DOP1_HUMAN - dbPTM
DOP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DOP1_HUMAN
UniProt AC Q5JWR5
Protein Name Protein dopey-1
Gene Name DOPEY1
Organism Homo sapiens (Human).
Sequence Length 2465
Subcellular Localization
Protein Description May be involved in protein traffic between late Golgi and early endosomes..
Protein Sequence MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKKLTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMSVKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSAFYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSVLVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGAIIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISLLDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIKTANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLLDIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKILSKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSESGFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQGTATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSKWDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLETDCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQPLSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQLHNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLFIMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYWNKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLSLLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMPKESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDSIQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKSRQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQTSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSRTLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIPVDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTELAKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFSEDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPHQPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVVSVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTTQYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTINLGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLVELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDSWASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGAIAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTLLSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGYQYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSSLNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQVFLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYTGGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRRQGIHQREFKPYVVRLAKLLRKRAKKNPEEDNSGRTLGWEPGHLLLTICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHKPCSSKARQKIEEMVEKDFLEGMIKT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MNTEELELLS
-----CCHHHHHHHC		42.57-
13UbiquitinationLELLSDSKYRNYVAA
HHHHCCHHHHHHHHH		53.90-
14PhosphorylationELLSDSKYRNYVAAI
HHHCCHHHHHHHHHH		14.1930576142
23UbiquitinationNYVAAIDKALKNFEY
HHHHHHHHHHHCCCC		49.89-
46UbiquitinationSALGKLNKVLQNNAK
HHHHHHHHHHHCCCC		55.55-
53UbiquitinationKVLQNNAKYQVVPKK
HHHHCCCCCCCCCCC		38.04-
62PhosphorylationQVVPKKLTIGKRLAQ
CCCCCCCCHHHHHHH		36.2423312004
82AcetylationLPGGVHRKALETYEI
CCCCHHHHHHHHHHH		42.3190515
120PhosphorylationLLANAAMSVKPTLLS
HHHHHHHCCCHHHHH		23.4324719451
129PhosphorylationKPTLLSLYEIYYLPL
CHHHHHHHEEEECCC		9.2626657352
132PhosphorylationLLSLYEIYYLPLGKT
HHHHHEEEECCCCCC		6.2426657352
201PhosphorylationAVRLPGITYVLAHLN
HHHCCCHHHHHHHHC		17.3123403867
202PhosphorylationVRLPGITYVLAHLNR
HHCCCHHHHHHHHCC		7.4923403867
233PhosphorylationLMVEAVSTSVQDSSV
HHHHHHHCCCCCCCH		26.73-
400UbiquitinationQTEPPFSKDHAQLSS
CCCCCCCHHHHHHHH		54.64-
408UbiquitinationDHAQLSSKLRENKKT
HHHHHHHHHHHCHHH		48.46-
484PhosphorylationDFLLDIVSLPTRSMR
HHHHHHHCCCCHHHH		29.0324719451
515PhosphorylationQLLLRMISALTSHLQ
HHHHHHHHHHHHHHH		14.1024043423
518PhosphorylationLRMISALTSHLQTLH
HHHHHHHHHHHHHCC		17.5124043423
519PhosphorylationRMISALTSHLQTLHL
HHHHHHHHHHHHCCH		24.0524043423
523PhosphorylationALTSHLQTLHLSELT
HHHHHHHHCCHHHHH		23.6224043423
527PhosphorylationHLQTLHLSELTDSLR
HHHHCCHHHHHHHHH		21.5824043423
530PhosphorylationTLHLSELTDSLRLCS
HCCHHHHHHHHHHHH		21.3524043423
532PhosphorylationHLSELTDSLRLCSKI
CHHHHHHHHHHHHHH		15.3424043423
565PhosphorylationFPSGQNNSVKEWEDK
CCCCCCCCCCEECCC		41.96-
668O-linked_GlycosylationTATRSRKTAQKTAMQ
CCCCCHHHHHHHHHH		32.9630379171
720UbiquitinationREQGETSKWDRNSQG
