DHX34_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHX34_HUMAN
• UniProt AC: Q14147
• Protein Name: Probable ATP-dependent RNA helicase DHX34
• Gene Name: DHX34
• Organism: Homo sapiens (Human).
• Sequence Length: 1143
• Protein Description: Probable ATP-binding RNA helicase..
• Protein Sequence: MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKFWTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKVLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVPDAFNSSRKDSDQIFHTQAKQGAVLHPTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPALQSLLLFSRSLDTNGDCSRLVADGWLELQLADSESAIRLLAASLRLRARWESALDRQLAHQAQQQLEEEEEDTPVSPKEVATLSKELLQFTASKIPYSLRRLTGLEVQNMYVGPQTIPATPHLPGLFGSSTLSPHPTKGGYAVTDFLTYNCLTNDTDLYSDCLRTFWTCPHCGLHAPLTPLERIAHENTCPQAPQDGPPGAEEAALETLQKTSVLQRPYHCEACGKDFLFTPTEVLRHRKQHV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	RDHHRAPSEEEALEK CCCCCCCCHHHHHHH	57.57	29255136
27	Ubiquitination	SEEEALEKWDWNCPE CHHHHHHHCCCCCHH	51.83	29967540
59	Ubiquitination	QGSEECQKFWTFFER HCHHHHHHHHHHHHH	55.30	-
115	Phosphorylation	LSVLGPATRGSQGLG EEEECCCCCCCCCCC	38.40	-
116	Methylation	SVLGPATRGSQGLGR EEECCCCCCCCCCCC	44.89	-
123	Methylation	RGSQGLGRHLPAERV CCCCCCCCCCCHHHH	32.96	-
146	Ubiquitination	HYLDFGQKQAFGRLA HHCHHCHHHHHHHHH	43.93	21963094
219	Phosphorylation	PRRIACISLAKRVGF CCHHHHHHHHHHHCC	23.35	-
241	Ubiquitination	SQVGYQIRFESTRSA CCCCCEEEECCCCCC	17.47	21963094
243	Ubiquitination	VGYQIRFESTRSAAT CCCEEEECCCCCCHH	41.15	22817900
270	Ubiquitination	QIQREPSLPQYEVLI HHHCCCCCCCEEEEE	4.48	21963094
353	Ubiquitination	EAEPTTSKSEKLDPR CCCCCCCCCCCCCCH	61.62	22817900
356	Ubiquitination	PTTSKSEKLDPRPFL CCCCCCCCCCCHHHH	66.34	22817900
368	Phosphorylation	PFLRVLESIDHKYPP HHHHHHHHCCCCCCH	29.20	22210691
460	Ubiquitination	RFVVDSGKVKEMSYD EEEEECCCCEECCCC	54.83	29967540
471	Ubiquitination	MSYDPQAKLQRLQEF CCCCHHHHHHHHHHH	39.65	-
533	Ubiquitination	DSLVLQMKSMSVGDP HHHHHHHHHCCCCCC	30.00	21963094
624	Phosphorylation	PFTRSAQSSPECAAA CCCCCCCCCHHHHHH	47.80	25262027
625	Phosphorylation	FTRSAQSSPECAAAR CCCCCCCCHHHHHHC	16.79	24719451
708	Phosphorylation	QAAQVGDSYSRLQQR HHHHHCCHHHHHHHH	21.05	28555341
749	Phosphorylation	QEEQDGGSSDEDRAG ECCCCCCCCCCCCCC	39.90	29255136
750	Phosphorylation	EEQDGGSSDEDRAGP CCCCCCCCCCCCCCC	48.58	29255136
763	Phosphorylation	GPAPPGASDGVDIQD CCCCCCCCCCCCHHH	40.59	26503892
772	Ubiquitination	GVDIQDVKFKLRHDL CCCHHHHHHHHHHHH	45.10	21963094
774	Acetylation	DIQDVKFKLRHDLAQ CHHHHHHHHHHHHHH	38.60	18529847
774	Ubiquitination	DIQDVKFKLRHDLAQ CHHHHHHHHHHHHHH	38.60	22817900
801	Ubiquitination	REQLALLKLVLGRGL HHHHHHHHHHHCCCC	37.08	21963094
823	Ubiquitination	DAFNSSRKDSDQIFH CCCCCCCCCHHHHCC	64.63	29967540
825	Phosphorylation	FNSSRKDSDQIFHTQ CCCCCCCHHHHCCCH	34.15	28634120
834	Ubiquitination	QIFHTQAKQGAVLHP HHCCCHHCCCCEECC	39.17	29967540
880	Phosphorylation	SSKHQLLSFVSLLET CHHHHHHHHHHHHHH	31.99	29978859
883	Phosphorylation	HQLLSFVSLLETNKP HHHHHHHHHHHHCCC	25.81	29978859
887	Phosphorylation	SFVSLLETNKPYLVN HHHHHHHHCCCCCHH	48.81	29978859
889	Acetylation	VSLLETNKPYLVNCV HHHHHHCCCCCHHHC	42.32	26051181
973	Phosphorylation	LEEEEEDTPVSPKEV HHHCCCCCCCCHHHH	28.95	29978859
976	Phosphorylation	EEEDTPVSPKEVATL CCCCCCCCHHHHHHH	31.30	20068231
984	Phosphorylation	PKEVATLSKELLQFT HHHHHHHCHHHHHHH	21.52	29083192
985	Ubiquitination	KEVATLSKELLQFTA HHHHHHCHHHHHHHH	56.33	29967540
991	Phosphorylation	SKELLQFTASKIPYS CHHHHHHHHHCCCHH	19.63	29083192
993	Phosphorylation	ELLQFTASKIPYSLR HHHHHHHHCCCHHHH	28.23	29083192
998	Phosphorylation	TASKIPYSLRRLTGL HHHCCCHHHHHHHCC	15.28	24719451
1131	Phosphorylation	CGKDFLFTPTEVLRH CCCCCCCCHHHHHHH	31.29	26270265
1133	Phosphorylation	KDFLFTPTEVLRHRK CCCCCCHHHHHHHHH	35.35	26270265

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHX34_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHX34_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHX34_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPOA2_HUMAN	POLA2	physical	16169070
TRM2A_HUMAN	TRMT2A	physical	22939629
EXOC8_HUMAN	EXOC8	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.