DEN5A_MOUSE - dbPTM
DEN5A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DEN5A_MOUSE
UniProt AC Q6PAL8
Protein Name DENN domain-containing protein 5A
Gene Name Dennd5a
Organism Mus musculus (Mouse).
Sequence Length 1287
Subcellular Localization Golgi apparatus membrane .
Protein Description Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (By similarity)..
Protein Sequence MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPLADGGDQSGMEDGEGIPGTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLQQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGVPPEGNLHCSESASKLKRIRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDFKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLCTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYIQEARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQENRQRKLTSGSLSTSGILLDSERRKSDASAVMSPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQILQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVECVMVRNEVTGHTYKFPCGRWLGKGMDDGSLERVLVGELLTSLPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEQNDVVPEENWHTRARNFCRFVTAVNNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNITLDTSLVKGIDI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
52PhosphorylationSKARDGASPFISSTT
HHCCCCCCCCCCCCC		26.3525338131
193PhosphorylationTKLQRFNSYDISRDT
CCCEECCCCCCCCCC		22.8226824392
194PhosphorylationKLQRFNSYDISRDTL
CCEECCCCCCCCCCC		20.5722817900
197PhosphorylationRFNSYDISRDTLYVS
ECCCCCCCCCCCHHE		22.6223984901
200PhosphorylationSYDISRDTLYVSKCI
CCCCCCCCCHHEEEE		20.9123984901
202PhosphorylationDISRDTLYVSKCICL
CCCCCCCHHEEEEHH		12.5523984901
204PhosphorylationSRDTLYVSKCICLIT
CCCCCHHEEEEHHHC		14.3023984901
455PhosphorylationRNGNIAGSPLHSYEL
CCCCCCCCCCHHHHH		18.4419060867
468PhosphorylationELLKENETIARLQAL
HHHHCCHHHHHHHHH		31.3622802335
479PhosphorylationLQALVKRTGVSLEKL
HHHHHHHHCCCHHEE		35.9029109428
557UbiquitinationEQMQNFDKASFLSDQ
HHHHCCCHHHHCCCC		41.62-
618PhosphorylationIRLLNVRTPTLRTSM
EEEECCCCCCCCHHH		19.1523608596
620PhosphorylationLLNVRTPTLRTSMYQ
EECCCCCCCCHHHHC		28.4123608596
628UbiquitinationLRTSMYQKCTTVDEA
CCHHHHCCCCCHHHH		18.9622790023
736PhosphorylationTIRQPKLSNLSPSVI
CCCCCCHHCCCHHHH		41.6829899451
739PhosphorylationQPKLSNLSPSVIAQT
CCCHHCCCHHHHHHC		21.2726643407
741PhosphorylationKLSNLSPSVIAQTNW
CHHCCCHHHHHHCCH		23.8426643407
833PhosphorylationENRQRKLTSGSLSTS
HHHCCCCCCCCCCCC		33.7922817900
834PhosphorylationNRQRKLTSGSLSTSG
HHCCCCCCCCCCCCC		36.5024759943
836PhosphorylationQRKLTSGSLSTSGIL
CCCCCCCCCCCCCEE		20.9325266776
838PhosphorylationKLTSGSLSTSGILLD
CCCCCCCCCCCEEEC		23.4029514104
840PhosphorylationTSGSLSTSGILLDSE
CCCCCCCCCEEECCC		22.0629899451
851PhosphorylationLDSERRKSDASAVMS
ECCCCCCCHHHHHCC		36.2826824392
854PhosphorylationERRKSDASAVMSPLR
CCCCCHHHHHCCHHH		26.7926643407
1067PhosphorylationVLVGELLTSLPEVDE
HHHHHHHHCCCCCCC		40.6226160508
1068PhosphorylationLVGELLTSLPEVDER
HHHHHHHCCCCCCCC		41.7326160508
1079PhosphorylationVDERPCRTPPLQQSP
CCCCCCCCCCCCCCH		35.6626824392
1085PhosphorylationRTPPLQQSPSVIRRL
CCCCCCCCHHHHHHH		13.2426824392
1087PhosphorylationPPLQQSPSVIRRLVT
CCCCCCHHHHHHHEE		35.1121082442
1094PhosphorylationSVIRRLVTISPNNKP
HHHHHHEEECCCCCC		21.9629472430
1096PhosphorylationIRRLVTISPNNKPKL
HHHHEEECCCCCCCC		16.5326824392
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DEN5A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DEN5A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DEN5A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DEN5A_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DEN5A_MOUSE

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory