dbPTM

DNAI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DNAI1_HUMAN
UniProt AC	Q9UI46
Protein Name	Dynein intermediate chain 1, axonemal
Gene Name	DNAI1
Organism	Homo sapiens (Human).
Sequence Length	699
Subcellular Localization	Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium .
Protein Description	Part of the dynein complex of respiratory cilia..
Protein Sequence	MIPASAKAPHKQPHKQSISIGRGTRKRDEDSGTEVGEGTDEWAQSKATVRPPDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQLAVHYTQVGNLIPKDSDEGRRQHYRDELVAGSQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTPKQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEKQEKTKEKEKAKTPVAKKSGKMAMRKLTSMESQTDDLIKLSQAAKIMERMVNQNTYDDIAQDFKYYDDAADEYRDQVGTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQSRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRGHIISLKLSPNLRKMPKEKKGQEVQKGPAVEIAKLDKLLNLVREVKIKT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	TRKRDEDSGTEVGEG CCCCCCCCCCCCCCC	45.63	30622161
33	Phosphorylation	KRDEDSGTEVGEGTD CCCCCCCCCCCCCCC	31.30	30622161
71	Phosphorylation	EEFTRILTANNPHAP HHHHHHHHCCCCCCC	25.60	-
131	Phosphorylation	RDELVAGSQESVKVI HHHHHCCCHHHEEEE	22.49	22817900
134	Phosphorylation	LVAGSQESVKVISET HHCCCHHHEEEEECC	21.43	14702039
139	Phosphorylation	QESVKVISETGNLEE HHHEEEEECCCCCCC	31.90	30622161
141	Phosphorylation	SVKVISETGNLEEDE HEEEEECCCCCCCCC	25.28	30622161
155	Phosphorylation	EEPKELETEPGSQTD CCCCCCCCCCCCCCC	61.17	30622161
159	Phosphorylation	ELETEPGSQTDVPAA CCCCCCCCCCCCCCC	40.39	30622161
161	Phosphorylation	ETEPGSQTDVPAAGA CCCCCCCCCCCCCCC	40.43	30622161
179	Phosphorylation	VTEEELMTPKQPKER CCHHHHCCCCCCCCC	39.70	27251275
219	Phosphorylation	QTEPPPRTNFSATAN CCCCCCCCCCCCCCC	46.52	22468782
222	Phosphorylation	PPPRTNFSATANQWE CCCCCCCCCCCCCHH	27.12	22468782
295	Phosphorylation	RMVNQNTYDDIAQDF HHCCCCCHHHHHHHC	21.11	-
304	Phosphorylation	DIAQDFKYYDDAADE HHHHHCCCCHHHHHH	16.48	-
312	Phosphorylation	YDDAADEYRDQVGTL CHHHHHHHHHHHHHH	21.75	-
334	Phosphorylation	NDKAKRLSVTALCWN CCCCCCEEEEEEEEC	22.81	22964224
336	Phosphorylation	KAKRLSVTALCWNPK CCCCEEEEEEEECHH	15.55	25693802
343	Acetylation	TALCWNPKYRDLFAV EEEEECHHHHHHEEE	50.10	25038526
354	Phosphorylation	LFAVGYGSYDFMKQS HEEECCCCHHHHHHC	17.03	27762562
355	Phosphorylation	FAVGYGSYDFMKQSR EEECCCCHHHHHHCC	14.61	28509920
361	Phosphorylation	SYDFMKQSRGMLLLY CHHHHHHCCCEEEEE	25.86	28509920
368	Phosphorylation	SRGMLLLYSLKNPSF CCCEEEEEECCCCCC	16.36	28674151
369	Phosphorylation	RGMLLLYSLKNPSFP CCEEEEEECCCCCCC	32.60	24719451
561	Phosphorylation	KVFMSCSSDWTVKIW EEEEECCCCEEEEEE	41.30	28509920
564	Phosphorylation	MSCSSDWTVKIWDHT EECCCCEEEEEEECE	19.53	28509920
616	Acetylation	IFDLAINKYEAICNQ EEEEEECHHHHHHCC	38.05	25038526
655	Phosphorylation	DDRGHIISLKLSPNL CCCCCEEEEEECHHH	20.88	24719451
687	Acetylation	VEIAKLDKLLNLVRE HHHHHHHHHHHHHHH	66.37	25038526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DNAI1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DNAI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DNAI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SQSTM_HUMAN	SQSTM1	physical	25015291

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
244400	Ciliary dyskinesia, primary, 1 (CILD1)
244400	Kartagener syndrome (KTGS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DNAI1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of capacitated human sperm. Evidence oftyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation."; Ficarro S., Chertihin O., Westbrook V.A., White F., Jayes F.,Kalab P., Marto J.A., Shabanowitz J., Herr J.C., Hunt D.F.,Visconti P.E.; J. Biol. Chem. 278:11579-11589(2003). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131 AND SER-134, ANDMASS SPECTROMETRY.	12509440 [Abstract]