dbPTM

DHYS_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DHYS_CAEEL
UniProt AC	Q9XXJ0
Protein Name	Deoxyhypusine synthase {ECO:0000250\|UniProtKB:P49366}
Gene Name	dhps-1 {ECO:0000312\|WormBase:Y17G7B.4}
Organism	Caenorhabditis elegans.
Sequence Length	371
Subcellular Localization
Protein Description	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function..
Protein Sequence	MSTNEAAASQEDIALAQGAVLVKSCQVPDGSIPIRGFDFSTASGPDFSLSAILSSYMSTGFQATHLAQAIQQVNQMLSLRDTPLTCDDDEKLFPYPEGRQKRSCTIFLGYTSNLVTSGLREVLRYCVQRNLVDCIVTSAGGIEEDLIKCLKPSYLGTFTMDGAKLRSNGMNRAGNVLIPNDNYCAFEDWLMPILDECLVEQEEKHLNWTPSKLIQRLGERIGDESSILYWAAKHRIPVFCPALTDGSLGDMLYFHSVKSSPGLRVDIVEDVRHINTIAVKSFKTGSIILGGGVVKHHINNANLMRNGADHTVYINTGQEFDGSDSGAQPDEAVSWGKVKPSAGAVKVHAEATLVFPLLVAETFAKHEGHKD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of DHYS_CAEEL !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DHYS_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DHYS_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DHYS_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DHYS_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DHYS_CAEEL

Related Literatures of Post-Translational Modification