DNAS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNAS1_HUMAN
• UniProt AC: P24855
• Protein Name: Deoxyribonuclease-1
• Gene Name: DNASE1 {ECO:0000312|HGNC:HGNC:2956}
• Organism: Homo sapiens (Human).
• Sequence Length: 282
• Subcellular Localization: Secreted . Nucleus envelope. Secretory protein, stored in zymogen granules and found in the nuclear envelope.
• Protein Description: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. [PubMed: 2251263]
• Protein Sequence: MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36 (in isoform 2)	Phosphorylation	-	32.21	22210691
39	Phosphorylation	TFGETKMSNATLVSY CCCCCCCCHHHHHHH	25.52	19835603
40	N-linked_Glycosylation	FGETKMSNATLVSYI CCCCCCCHHHHHHHH	33.18	2277032
40 (in isoform 2)	Phosphorylation	-	33.18	22210691
42	Phosphorylation	ETKMSNATLVSYIVQ CCCCCHHHHHHHHHH	31.76	19835603
46	Phosphorylation	SNATLVSYIVQILSR CHHHHHHHHHHHHHH	9.53	19835603
52	Phosphorylation	SYIVQILSRYDIALV HHHHHHHHHCCCHHH	30.35	19835603
52 (in isoform 2)	Phosphorylation	-	30.35	22210691
128	N-linked_Glycosylation	DGCEPCGNDTFNREP CCCCCCCCCCCCCCH	52.44	UniProtKB CARBOHYD
211	Phosphorylation	SSIRLWTSPTFQWLI CEEEEEECCCEEEEC	15.45	30576142
224	Phosphorylation	LIPDSADTTATPTHC ECCCCCCCCCCCCCH	20.32	30576142
229	Phosphorylation	ADTTATPTHCAYDRI CCCCCCCCCHHHHHH	25.82	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNAS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNAS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNAS1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DNAS1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 152700: Systemic lupus erythematosus (SLE)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.