DIP2C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DIP2C_HUMAN
• UniProt AC: Q9Y2E4
• Protein Name: Disco-interacting protein 2 homolog C
• Gene Name: DIP2C
• Organism: Homo sapiens (Human).
• Sequence Length: 1556
• Protein Sequence: MADRSLEGMALPLEVRARLAELELELSEGDITQKGYEKKRSKLIGAYLPQPPRVDQALPQERRAPVTPSSASRYHRRRSSGSRDERYRSDVHTEAVQAALAKHKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINMEHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVMAQTHIENHSAPPDVTTYTSEHSIQVERPQGSTGSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREFFVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKAPCLTTMDTNGKPLYILTYGKLWTRSMKVAYSILHKLGTKQEPMVRPGDRVALVFPNNDPAAFMAAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLPKSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVLGVTVTRTALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIPYSLMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGANPWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHGLTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEIGELCVCAVATGTSYYGLSGMTKNTFEVFPMTSSGAPISEYPFIRTGLLGFVGPGGLVFVVGKMDGLMVVSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFLSEVLQWRAQTTPDHILYTLLNCRGAIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQLICKLLRSREAAAAVDVRTWPLILDTDDLPKKRPAQICKPCNPDTLAYLDFSVSTTGMLAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILIPPSELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTIWARTGYLGFLRRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MADRSLEGMALP ---CCCCCCCCCCCC	31.18	29255136
27	Phosphorylation	AELELELSEGDITQK HHHEEEECCCCCCCC	30.11	-
32	Phosphorylation	ELSEGDITQKGYEKK EECCCCCCCCCHHHH	29.03	-
47	Phosphorylation	RSKLIGAYLPQPPRV HHHCCCEECCCCCCH	17.44	27642862
67	Phosphorylation	QERRAPVTPSSASRY HHHCCCCCCCHHHHH	19.18	22199227
69	Phosphorylation	RRAPVTPSSASRYHR HCCCCCCCHHHHHHH	29.21	22199227
70	Phosphorylation	RAPVTPSSASRYHRR CCCCCCCHHHHHHHC	31.31	22199227
72	Phosphorylation	PVTPSSASRYHRRRS CCCCCHHHHHHHCCC	35.01	22199227
87	Phosphorylation	SGSRDERYRSDVHTE CCCCCHHHHHHHHHH	16.66	30266825
89	Phosphorylation	SRDERYRSDVHTEAV CCCHHHHHHHHHHHH	34.74	30266825
93	Phosphorylation	RYRSDVHTEAVQAAL HHHHHHHHHHHHHHH	26.03	30266825
114	Phosphorylation	KMAVPMPSKRRSLVV CCCCCCCCCCCEEEE	32.32	23532336
213	Phosphorylation	APPDVTTYTSEHSIQ CCCCCCEEEECCEEE	10.02	22817900
244	Phosphorylation	GNAELMETGDGVPVS CCEEEEECCCCCCCH	26.97	-
251	Phosphorylation	TGDGVPVSSRVSAKI CCCCCCCHHHHHHHH	13.32	-
252	Phosphorylation	GDGVPVSSRVSAKIQ CCCCCCHHHHHHHHH	36.61	-
257	Ubiquitination	VSSRVSAKIQQLVNT CHHHHHHHHHHHHHH	33.28	21890473
264	Phosphorylation	KIQQLVNTLKRPKRP HHHHHHHHHCCCCCC	26.61	29255136
331	Phosphorylation	LQRWGTISPKAPCLT HHHHCCCCCCCCEEE	21.86	24719451
357	Phosphorylation	LTYGKLWTRSMKVAY EEECHHHHHHHHHHH	24.25	29449344
359	Phosphorylation	YGKLWTRSMKVAYSI ECHHHHHHHHHHHHH	18.64	23186163
364	Phosphorylation	TRSMKVAYSILHKLG HHHHHHHHHHHHHHC	10.14	23186163
365	Phosphorylation	RSMKVAYSILHKLGT HHHHHHHHHHHHHCC	14.67	23186163
452	Phosphorylation	CHKGLPKSPTGEIPQ HCCCCCCCCCCCCCC	26.25	25850435
454	Phosphorylation	KGLPKSPTGEIPQFK CCCCCCCCCCCCCCC	55.31	25850435
555	Phosphorylation	LWHGILTSVMNMMHV HHHHHHHHHHHHHHH	18.87	19835603
567	Phosphorylation	MHVISIPYSLMKVNP HHHHHHCHHHCCCCC	16.87	19835603
576	Phosphorylation	LMKVNPLSWIQKVCQ HCCCCCCHHHHHHHH	24.32	-
612	Phosphorylation	DQRDINLSSLRMLIV CCCCCCHHHEEEEEE	23.88	30301811
613	Phosphorylation	QRDINLSSLRMLIVA CCCCCHHHEEEEEEC	24.14	25954137
868	Phosphorylation	RVLQAIDSIHQVGVY HHHHHHHHHHHHCCE	18.83	22673903
875	Phosphorylation	SIHQVGVYCLALVPA HHHHHCCEEEEEEEC	3.94	22673903
884	Phosphorylation	LALVPANTLPKTPLG EEEEECCCCCCCCCC	46.69	22673903
888	Phosphorylation	PANTLPKTPLGGIHL ECCCCCCCCCCCEEE	23.08	22673903
896	Phosphorylation	PLGGIHLSETKQLFL CCCCEEEHHHCHHHH	29.11	22673903
898	Phosphorylation	GGIHLSETKQLFLEG CCEEEHHHCHHHHCC	22.25	22673903
945	Phosphorylation	VMVGNLVSGKRIAQA EEEEHHHCCCCHHHC	41.59	-
982	Phosphorylation	VLQWRAQTTPDHILY HHHHHHHCCCHHHHH	39.03	27251275
983	Phosphorylation	LQWRAQTTPDHILYT HHHHHHCCCHHHHHH	18.03	27251275
990	Phosphorylation	TPDHILYTLLNCRGA CCHHHHHHHHHCCHH	22.71	27251275
1171	Phosphorylation	IKLQCELYPSREVAI HHCEEEECCCCCEEE	4.11	25690035
1232	Phosphorylation	KVRDTFCSYSVMELC HHHCCCCCHHHHHHH	19.09	30576142
1233	Phosphorylation	VRDTFCSYSVMELCT HHCCCCCHHHHHHHH	13.38	30576142
1240	Phosphorylation	YSVMELCTKGLGSQT HHHHHHHHCCCCCCH	40.55	30576142
1245	Phosphorylation	LCTKGLGSQTESLKA HHHCCCCCCHHHHHH	38.68	30576142
1251	Ubiquitination	GSQTESLKARGLDLS CCCHHHHHHCCCCHH	45.37	21890473
1258	Phosphorylation	KARGLDLSRVRTCVV HHCCCCHHHCEEEEE	28.53	-
1278	Phosphorylation	PRIALTQSFSKLFKD CCEEEHHHHHHHHHH	26.67	24719451
1281	Ubiquitination	ALTQSFSKLFKDLGL EEHHHHHHHHHHCCC	56.80	21890473
1337	Phosphorylation	VRLVERGSPHSLPLM EEEHHCCCCCCCCCC	26.17	23403867
1340	Phosphorylation	VERGSPHSLPLMESG HHCCCCCCCCCCCCC	34.76	23403867
1438	Phosphorylation	GERHDALYVVGALDE CCCCEEEEEEECHHH	8.53	18083107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DIP2C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DIP2C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DIP2C_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DIP2C_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.