DJC27_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DJC27_HUMAN
• UniProt AC: Q9NZQ0
• Protein Name: DnaJ homolog subfamily C member 27
• Gene Name: DNAJC27
• Organism: Homo sapiens (Human).
• Sequence Length: 273
• Subcellular Localization: Nucleus .
• Protein Description: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling..
• Protein Sequence: MEANMPKRKEPGRSLRIKVISMGNAEVGKSCIIKRYCEKRFVSKYLATIGIDYGVTKVHVRDREIKVNIFDMAGHPFFYEVRNEFYKDTQGVILVYDVGQKDSFDALDAWLAEMKQELGPHGNMENIIFVVCANKIDCTKHRCVDESEGRLWAESKGFLYFETSAQTGEGINEMFQTFYISIVDLCENGGKRPTTNSSASFTKEQADAIRRIRNSKDSWDMLGVKPGASRDEVNKAYRKLAVLLHPDKCVAPGSEDAFKAVVNARTALLKNIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	SLRIKVISMGNAEVG CEEEEEEEECCCCCC	24.51	-
30	Phosphorylation	GNAEVGKSCIIKRYC CCCCCCCCHHHHHHH	12.48	-
96	Phosphorylation	TQGVILVYDVGQKDS CCEEEEEEECCCCCC	11.06	-
200	Phosphorylation	PTTNSSASFTKEQAD CCCCCCCCCCHHHHH	35.08	24719451
237	Phosphorylation	RDEVNKAYRKLAVLL HHHHHHHHHHHHHHH	15.19	20049867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DJC27_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DJC27_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DJC27_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DJC27_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.