CCCCCCCCCCCCCCC		61.61-
725PhosphorylationTSKWDRNSQGDVKEK
CCCCCCCCCCCCCCC		36.1127251275
1023PhosphorylationAERYWNKSPCYPGEE
HHHHCCCCCCCCCCC		19.5925159151
1094PhosphorylationETIPMVVSDFDLPDQ
CCCCEEECCCCCCHH		22.58-
1143PhosphorylationDSQMPKESSPDDDVQ
HCCCCCCCCCCCHHH		53.9826657352
1144PhosphorylationSQMPKESSPDDDVQQ
CCCCCCCCCCCHHHH		33.1824719451
1168PhosphorylationVSGLEVESASVTSQL
HCCCEEEECCEEEEE		30.9024719451
1172PhosphorylationEVESASVTSQLEIEA
EEEECCEEEEEEEEE		14.3024719451
1236PhosphorylationANGISRNSSSPCISG
CCCCCCCCCCCCCCC		30.9628450419
1237PhosphorylationNGISRNSSSPCISGT
CCCCCCCCCCCCCCC		41.6823401153
1238PhosphorylationGISRNSSSPCISGTT
CCCCCCCCCCCCCCC		24.5028450419
1242PhosphorylationNSSSPCISGTTHTLH
CCCCCCCCCCCCCCC		36.4829978859
1244PhosphorylationSSPCISGTTHTLHDS
CCCCCCCCCCCCCCC		14.4929978859
1245PhosphorylationSPCISGTTHTLHDSS
CCCCCCCCCCCCCCC		19.1829978859
1247PhosphorylationCISGTTHTLHDSSVA
CCCCCCCCCCCCCEE		24.5623312004
1251PhosphorylationTTHTLHDSSVASIET
CCCCCCCCCEEECEE		18.9023312004
1252PhosphorylationTHTLHDSSVASIETK
CCCCCCCCEEECEEC		27.9730576142
1255PhosphorylationLHDSSVASIETKSRQ
CCCCCEEECEECCCC		20.8530576142
1258PhosphorylationSSVASIETKSRQRSH
CCEEECEECCCCCCC		32.4223312004
1264PhosphorylationETKSRQRSHSSIQFS
EECCCCCCCCCEEEE		21.2729496963
1266PhosphorylationKSRQRSHSSIQFSFK
CCCCCCCCCEEEEHH		30.3127273156
1267PhosphorylationSRQRSHSSIQFSFKE
CCCCCCCCEEEEHHH		18.2630108239
1271PhosphorylationSHSSIQFSFKEKLSE
CCCCEEEEHHHHHHH		21.0223312004
1281PhosphorylationEKLSEKVSEKETIVK
HHHHHHCCCCHHHHH		54.7629514088
1285PhosphorylationEKVSEKETIVKESGK
HHCCCCHHHHHHCCC		41.98-
1313PhosphorylationKDDDKKKSSNEKLKQ
CCCCCCCCCHHHHHH		47.4724702127
1314PhosphorylationDDDKKKSSNEKLKQT
CCCCCCCCHHHHHHH		58.8624702127
1429PhosphorylationLLARHRISVMGKDFY
HHHHCCCEECCCCCH		13.1523403867
1443PhosphorylationYSHIPVDSNHNFRSS
HHCCCCCCCCCCCHH		39.9825332170
1458PhosphorylationMYIEILISLCLYYMR
HHHHHHHHHHHHHHH		15.0223403867
1462PhosphorylationILISLCLYYMRSHYP
HHHHHHHHHHHHCCC		8.3323403867
1463PhosphorylationLISLCLYYMRSHYPT
HHHHHHHHHHHCCCC		3.5123403867
1506PhosphorylationELAKVIESSAKGFPS
HHHHHHHHHHCCCHH		25.1928857561
1507PhosphorylationLAKVIESSAKGFPSF
HHHHHHHHHCCCHHH		22.6228857561
1513PhosphorylationSSAKGFPSFISDMLS
HHHCCCHHHHHHHHH		32.71-
1534PhosphorylationVILHCLLSSIFSAQK
HHHHHHHHHHHHHHH		14.4029978859
1535PhosphorylationILHCLLSSIFSAQKW
HHHHHHHHHHHHHHH		27.8529978859
1538PhosphorylationCLLSSIFSAQKWHSE
HHHHHHHHHHHHHHH		28.2829978859
1544PhosphorylationFSAQKWHSEKMAGKN
HHHHHHHHHHHCCCC		37.4829978859
1699PhosphorylationNLIQQYKYETGLSDS
HHHHHHHHHCCCCCC		17.5017924679
1704PhosphorylationYKYETGLSDSRPLWM
HHHHCCCCCCCCCCH		34.5817924679
1759PhosphorylationKHLFEARSGILSILH
HHHHHHHHHHHHHHH		36.9124275569
1789PhosphorylationADSSEKMTIAASASL
CCCCCCCEEEEECCC		20.6624260401
1797PhosphorylationIAASASLTTINLGAT
EEEECCCEEECCCCC		24.1224260401
1798PhosphorylationAASASLTTINLGATK
EEECCCEEECCCCCC		17.1124260401
1804PhosphorylationTTINLGATKNLRQQI
EEECCCCCCCHHHHH		20.7624260401
1842PhosphorylationNERRQNKTTTRTKVI
HHHCCCCCCCCCEEE		40.7329083192
1843PhosphorylationERRQNKTTTRTKVIP
HHCCCCCCCCCEEEC		18.8529083192
1844PhosphorylationRRQNKTTTRTKVIPA
HCCCCCCCCCEEECC		41.3929083192
1999UbiquitinationLRRNLEVKPSPKIMV
HHHCCCCCCCCCEEE		30.33-
2001PhosphorylationRNLEVKPSPKIMVDG
HCCCCCCCCCEEECC		32.8625159151
2009PhosphorylationPKIMVDGTNLESDVE
CCEEECCCCCCCHHH		31.97-
2095PhosphorylationRACVQLLSSLSGYQY
HHHHHHHHHHCCCHH		37.5129759185
2096PhosphorylationACVQLLSSLSGYQYT
HHHHHHHHHCCCHHH		26.9029759185
2100PhosphorylationLLSSLSGYQYTRRAW
HHHHHCCCHHHHHHH		8.5829759185
2102PhosphorylationSSLSGYQYTRRAWKK
HHHCCCHHHHHHHHH		8.1729759185
2160PhosphorylationVAVAQSSSLNLFANR
HHHHHCCCCCHHHCC		26.90-
2386PhosphorylationEPGHLLLTICTVRSM
CCCHHHHHHHHHCCH		17.6125690035
2389PhosphorylationHLLLTICTVRSMEQL
HHHHHHHHHCCHHHH		18.3325690035
2419PhosphorylationTSRCGGHSGSPILYS
CCCCCCCCCCCCEEC		44.2126657352
2421PhosphorylationRCGGHSGSPILYSNA
CCCCCCCCCCEECCC		16.2826657352
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DOP1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DOP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DOP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DOP1_HUMAN !!
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DOP1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1699 AND SER-1704, ANDMASS SPECTROMETRY.

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