dbPTM

DHE3_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DHE3_RAT
UniProt AC	P10860
Protein Name	Glutamate dehydrogenase 1, mitochondrial
Gene Name	Glud1
Organism	Rattus norvegicus (Rat).
Sequence Length	558
Subcellular Localization	Mitochondrion matrix.
Protein Description	Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate..
Protein Sequence	MYRRLGEVLLLSRAGPAALGSAAADSAALLGWARGQPSAVPQPGLTPVARRHYSEAATDREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRENEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGLGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKVYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Acetylation	EDDPNFFKMVEGFFD CCCCCHHHHHHCHHH	37.59	26302492
68	Succinylation	EDDPNFFKMVEGFFD CCCCCHHHHHHCHHH	37.59	-
68	Succinylation	EDDPNFFKMVEGFFD CCCCCHHHHHHCHHH	37.59	-
79	Phosphorylation	GFFDRGASIVEDKLV CHHHCCCHHHHHHHH	29.95	29779826
84	Acetylation	GASIVEDKLVEDLKT CCHHHHHHHHHHHHC	40.71	25786129
84	Succinylation	GASIVEDKLVEDLKT CCHHHHHHHHHHHHC	40.71	-
84	Succinylation	GASIVEDKLVEDLKT CCHHHHHHHHHHHHC	40.71	-
90	Acetylation	DKLVEDLKTRENEEQ HHHHHHHHCCCCHHH	58.83	25786129
91	Phosphorylation	KLVEDLKTRENEEQK HHHHHHHCCCCHHHH	50.98	23991683
98	Acetylation	TRENEEQKRNRVRGI CCCCHHHHHHHHHHH	55.72	26302492
110	Acetylation	RGILRIIKPCNHVLS HHHHHHHHCCCEEEE	40.94	-
110	Succinylation	RGILRIIKPCNHVLS HHHHHHHHCCCEEEE	40.94	-
110	Succinylation	RGILRIIKPCNHVLS HHHHHHHHCCCEEEE	40.94	-
128	Phosphorylation	PIRRDDGSWEVIEGY EEECCCCCEEEEEEE	27.36	23991683
135	Phosphorylation	SWEVIEGYRAQHSQH CEEEEEEEECCCCCC	7.03	28689409
152	Phosphorylation	PCKGGIRYSTDVSVD CCCCCCCCCCCCCHH	17.63	23991683
153	O-linked_Glycosylation	CKGGIRYSTDVSVDE CCCCCCCCCCCCHHH	14.32	27213235
153	Phosphorylation	CKGGIRYSTDVSVDE CCCCCCCCCCCCHHH	14.32	30181290
154	Phosphorylation	KGGIRYSTDVSVDEV CCCCCCCCCCCHHHH	31.33	23991683
157	Phosphorylation	IRYSTDVSVDEVKAL CCCCCCCCHHHHHHH	27.02	23991683
162	Acetylation	DVSVDEVKALASLMT CCCHHHHHHHHHHHH	35.32	22902405
162	Succinylation	DVSVDEVKALASLMT CCCHHHHHHHHHHHH	35.32	-
162	Succinylation	DVSVDEVKALASLMT CCCHHHHHHHHHHHH	35.32	26843850
171	Acetylation	LASLMTYKCAVVDVP HHHHHHCEEEEEECC	13.42	-
172	ADP-ribosylation	ASLMTYKCAVVDVPF HHHHHCEEEEEECCC	2.15	-
172	ADP-ribosylation	ASLMTYKCAVVDVPF HHHHHCEEEEEECCC	2.15	-
183	Acetylation	DVPFGGAKAGVKINP ECCCCCCCCCCCCCC	49.28	-
183	Succinylation	DVPFGGAKAGVKINP ECCCCCCCCCCCCCC	49.28	-
183	Succinylation	DVPFGGAKAGVKINP ECCCCCCCCCCCCCC	49.28	-
187	Acetylation	GGAKAGVKINPKNYT CCCCCCCCCCCCCCC	35.53	25786129
187	Succinylation	GGAKAGVKINPKNYT CCCCCCCCCCCCCCC	35.53	26843850
191	Acetylation	AGVKINPKNYTDNEL CCCCCCCCCCCHHHH	59.09	22902405
191	Succinylation	AGVKINPKNYTDNEL CCCCCCCCCCCHHHH	59.09	-
191	Succinylation	AGVKINPKNYTDNEL CCCCCCCCCCCHHHH	59.09	26843850
