dbPTM

DMBX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DMBX1_HUMAN
UniProt AC	Q8NFW5
Protein Name	Diencephalon/mesencephalon homeobox protein 1
Gene Name	DMBX1 {ECO:0000312\|HGNC:HGNC:19026}
Organism	Homo sapiens (Human).
Sequence Length	382
Subcellular Localization	Nucleus .
Protein Description	Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity)..
Protein Sequence	MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLAGCTFQDIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGSDPPAELHLSLSEQSASESAPEDQPDREEDPRAGAEDPKAEKSPGADSKGLGCKRGSPKADSPGSLTITPVAPGGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAAAVPYLGVNMAPLGSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPAGLAPASATLNSKTTSIENLRLRAKQHAASLGLDTLPN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	O-linked_Glycosylation	RPSVHALTLAERLAG CCHHHHHHHHHHHCC	25.38	30379171
95	Phosphorylation	KTFQKTHYPDVVMRE HHHHHHCCCCHHHHH	13.32	18669648
142	Acetylation	KEQLQKQKEAEGSHG HHHHHHHHHHCCCCC	66.96	11925863
221	Ubiquitination	KSPGADSKGLGCKRG CCCCCCCCCCCCCCC	59.72	-
229	Phosphorylation	GLGCKRGSPKADSPG CCCCCCCCCCCCCCC	27.53	-
262	Phosphorylation	SYSSSPLSLFRLQEQ CCCCCCHHHHHHHHH	28.92	24719451
360	Phosphorylation	TLNSKTTSIENLRLR CCCCCCCCHHHHHHH	32.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DMBX1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DMBX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DMBX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DMBX1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DMBX1_HUMAN

Related Literatures of Post-Translational Modification