorylation	IPGDEDASFPPLKSE CCCCCCCCCCCCCCC	51.08	27251275
585	Ubiquitination	DASFPPLKSEDSGIG CCCCCCCCCCCCCCC	58.53	29967540
586	Phosphorylation	ASFPPLKSEDSGIGL CCCCCCCCCCCCCCC	55.08	28450419
589	Phosphorylation	PPLKSEDSGIGLSAS CCCCCCCCCCCCCCC	28.40	26657352
594	Phosphorylation	EDSGIGLSASSPELS CCCCCCCCCCCHHHH	22.38	29255136
596	Phosphorylation	SGIGLSASSPELSEH CCCCCCCCCHHHHHH	42.95	30266825
597	Phosphorylation	GIGLSASSPELSEHL CCCCCCCCHHHHHHC	23.31	30266825
601	Phosphorylation	SASSPELSEHLRVPR CCCCHHHHHHCCCCC	22.70	30266825
610	Phosphorylation	HLRVPRVSLERDDVW HCCCCCCCCCCCCHH	26.28	25159151
648	Phosphorylation	NIFGVQLTASGEESK CEEEEEEEECCCCCC	11.16	29514088
650	Phosphorylation	FGVQLTASGEESKSE EEEEEEECCCCCCCC	41.31	26657352
654	Phosphorylation	LTASGEESKSEEPAG EEECCCCCCCCCCCC	36.86	29514088
656	Phosphorylation	ASGEESKSEEPAGKR ECCCCCCCCCCCCCC	57.37	26699800
681	Phosphorylation	NDSSRKNSWEPKPIT CCCCCCCCCCCCCCC	35.53	22617229
688	Phosphorylation	SWEPKPITVPQFKQM CCCCCCCCHHHHHHH	34.36	28111955
693	Methylation	PITVPQFKQMLSDLF CCCHHHHHHHHHHHH	29.56	-
697	Phosphorylation	PQFKQMLSDLFTARG HHHHHHHHHHHHHCC	27.25	24719451
701	Phosphorylation	QMLSDLFTARGSPFK HHHHHHHHHCCCCCC	23.81	27251275
705	Phosphorylation	DLFTARGSPFKTKSS HHHHHCCCCCCCCCC	22.93	22199227
709	Phosphorylation	ARGSPFKTKSSESPS HCCCCCCCCCCCCCC	36.22	23898821
710	Ubiquitination	RGSPFKTKSSESPSS CCCCCCCCCCCCCCC	53.20	-
711	Phosphorylation	GSPFKTKSSESPSSS CCCCCCCCCCCCCCC	44.57	28450419
712	Phosphorylation	SPFKTKSSESPSSSP CCCCCCCCCCCCCCC	43.58	25849741
714	Phosphorylation	FKTKSSESPSSSPSS CCCCCCCCCCCCCCC	31.84	30278072
716	Phosphorylation	TKSSESPSSSPSSPA CCCCCCCCCCCCCCC	53.37	30278072
717	Phosphorylation	KSSESPSSSPSSPAR CCCCCCCCCCCCCCC	50.05	25159151
718	Phosphorylation	SSESPSSSPSSPARK CCCCCCCCCCCCCCC	32.89	25159151
720	Phosphorylation	ESPSSSPSSPARKNG CCCCCCCCCCCCCCC	51.40	25159151
721	Phosphorylation	SPSSSPSSPARKNGG CCCCCCCCCCCCCCC	26.43	25159151
849	Ubiquitination	GHNPFFGKLQMVTVP CCCCCCCEEEEEECC	30.32	-
936	Phosphorylation	LEALFRFSVIWHLTR HHHHHHHHHHHHHHH	14.40	22817900
948	Phosphorylation	LTREIQGSRVTSHNR HHHHHCCCCCCCCCC	13.75	-
951	Phosphorylation	EIQGSRVTSHNRSFD HHCCCCCCCCCCCCC	24.14	28787133