193	Phosphorylation	VKINPKNYTDNELEK CCCCCCCCCHHHHHH	22.92	23991683
194	Phosphorylation	KINPKNYTDNELEKI CCCCCCCCHHHHHHH	41.56	23991683
200	Acetylation	YTDNELEKITRRFTM CCHHHHHHHHHHHHH	63.10	22902405
200	Succinylation	YTDNELEKITRRFTM CCHHHHHHHHHHHHH	63.10	-
200	Succinylation	YTDNELEKITRRFTM CCHHHHHHHHHHHHH	63.10	-
206	Phosphorylation	EKITRRFTMELAKKG HHHHHHHHHHHHHCC	14.13	22817900
211	Acetylation	RFTMELAKKGFIGPG HHHHHHHHCCCCCCC	67.08	22902405
212	Acetylation	FTMELAKKGFIGPGI HHHHHHHCCCCCCCC	54.14	55699603
212	Succinylation	FTMELAKKGFIGPGI HHHHHHHCCCCCCCC	54.14	26843850
227	Phosphorylation	DVPAPDMSTGEREMS CCCCCCCCCCHHHHH	40.41	23991683
228	O-linked_Glycosylation	VPAPDMSTGEREMSW CCCCCCCCCHHHHHH	36.10	27213235
228	Phosphorylation	VPAPDMSTGEREMSW CCCCCCCCCHHHHHH	36.10	23991683
270	Phosphorylation	GGIHGRISATGRGVF CCCCCCCCCCCCCHH	20.58	29779826
272	Phosphorylation	IHGRISATGRGVFHG CCCCCCCCCCCHHHC	22.18	30181290
316	Phosphorylation	FGNVGLHSMRYLHRF CCCCCHHHHHHHHHC	15.25	28689409
326	Acetylation	YLHRFGAKCVGVGES HHHHCCCEEEEECCC	29.81	-
333	Phosphorylation	KCVGVGESDGSIWNP EEEEECCCCCCCCCC	41.15	28689409
336	Phosphorylation	GVGESDGSIWNPDGI EECCCCCCCCCCCCC	29.44	28689409
346	"N6,N6-dimethyllysine"	NPDGIDPKELEDFKL CCCCCCHHHHHHCCC	71.79	-
346	Acetylation	NPDGIDPKELEDFKL CCCCCCHHHHHHCCC	71.79	22902405
346	Methylation	NPDGIDPKELEDFKL CCCCCCHHHHHHCCC	71.79	12692561
346	Succinylation	NPDGIDPKELEDFKL CCCCCCHHHHHHCCC	71.79	-
352	"N6,N6-dimethyllysine"	PKELEDFKLQHGSIL HHHHHHCCCCCCCCC	60.61	-
352	Acetylation	PKELEDFKLQHGSIL HHHHHHCCCCCCCCC	60.61	22902405
352	Methylation	PKELEDFKLQHGSIL HHHHHHCCCCCCCCC	60.61	12692561
352	Succinylation	PKELEDFKLQHGSIL HHHHHHCCCCCCCCC	60.61	-
357	Phosphorylation	DFKLQHGSILGFPKA HCCCCCCCCCCCCCC	16.71	23991683
363	Acetylation	GSILGFPKAKVYEGS CCCCCCCCCEEECCC	59.59	22902405
363	Succinylation	GSILGFPKAKVYEGS CCCCCCCCCEEECCC	59.59	-
363	Succinylation	GSILGFPKAKVYEGS CCCCCCCCCEEECCC	59.59	-
365	Acetylation	ILGFPKAKVYEGSIL CCCCCCCEEECCCCE	52.02	-
365	Succinylation	ILGFPKAKVYEGSIL CCCCCCCEEECCCCE	52.02	-
365	Succinylation	ILGFPKAKVYEGSIL CCCCCCCEEECCCCE	52.02	-
367	Phosphorylation	GFPKAKVYEGSILEA CCCCCEEECCCCEEE	17.54	23984901
370	Phosphorylation	KAKVYEGSILEADCD CCEEECCCCEEECCC	16.44	23991683
384	Phosphorylation	DILIPAASEKQLTKS CEEEECCCHHHCCCC	47.64	30181290
386	Acetylation	LIPAASEKQLTKSNA EEECCCHHHCCCCCC	48.38	-
390	Acetylation	ASEKQLTKSNAPRVK CCHHHCCCCCCCHHE	50.75	22902405
390	Succinylation	ASEKQLTKSNAPRVK CCHHHCCCCCCCHHE	50.75	-
390	Succinylation	ASEKQLTKSNAPRVK CCHHHCCCCCCCHHE	50.75	-
391	Phosphorylation	SEKQLTKSNAPRVKA CHHHCCCCCCCHHEE	32.75	23991683
399	Acetylation	NAPRVKAKIIAEGAN CCCHHEEEEEECCCC	29.00	22902405
409	Phosphorylation	AEGANGPTTPEADKI ECCCCCCCCHHHHHH	57.28	27097102
410	Phosphorylation	EGANGPTTPEADKIF CCCCCCCCHHHHHHH	23.43	29779826
