| UniProt ID | DMRT2_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y5R5 | |
| Protein Name | Doublesex- and mab-3-related transcription factor 2 | |
| Gene Name | DMRT2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 561 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity).. | |
| Protein Sequence | MADPQAGSAAGDWEIDVESLELEEDVCGAPRSTPPGPSPPPADGDCEDDEDDDGVDEDAEEEGDGEEAGASPGMPGQPEQRGGPQPRPPLAPQASPAGTGPRERCTPAGGGAEPRKLSRTPKCARCRNHGVVSCLKGHKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQATEDKKGLSGKQNNFERKAVYQRQVRAPSLLAKSILEGYRPIPAETYVGGTFPLPPPVSDRMRKRRAFADKELENIMLEREYKEREMLETSQAAALFLPNRMVPGPDYNSYKSAYSPSPVEPPSKDFCNFLPTCLDLTMQYSGSGNMELISSNVSVATTYRQYPLSSRFLVWPKCGPISDTLLYQQCLLNATTSVQALKPGASWDLKGARVQDGLSAEQDMMPSKLEGSLVLPHTPEIQTTRSDLQGHQAVPERSAFSPPRRNFSPIVDTDSLAAQGHVLTKISKENTRHPLPLRHNPFHSLFQQTLTDKSGPELKTPFVKEAFEETPKKHRECLVKDNQKYTFTIDRCAKDLFVAKQVGTKLSVNEPLSFSVESILKRPSSAITRVSQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 95 | Phosphorylation | PPLAPQASPAGTGPR CCCCCCCCCCCCCCC | 15.27 | 24961811 | |
| 332 | Phosphorylation | NVSVATTYRQYPLSS CEEEEEEECCCCCCC | 7.43 | - | |
| 338 | Phosphorylation | TYRQYPLSSRFLVWP EECCCCCCCCEEECC | 18.24 | - | |
| 339 | Phosphorylation | YRQYPLSSRFLVWPK ECCCCCCCCEEECCC | 34.43 | - | |
| 356 | Phosphorylation | PISDTLLYQQCLLNA CCCHHHHHHHHHHCC | 10.31 | 22817900 | |
| 366 | Phosphorylation | CLLNATTSVQALKPG HHHCCCCCCHHCCCC | 14.10 | - | |
| 375 | Phosphorylation | QALKPGASWDLKGAR HHCCCCCCCCCCCCC | 27.34 | - | |
| 415 | Phosphorylation | PEIQTTRSDLQGHQA CCCCCCHHHHCCCCC | 40.35 | - | |
| 427 | Phosphorylation | HQAVPERSAFSPPRR CCCCCCCCCCCCCCC | 31.81 | - | |
| 430 | Phosphorylation | VPERSAFSPPRRNFS CCCCCCCCCCCCCCC | 33.44 | 24719451 | |
| 514 | Phosphorylation | LVKDNQKYTFTIDRC EECCCCEEEEEEEHH | 9.42 | - | |
| 547 | Phosphorylation | PLSFSVESILKRPSS CCCCCHHHHHCCCHH | 30.94 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DMRT2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DMRT2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DMRT2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of DMRT2_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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