DESI2_HUMAN - dbPTM
DESI2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DESI2_HUMAN
UniProt AC Q9BSY9
Protein Name Deubiquitinase DESI2 {ECO:0000305}
Gene Name DESI2
Organism Homo sapiens (Human).
Sequence Length 194
Subcellular Localization Cytoplasm .
Protein Description Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization. [PubMed: 28483520]
Protein Sequence MGANQLVVLNVYDMYWMNEYTSSIGIGVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASELGETFKFKEAVVLGSTDFLEDDIEKIVEELGKEYKGNAYHLMHKNCNHFSSALSEILCGKEIPRWINRLAYFSSCIPFLQSCLPKEWLTPAALQSSVSQELQDELEEAEDAAASASVASTAAGSRPGRHTKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
47PhosphorylationFAYGGHPYPFSGIFE
ECCCCCCCCCCEEEE
15.96-
64 (in isoform 2)Ubiquitination-28.0421890473
66PhosphorylationNASELGETFKFKEAV
CHHHHCCEEEEEEEE
30.26-
87UbiquitinationFLEDDIEKIVEELGK
CCHHHHHHHHHHHHH
53.00-
97UbiquitinationEELGKEYKGNAYHLM
HHHHHHHCCCHHHHH
46.942189047
97 (in isoform 1)Ubiquitination-46.9421890473
122UbiquitinationLSEILCGKEIPRWIN
HHHHHCCCCCHHHHH
52.02-
176PhosphorylationEAEDAAASASVASTA
HHHHHHHHHHHHHHH
19.1522468782
178PhosphorylationEDAAASASVASTAAG
HHHHHHHHHHHHHCC
18.7422468782
186PhosphorylationVASTAAGSRPGRHTK
HHHHHCCCCCCCCCC
30.4922468782
193UbiquitinationSRPGRHTKL------
CCCCCCCCC------
46.18-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DESI2_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DESI2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DESI2_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DESI2_HUMAN !!

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DESI2_HUMAN

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Related Literatures of Post-Translational Modification

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