DLDH1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DLDH1_ARATH
• UniProt AC: Q9M5K3
• Protein Name: Dihydrolipoyl dehydrogenase 1, mitochondrial
• Gene Name: LPD1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 507
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Lipoamide dehydrogenase is a component of the glycine decarboxylase (GDC) or glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. LPD1 is probably the protein most often associated with the glycine decarboxylase complex while LPD2 is probably incorporated into alpha-ketoacid dehydrogenase complexes..
• Protein Sequence: MAMASLARRKAYFLTRNLSNSPTDALRFSFSLSRGFASSGSDENDVVIIGGGPGGYVAAIKASQLGLKTTCIEKRGALGGTCLNVGCIPSKALLHSSHMYHEAKHSFANHGIKVSSVEVDLPAMLAQKDNAVKNLTRGIEGLFKKNKVTYVKGYGKFISPNEVSVETIDGGNTIVKGKHIIVATGSDVKSLPGITIDEKKIVSSTGALSLSEVPKKLIVIGAGYIGLEMGSVWGRLGSEVTVVEFAGDIVPSMDGEIRKQFQRSLEKQKMKFMLKTKVVSVDSSSDGVKLTVEPAEGGEQSILEADVVLVSAGRTPFTSGLDLEKIGVETDKAGRILVNDRFLSNVPGVYAIGDVIPGPMLAHKAEEDGVACVEFIAGKHGHVDYDKVPGVVYTHPEVASVGKTEEQLKKEGVSYRVGKFPFMANSRAKAIDNAEGLVKILADKETDKILGVHIMAPNAGELIHEAVLAINYDASSEDIARVCHAHPTMSEALKEAAMATYDKPIHI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
190	Phosphorylation	ATGSDVKSLPGITID EECCCCCCCCCCEEC	39.38	30291188
211	Phosphorylation	STGALSLSEVPKKLI CCCCCCHHHCCCEEE	32.92	29654922
315	Phosphorylation	VLVSAGRTPFTSGLD EEEECCCCCCCCCCC	23.10	23776212
318	Phosphorylation	SAGRTPFTSGLDLEK ECCCCCCCCCCCHHH	24.08	23776212
319	Phosphorylation	AGRTPFTSGLDLEKI CCCCCCCCCCCHHHH	37.42	23776212
423	Sulfoxidation	RVGKFPFMANSRAKA EECCCCCCCCCHHHH	3.34	25693801
426	Phosphorylation	KFPFMANSRAKAIDN CCCCCCCCHHHHCCC	24.87	24243849

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DLDH1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DLDH1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DLDH1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of DLDH1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.