DOK6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOK6_HUMAN
• UniProt AC: Q6PKX4
• Protein Name: Docking protein 6
• Gene Name: DOK6
• Organism: Homo sapiens (Human).
• Sequence Length: 331
• Protein Description: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance..
• Protein Sequence: MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQNSVGEIYSLQGHGFGSSKMSRAQTFPSYAPEQSEEAQQPLSRSSSYGFSYSSSLIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Methylation	AYFRNFHKVTELHNI HHHCCHHHHHHHHCC	46.87	23644510
165	Phosphorylation	QITHENIYLWDIHNA EEECCCEEEEEEECC	17.20	22817900
182	Phosphorylation	KLVMWPLSSLRRYGR EEEEEEHHHHHHHCC	24.21	30301811
183	Phosphorylation	LVMWPLSSLRRYGRD EEEEEHHHHHHHCCC	33.31	25954137
220	Phosphorylation	TREGEMIYQKVHSAT ECCCEEEEHHHHHHH	10.85	22817900
249	Phosphorylation	EQKARLQTSLTEPMT HHHHHHCCCCCCCCC	30.23	-
250	Phosphorylation	QKARLQTSLTEPMTL HHHHHCCCCCCCCCC	21.97	24114839
262	Phosphorylation	MTLSKSISLPRSAYW CCCCCCCCCCCHHHH	39.14	24719451
277	Phosphorylation	HHITRQNSVGEIYSL HHHCCCCCCEEEEEE	24.14	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOK6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOK6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOK6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RET_HUMAN	RET	physical	15286081

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.