415	Acetylation	PTTPEADKIFLERNI CCCHHHHHHHHHCCE	42.26	25786129
415	Succinylation	PTTPEADKIFLERNI CCCHHHHHHHHHCCE	42.26	-
415	Succinylation	PTTPEADKIFLERNI CCCHHHHHHHHHCCE	42.26	-
450	Phosphorylation	LKNLNHVSYGRLTFK HHCCCCCEEEEEEEE	17.83	29779826
451	Phosphorylation	KNLNHVSYGRLTFKY HCCCCCEEEEEEEEE	12.74	23991683
455	Phosphorylation	HVSYGRLTFKYERDS CCEEEEEEEEEECCC	19.40	23984901
457	N6-malonyllysine	SYGRLTFKYERDSNY EEEEEEEEEECCCCC	40.75	-
457	Acetylation	SYGRLTFKYERDSNY EEEEEEEEEECCCCC	40.75	25786129
457	Malonylation	SYGRLTFKYERDSNY EEEEEEEEEECCCCC	40.75	-
457	Succinylation	SYGRLTFKYERDSNY EEEEEEEEEECCCCC	40.75	-
469	Phosphorylation	SNYHLLMSVQESLER CCCEEEEEHHHHHHH	22.18	30181290
473	Phosphorylation	LLMSVQESLERKFGK EEEEHHHHHHHHHHC	20.59	30181290
477	Acetylation	VQESLERKFGKHGGT HHHHHHHHHHCCCCC	49.44	22902405
477	Succinylation	VQESLERKFGKHGGT HHHHHHHHHHCCCCC	49.44	-
477	Succinylation	VQESLERKFGKHGGT HHHHHHHHHHCCCCC	49.44	-
480	Acetylation	SLERKFGKHGGTIPV HHHHHHHCCCCCCCC	42.06	22902405
480	Succinylation	SLERKFGKHGGTIPV HHHHHHHCCCCCCCC	42.06	-
480	Succinylation	SLERKFGKHGGTIPV HHHHHHHCCCCCCCC	42.06	-
484	Phosphorylation	KFGKHGGTIPVVPTA HHHCCCCCCCCCCCH	27.05	23991683
490	Phosphorylation	GTIPVVPTAEFQDRI CCCCCCCCHHHHHHC	27.49	25575281
498	Phosphorylation	AEFQDRISGASEKDI HHHHHHCCCCCHHHH	29.24	28689409
501	Phosphorylation	QDRISGASEKDIVHS HHHCCCCCHHHHCHH	49.02	25575281
503	N6-malonyllysine	RISGASEKDIVHSGL HCCCCCHHHHCHHHH	50.70	-
503	Acetylation	RISGASEKDIVHSGL HCCCCCHHHHCHHHH	50.70	25786129
503	Malonylation	RISGASEKDIVHSGL HCCCCCHHHHCHHHH	50.70	-
503	Succinylation	RISGASEKDIVHSGL HCCCCCHHHHCHHHH	50.70	26843850
508	Phosphorylation	SEKDIVHSGLAYTME CHHHHCHHHHHHHHH	25.30	28689409
512	Phosphorylation	IVHSGLAYTMERSAR HCHHHHHHHHHHHHH	16.21	23991683
513	Phosphorylation	VHSGLAYTMERSARQ CHHHHHHHHHHHHHH	13.62	30181290
527	N6-malonyllysine	QIMRTAMKYNLGLDL HHHHHHHHHCCCCCH	28.64	-
527	Acetylation	QIMRTAMKYNLGLDL HHHHHHHHHCCCCCH	28.64	25786129
527	Malonylation	QIMRTAMKYNLGLDL HHHHHHHHHCCCCCH	28.64	-
527	Succinylation	QIMRTAMKYNLGLDL HHHHHHHHHCCCCCH	28.64	26843850
545	Acetylation	AYVNAIEKVFKVYNE HHHHHHHHHHHHHHH	47.02	25786129
545	Succinylation	AYVNAIEKVFKVYNE HHHHHHHHHHHHHHH	47.02	-
545	Succinylation	AYVNAIEKVFKVYNE HHHHHHHHHHHHHHH	47.02	26843850
548	Acetylation	NAIEKVFKVYNEAGV HHHHHHHHHHHHCCC	46.96	22902405
558	Phosphorylation	NEAGVTFT------- HHCCCCCC-------	28.47	28689409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
206	T	Phosphorylation	Kinase	PRKACA	P00517	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DHE3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DHE3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DHE3_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DHE3_RAT

Related Literatures of Post-Translational Modification