DLG3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DLG3_RAT
• UniProt AC: Q62936
• Protein Name: Disks large homolog 3
• Gene Name: Dlg3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 849
• Protein Description: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling..
• Protein Sequence: MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPSGGNGASSGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKNTPKLNGSGPSWWPECTCTNRDWYEQASPAPLLVNPEALEPSLSVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVTYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNLKGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIFDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	CCKCPECYEVTRLAA CCCCCCHHHHHHHHH	16.27	-
157	Phosphorylation	IVLERGNSGLGFSIA EEEECCCCCCCCEEE	37.91	-
286	Ubiquitination	IEGGAAQKDGRLQIG EECCCCCCCCCCEEC	58.38	-
324	Phosphorylation	KNTSDMVYLKVAKPG CCCCCCEEEEECCCC	8.31	-
383	Phosphorylation	APPQVPPTRYSPIPR CCCCCCCCCCCCCCH	35.85	28432305
386	Phosphorylation	QVPPTRYSPIPRHML CCCCCCCCCCCHHHC	17.05	28432305
505	Phosphorylation	LREQMMNSSMSSGSG HHHHHHHCCCCCCCC	14.99	27097102
506	Phosphorylation	REQMMNSSMSSGSGS HHHHHHCCCCCCCCC	20.06	27097102
508	Phosphorylation	QMMNSSMSSGSGSLR HHHHCCCCCCCCCCC	33.23	27097102
509	Phosphorylation	MMNSSMSSGSGSLRT HHHCCCCCCCCCCCC	28.47	27097102
511	Phosphorylation	NSSMSSGSGSLRTSE HCCCCCCCCCCCCHH	27.44	27097102
513	Phosphorylation	SMSSGSGSLRTSEKR CCCCCCCCCCCHHCC	19.17	27097102
533	Phosphorylation	ALFDYDRTRDSCLPS HHCCCCCCCCCCCCC	35.61	25403869
557	Phosphorylation	ILHVINASDDEWWQA EEEEEECCCCCCEEE	40.90	22673903
602	Phosphorylation	TVKFHARTGMIESNR HHHHHHHCCCCCCCC	31.70	16641100
615	Phosphorylation	NRDFPGLSDDYYGAK CCCCCCCCCCCCCCC	34.06	-
618	Phosphorylation	FPGLSDDYYGAKNLK CCCCCCCCCCCCCCC	14.59	-
619	Phosphorylation	PGLSDDYYGAKNLKG CCCCCCCCCCCCCCC	20.01	-
631	Phosphorylation	LKGVTSNTSDSESSS CCCCCCCCCCCCCCC	33.41	25403869
632	Phosphorylation	KGVTSNTSDSESSSK CCCCCCCCCCCCCCC	43.31	27115346
638	Phosphorylation	TSDSESSSKGQEDAI CCCCCCCCCCCCCEE	50.51	28689409
683	Acetylation	LISEFPHKFGSCVPH HHHHCCCCCCCCCCC	52.22	22902405
705	Phosphorylation	NEVDGQDYHFVVSRE CCCCCCEEEEEEEHH	6.83	21940666

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
632	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
632	S	Phosphorylation	Kinase	CK2B	P67870	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DLG3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DLG3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of DLG3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.