952	Phosphorylation	IQGSRVTSHNRSFDR HCCCCCCCCCCCCCH	18.86	-
956	Phosphorylation	RVTSHNRSFDRSLFV CCCCCCCCCCHHHHH	36.49	-
1007	Ubiquitination	LLLLLQPKTQRTSIH HHHHHCCCCCCCCCH	44.31	-
1021	Phosphorylation	HCLKQENSADDLHRW HHHCCCCCHHHHHHH	32.11	22985185
1034	Phosphorylation	RWFNRKKTSFREACA HHHHCCCCCHHHHCC	35.81	27251275
1035	Phosphorylation	WFNRKKTSFREACAV HHHCCCCCHHHHCCC	31.05	27251275
1048	Phosphorylation	AVPEPQESGSEEHLP CCCCCCCCCCCCCCC	42.23	27050516
1050	Phosphorylation	PEPQESGSEEHLPLS CCCCCCCCCCCCCHH	49.44	26657352
1057	Phosphorylation	SEEHLPLSQFTTVDR CCCCCCHHHCEECCH	22.70	23312004
1060	Phosphorylation	HLPLSQFTTVDREAI CCCHHHCEECCHHHH	20.48	23312004
1061	Phosphorylation	LPLSQFTTVDREAIW CCHHHCEECCHHHHH	23.00	23312004
1085	Phosphorylation	YPLRGELSEEELPYY CCCCCCCCHHHCCEE	38.36	26657352
1091	Phosphorylation	LSEEELPYYVELPDR CCHHHCCEEEECCCC	32.54	28796482
1092	Phosphorylation	SEEELPYYVELPDRT CHHHCCEEEECCCCC	5.87	28796482
1159	Phosphorylation	GRAYPKRSALLAAFQ CCCCCCHHHHHHHHH	29.42	28348404
1167	Phosphorylation	ALLAAFQSESFKAGA HHHHHHHCCCCCCCC	28.84	25850435
1169	Phosphorylation	LAAFQSESFKAGAKL HHHHHCCCCCCCCEE	36.98	25850435
1175	Acetylation	ESFKAGAKLSLVRVD CCCCCCCEEEEEEEC	37.38	25953088
1175	Ubiquitination	ESFKAGAKLSLVRVD CCCCCCCEEEEEEEC	37.38	-
1177	Phosphorylation	FKAGAKLSLVRVDSD CCCCCEEEEEEECCC	24.90	23312004
1183	Phosphorylation	LSLVRVDSDKTQASE EEEEEECCCCCCCCC	37.84	25849741
1186	Phosphorylation	VRVDSDKTQASESFS EEECCCCCCCCCCCC	34.07	28450419
1189	Phosphorylation	DSDKTQASESFSSDE CCCCCCCCCCCCCCC	24.77	28450419
1191	Phosphorylation	DKTQASESFSSDEEA CCCCCCCCCCCCCHH	28.12	30576142
1193	Phosphorylation	TQASESFSSDEEADL CCCCCCCCCCCHHHH	46.27	26657352
1194	Phosphorylation	QASESFSSDEEADLE CCCCCCCCCCHHHHH	47.21	26657352
1263	Phosphorylation	KEFIEAVSRTSMDTS HHHHHHHHCCCCCCC	36.57	-
1293	Phosphorylation	QEALIGQSFYGKLQT HHHHHCHHHHHHHHC	18.41	28442448
1295	Phosphorylation	ALIGQSFYGKLQTQV HHHCHHHHHHHHCCC	20.71	28152594
1330	Phosphorylation	LRSYYPCYLKVSHRD HHHHCCCEEEECCHH	12.68	-
1361	Phosphorylation	RIMMQLVSVAKSSEG HHHHHHHHHHHCCCC	25.58	22210691
1365	Phosphorylation	QLVSVAKSSEGKNVE HHHHHHHCCCCCCHH	24.72	22210691
1366	Phosphorylation	LVSVAKSSEGKNVEF HHHHHHCCCCCCHHH	50.06	22210691
