DHRS4_MOUSE - dbPTM
DHRS4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DHRS4_MOUSE
UniProt AC Q99LB2
Protein Name Dehydrogenase/reductase SDR family member 4
Gene Name Dhrs4
Organism Mus musculus (Mouse).
Sequence Length 279
Subcellular Localization Peroxisome.
Protein Description Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity)..
Protein Sequence MQKAGRLLGGWTQAWMSVRMASSGLTRRNPLSNKVALVTASTDGIGFAIARRLAEDGAHVVVSSRKQQNVDRAVATLQGEGLSVTGIVCHVGKAEDREKLITTALKRHQGIDILVSNAAVNPFFGNLMDVTEEVWDKVLSINVTATAMMIKAVVPEMEKRGGGSVVIVGSVAGFTRFPSLGPYNVSKTALLGLTKNFAAELAPKNIRVNCLAPGLIKTRFSSVLWEEKAREDFIKEAMQIRRLGKPEDCAGIVSFLCSEDASYINGETVVVGGGTPSRL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationWMSVRMASSGLTRRN
HHHHHHHCCCCCCCC		18.6527717184
23PhosphorylationMSVRMASSGLTRRNP
HHHHHHCCCCCCCCC		28.4327717184
26PhosphorylationRMASSGLTRRNPLSN
HHHCCCCCCCCCCCC		30.9827717184
32PhosphorylationLTRRNPLSNKVALVT
CCCCCCCCCCEEEEE		35.5423140645
63PhosphorylationDGAHVVVSSRKQQNV
CCCEEEEECCCHHCH		16.8923140645
64PhosphorylationGAHVVVSSRKQQNVD
CCEEEEECCCHHCHH		31.7123140645
89S-palmitoylationLSVTGIVCHVGKAED
CEEEEEEEEECCHHH		1.7126165157
89S-nitrosylationLSVTGIVCHVGKAED
CEEEEEEEEECCHHH		1.7121278135
89S-nitrosocysteineLSVTGIVCHVGKAED
CEEEEEEEEECCHHH		1.71-
93AcetylationGIVCHVGKAEDREKL
EEEEEECCHHHHHHH		47.7323576753
93SuccinylationGIVCHVGKAEDREKL
EEEEEECCHHHHHHH		47.7323806337
93SuccinylationGIVCHVGKAEDREKL
EEEEEECCHHHHHHH		47.73-
99SuccinylationGKAEDREKLITTALK
CCHHHHHHHHHHHHH		46.1924315375
99AcetylationGKAEDREKLITTALK
CCHHHHHHHHHHHHH		46.1923864654
106GlutarylationKLITTALKRHQGIDI
HHHHHHHHHCCCCCE		43.6324703693
106UbiquitinationKLITTALKRHQGIDI
HHHHHHHHHCCCCCE		43.6322790023
106MalonylationKLITTALKRHQGIDI
HHHHHHHHHCCCCCE		43.6326320211
106SuccinylationKLITTALKRHQGIDI
HHHHHHHHHCCCCCE		43.63-
106AcetylationKLITTALKRHQGIDI
HHHHHHHHHCCCCCE		43.6323576753
106UbiquitinationKLITTALKRHQGIDI
HHHHHHHHHCCCCCE		43.63-
159AcetylationAVVPEMEKRGGGSVV
HHHHHHHHCCCCEEE		55.8423864654
179PhosphorylationAGFTRFPSLGPYNVS
ECCCCCCCCCCCCCC		43.1523140645
187UbiquitinationLGPYNVSKTALLGLT
CCCCCCCHHHHHHCC		33.2722790023
187UbiquitinationLGPYNVSKTALLGLT
CCCCCCCHHHHHHCC		33.2722790023
195UbiquitinationTALLGLTKNFAAELA
HHHHHCCCCHHHHHC		55.9322790023
195UbiquitinationTALLGLTKNFAAELA
HHHHHCCCCHHHHHC		55.9322790023
204SuccinylationFAAELAPKNIRVNCL
HHHHHCCCCEEEECC		60.4426388266
204GlutarylationFAAELAPKNIRVNCL
HHHHHCCCCEEEECC		60.4424703693
204AcetylationFAAELAPKNIRVNCL
HHHHHCCCCEEEECC		60.4423864654
210S-nitrosylationPKNIRVNCLAPGLIK
CCCEEEECCCCCHHH		2.9121278135
210S-nitrosocysteinePKNIRVNCLAPGLIK
CCCEEEECCCCCHHH		2.91-
217SuccinylationCLAPGLIKTRFSSVL
CCCCCHHHHHHHHHH		38.40-
217GlutarylationCLAPGLIKTRFSSVL
CCCCCHHHHHHHHHH		38.4024703693
217AcetylationCLAPGLIKTRFSSVL
CCCCCHHHHHHHHHH		38.4023576753
217UbiquitinationCLAPGLIKTRFSSVL
CCCCCHHHHHHHHHH		38.4022790023
217UbiquitinationCLAPGLIKTRFSSVL
CCCCCHHHHHHHHHH		38.40-
217SuccinylationCLAPGLIKTRFSSVL
CCCCCHHHHHHHHHH		38.4023806337
218PhosphorylationLAPGLIKTRFSSVLW
CCCCHHHHHHHHHHC		29.9223984901
221PhosphorylationGLIKTRFSSVLWEEK
CHHHHHHHHHHCHHH		19.0822817900
222PhosphorylationLIKTRFSSVLWEEKA
HHHHHHHHHHCHHHH		20.6527180971
228SuccinylationSSVLWEEKAREDFIK
HHHHCHHHHHHHHHH		41.0323806337
228AcetylationSSVLWEEKAREDFIK
HHHHCHHHHHHHHHH		41.0323864654
228SuccinylationSSVLWEEKAREDFIK
HHHHCHHHHHHHHHH		41.03-
228GlutarylationSSVLWEEKAREDFIK
HHHHCHHHHHHHHHH		41.0324703693
235SuccinylationKAREDFIKEAMQIRR
HHHHHHHHHHHHHHH		39.1423806337
235AcetylationKAREDFIKEAMQIRR
HHHHHHHHHHHHHHH		39.1423806337
235SuccinylationKAREDFIKEAMQIRR
HHHHHHHHHHHHHHH		39.14-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DHRS4_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DHRS4_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DHRS4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DHRS4_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DHRS4_MOUSE

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Related Literatures of Post-Translational Modification

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