dbPTM

DNER_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DNER_HUMAN
UniProt AC	Q8NFT8
Protein Name	Delta and Notch-like epidermal growth factor-related receptor
Gene Name	DNER
Organism	Homo sapiens (Human).
Sequence Length	737
Subcellular Localization	Cell membrane Single-pass type I membrane protein. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity)..
Protein Description	Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity)..
Protein Sequence	MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVSPIAYEDYSPDDKPLVTLIKTKDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
169	O-linked_Glycosylation	PDKILPRSQATVTLP CCCCCCCCCCEEEEC	23.40	55833877
172	O-linked_Glycosylation	ILPRSQATVTLPTWQ CCCCCCCEEEECCCC	13.34	55833883
174	O-linked_Glycosylation	PRSQATVTLPTWQPK CCCCCEEEECCCCCC	23.75	55833889
177	O-linked_Glycosylation	QATVTLPTWQPKTGQ CCEEEECCCCCCCCC	39.58	55833895
223	N-linked_Glycosylation	VSFEVPQNTSVKIRQ EEEECCCCCCEEEEC	28.40	16740002
564	N-linked_Glycosylation	TCDSDGLNGTCICAP EECCCCCCCEEEECC	49.62	UniProtKB CARBOHYD
677	Phosphorylation	QGSSRPAYEEFYNCR CCCCCCCHHHHHCCC	20.76	22817900
681	Phosphorylation	RPAYEEFYNCRSIDS CCCHHHHHCCCCCCH	19.34	27259358
685	Phosphorylation	EEFYNCRSIDSEFSN HHHHCCCCCCHHHHH	32.71	22199227
688	Phosphorylation	YNCRSIDSEFSNAIA HCCCCCCHHHHHHHH	38.58	22199227
691	Phosphorylation	RSIDSEFSNAIASIR CCCCHHHHHHHHHHH	22.69	21712546
696	Phosphorylation	EFSNAIASIRHARFG HHHHHHHHHHHHHCC	17.65	22199227
706	Phosphorylation	HARFGKKSRPAMYDV HHHCCCCCCCCEEEC	47.16	26356563
711	Phosphorylation	KKSRPAMYDVSPIAY CCCCCCEEECCCCCC	18.46	27259358
714	Phosphorylation	RPAMYDVSPIAYEDY CCCEEECCCCCCCCC	14.00	25159151
718	Phosphorylation	YDVSPIAYEDYSPDD EECCCCCCCCCCCCC	15.28	22199227
721	Phosphorylation	SPIAYEDYSPDDKPL CCCCCCCCCCCCCCC	15.34	27259358
722	Phosphorylation	PIAYEDYSPDDKPLV CCCCCCCCCCCCCCE	33.89	22199227
726	Ubiquitination	EDYSPDDKPLVTLIK CCCCCCCCCCEEEEE	47.86	29967540
730	Phosphorylation	PDDKPLVTLIKTKDL CCCCCCEEEEECCCC	30.37	26356563
733	Ubiquitination	KPLVTLIKTKDL--- CCCEEEEECCCC---	53.27	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DNER_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DNER_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DNER_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DNER_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DNER_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Identification of N-linked glycoproteins in human saliva byglycoprotein capture and mass spectrometry."; Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T.,Loo J.A.; J. Proteome Res. 5:1493-1503(2006). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-223, AND MASSSPECTROMETRY.	16740002 [Abstract]