1392	Phosphorylation	EFVLLSLSASMYTSQ HHHHHHHHHHHHHCC	18.21	24719451
1394	Phosphorylation	VLLSLSASMYTSQKR HHHHHHHHHHHCCCH	14.67	24719451
1570	Ubiquitination	LSVSTTSKRENISPD EEEECCCCCCCCCCC	62.73	29967540
1645	Acetylation	LRKEETQKRPVDLLG HCCHHHCCCCCCCCC	67.12	7960625
1645	Ubiquitination	LRKEETQKRPVDLLG HCCHHHCCCCCCCCC	67.12	29967540
1655	Acetylation	VDLLGATKGSSSVYF CCCCCCCCCCCCEEE	57.15	7960637
1657	Phosphorylation	LLGATKGSSSVYFKT CCCCCCCCCCEEEEC	22.46	29759185
1658	Phosphorylation	LGATKGSSSVYFKTT CCCCCCCCCEEEECC	32.27	29759185
1659	Phosphorylation	GATKGSSSVYFKTTK CCCCCCCCEEEECCH	23.64	29759185
1661	Phosphorylation	TKGSSSVYFKTTKTI CCCCCCEEEECCHHH	10.99	29759185
1664	Phosphorylation	SSSVYFKTTKTIRQK CCCEEEECCHHHHHH	24.51	-
1665	Phosphorylation	SSVYFKTTKTIRQKI CCEEEECCHHHHHHH	27.12	-
1816	Phosphorylation	LNDFVTRTPNLENKK HHHHHHCCCCCCCCC	13.73	29396449
1870	Phosphorylation	PQASLEESDAEEDLY CCCCCCCCCHHHHHH	32.52	26657352
1932	Phosphorylation	LISRLLYYVFPYLRN HHHHHHHHHHHHHCC	8.79	-
1965	Ubiquitination	LSGYAYTKRAWRKEV HCCCCHHHHHHHHHH	27.69	-
2014	Phosphorylation	KDLMNMQSSSLKLFS HHHHHCCCHHHHHHH	15.89	29978859
2015	Phosphorylation	DLMNMQSSSLKLFSS HHHHCCCHHHHHHHH	23.85	29978859
2016	Phosphorylation	LMNMQSSSLKLFSSF HHHCCCHHHHHHHHH	34.47	29978859
2021	Phosphorylation	SSSLKLFSSFEQKAM CHHHHHHHHHHHHHH	44.55	28509920
2022	Phosphorylation	SSLKLFSSFEQKAML HHHHHHHHHHHHHHH	26.01	28509920
2065	Phosphorylation	DNLRVGQTSIVAAQM CCCCCCCHHHHHHHH	17.94	24719451
2066	Phosphorylation	NLRVGQTSIVAAQMF CCCCCCHHHHHHHHH	13.74	28555341
2161	Phosphorylation	KFLDTALSFPPDKMP HHHHHHHCCCCCCCC	32.99	-
2218	Phosphorylation	KLKFGEISSSDEITM HCHHCCCCCCCCCCC	21.35	24719451
2219	Phosphorylation	LKFGEISSSDEITMK CHHCCCCCCCCCCCC	47.68	28348404
2220	Phosphorylation	KFGEISSSDEITMKS HHCCCCCCCCCCCCC	32.26	28348404
2264	Phosphorylation	QRQLPADSPGTPFLD CCCCCCCCCCCCCCC	27.60	24719451
2267	Phosphorylation	LPADSPGTPFLDFPV CCCCCCCCCCCCCCC	17.79	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOP2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DOP2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-936, AND MASSSPECTROMETRY.
PubMed: 18187866

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1658, AND MASSSPECTROMETRY.
PubMed: 17924679