DHTK1_MOUSE - dbPTM
DHTK1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DHTK1_MOUSE
UniProt AC A2ATU0
Protein Name Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
Gene Name Dhtkd1
Organism Mus musculus (Mouse).
Sequence Length 921
Subcellular Localization Mitochondrion.
Protein Description The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)..
Protein Sequence MASAATVAAAGRALRRAVLLLRRGYQTERGVYGYRPRKAKSGEPRGDRARPSVDHGLARLVTVYCEHGHKAAQINPLFPGQALLDTVPEIQALVRTLQGPFTTTGLLNLGKEAASLEEVLAYLNHIYCGPISIETAQLQSQEERDWFARRFEELKKETFTTEERKYLSKLLLESQEFDHFLATKFATVKRYGGEGAESMMGFFHELLKLSAYGGITDIIIGMPHRGRLNLLTGLLQLPPELMFRKMRGLSEFPENVATIGDVLSHLTSSVDLDFGAHQPLHVTMLPNPSHLEAVNPVAVGKTRGRQQSREDGDYSPNGSAQPGDKVICLQVHGDASFCGQGIVLETFTLSNLPHFRIGGSIHLIVNNQLGYTTPAERGRSSLYSSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIVDLLCYRQWGHNELDEPFFTNPVMYKIIRARKSIPDTYAEHLIASGLMTQEEVSDIKTSYYTKLNDHLANVAHYSPPATNLQARWQGLVQPEACVTTWDTGVPLELLRFIGVKSVEVPEELQVHSHLLKMYVQSRMEKVKNGSGLDWATAETLALGSLLAQGFNVRLSGQDVGRGTFSQRHAMVVCQDTDDAYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPTLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGLVILLPHGYDGAGPEHSSCRIERFLQMCDSAEEGVDSDTVNMFVVHPTTPAQYFHLLRRQMIRNFRKPLIVASPKMLLRYPAAVSTLEEMAPGTAFKPVIGDSSVDPKNVKTLIFCSGKHFYALLKQRESLGTKKHDFAIIRLEELCPFPLDALQQEMSKYKHVRDVIWSQEEPQNMGPWSFVSPRFEKQLACRLRLVSRPPLPAPAVGIGTVHQQQHEDILSKTFTQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
156AcetylationRRFEELKKETFTTEE
HHHHHHHHCCCCHHH		74.7023576753
184SuccinylationFDHFLATKFATVKRY
HHHHHHHHHHHCHHH		27.65-
184SuccinylationFDHFLATKFATVKRY
HHHHHHHHHHHCHHH		27.6523806337
184AcetylationFDHFLATKFATVKRY
HHHHHHHHHHHCHHH		27.6523806337
189SuccinylationATKFATVKRYGGEGA
HHHHHHCHHHCCCCH		35.2323806337
189SuccinylationATKFATVKRYGGEGA
HHHHHHCHHHCCCCH		35.23-
189AcetylationATKFATVKRYGGEGA
HHHHHHCHHHCCCCH		35.2323806337
393S-nitrosylationDIGKLVGCAIIHVNG
HHHHHEEEEEEEECC		1.5922178444
430S-palmitoylationDVIVDLLCYRQWGHN
HHHHHHHHCCCCCCC		3.2328526873
431PhosphorylationVIVDLLCYRQWGHNE
HHHHHHHCCCCCCCC		13.0524719451
499PhosphorylationHLANVAHYSPPATNL
HHCCCCCCCCCCCCH		17.0929472430
500PhosphorylationLANVAHYSPPATNLQ
HCCCCCCCCCCCCHH		17.9729472430
504PhosphorylationAHYSPPATNLQARWQ
CCCCCCCCCHHHHHC		42.0829472430
554SuccinylationQVHSHLLKMYVQSRM
HHHHHHHHHHHHHHH		34.2524315375
554AcetylationQVHSHLLKMYVQSRM
HHHHHHHHHHHHHHH		34.2523576753
779PhosphorylationRYPAAVSTLEEMAPG
HCHHHHHHHHHHCCC		31.4327357545
787PhosphorylationLEEMAPGTAFKPVIG
HHHHCCCCCCCCCCC		28.0622817900
801GlutarylationGDSSVDPKNVKTLIF
CCCCCCCCCCCEEEE		70.6624703693
801AcetylationGDSSVDPKNVKTLIF
CCCCCCCCCCCEEEE		70.6623806337
801SuccinylationGDSSVDPKNVKTLIF
CCCCCCCCCCCEEEE		70.66-
801SuccinylationGDSSVDPKNVKTLIF
CCCCCCCCCCCEEEE		70.6623806337
804AcetylationSVDPKNVKTLIFCSG
CCCCCCCCEEEEECH		47.1923806337
804GlutarylationSVDPKNVKTLIFCSG
CCCCCCCCEEEEECH		47.1924703693
804SuccinylationSVDPKNVKTLIFCSG
CCCCCCCCEEEEECH		47.1923806337
809S-palmitoylationNVKTLIFCSGKHFYA
CCCEEEEECHHHHHH		4.0928526873
819SuccinylationKHFYALLKQRESLGT
HHHHHHHHHHHHHCC		48.4323806337
819SuccinylationKHFYALLKQRESLGT
HHHHHHHHHHHHHCC		48.43-
819GlutarylationKHFYALLKQRESLGT
HHHHHHHHHHHHHCC		48.4324703693
819AcetylationKHFYALLKQRESLGT
HHHHHHHHHHHHHCC		48.4323806337
827AcetylationQRESLGTKKHDFAII
HHHHHCCCCCCEEEE		46.446568309
828AcetylationRESLGTKKHDFAIIR
HHHHCCCCCCEEEEE		48.5222902405
828GlutarylationRESLGTKKHDFAIIR
HHHHCCCCCCEEEEE		48.5224703693
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DHTK1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DHTK1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DHTK1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DHTK1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DHTK1_MOUSE

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory