DEN4B_HUMAN - dbPTM
DEN4B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DEN4B_HUMAN
UniProt AC O75064
Protein Name DENN domain-containing protein 4B
Gene Name DENND4B
Organism Homo sapiens (Human).
Sequence Length 1496
Subcellular Localization Golgi apparatus .
Protein Description Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form..
Protein Sequence MAEERPPRLVDYFVVAGLAGNGAPIPEETWVPEPSGPLRPPRPAEPITDVAVIARALGEEVPQGYTCIQASAGGHPLELSAGLLGGTQPVICYRRGRDKPPLVELGVLYEGKERPKPGFQVLDTTPYSHSANLAPPGPGHPRTYLTYRRAAEGAGLHALGITDLCLVLPSKGEGTPHTYCRLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPEQEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGFPELRAELFESLQEQPGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLPAYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVKSGSLGSARGAQPTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGGSGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARLQQLLTPSRHSPASRIPPPELPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLEILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLALDEPQLCNGHMGGASRRVESGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASCDGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAALGKDHVDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAIDCRKCFGAPPEC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationRPPRLVDYFVVAGLA
CCCCHHEEEEEECCC		7.27-
99UbiquitinationCYRRGRDKPPLVELG
EEECCCCCCCEEEEE		47.37-
127PhosphorylationQVLDTTPYSHSANLA
EEECCCCCCCCCCCC		19.54-
170PhosphorylationDLCLVLPSKGEGTPH
EEEEEECCCCCCCCC		49.4824719451
171UbiquitinationLCLVLPSKGEGTPHT
EEEEECCCCCCCCCC		60.07-
299PhosphorylationARALGLLSAVERGRA
HHHHHHHHHHHHHHH		35.0030257219
303MethylationGLLSAVERGRALGGR
HHHHHHHHHHHCCCH		33.04-
335PhosphorylationPAFRAFLTFLYRYSV
HHHHHHHHHHHHHCC		12.7324719451
338PhosphorylationRAFLTFLYRYSVSGP
HHHHHHHHHHCCCCC		11.8724719451
341PhosphorylationLTFLYRYSVSGPHRL
HHHHHHHCCCCCCCC		10.7824719451
506UbiquitinationLFQTEEKKLLSPRTL
CEECHHHHCCCCCCC		58.92-
509PhosphorylationTEEKKLLSPRTLPRR
CHHHHCCCCCCCCCC		23.8324719451
519UbiquitinationTLPRRPYKVLLATLT
CCCCCHHHHHHHHHH		29.14-
593PhosphorylationRPLTQAPSEGARDVD
ECCCCCCCCCCCCCH		52.2428555341
610UbiquitinationFFLQGFLKSRERSSH
HHHHHHHHHCHHHHH		45.25-
677PhosphorylationELEELSGSELTVFIT
EEEECCCCEEEEEEC		26.51-
680PhosphorylationELSGSELTVFITPPE
ECCCCEEEEEECCCC		14.87-
684PhosphorylationSELTVFITPPEEPAL
CEEEEEECCCCCCCC		22.71-
716PhosphorylationLRAELFESLQEQPGA
HHHHHHHHHHHCCCC		28.1926074081
730PhosphorylationALPVPGPSRSAPSSP
CCCCCCCCCCCCCCC		44.7930576142
731MethylationLPVPGPSRSAPSSPA
CCCCCCCCCCCCCCC		39.72-
732PhosphorylationPVPGPSRSAPSSPAP
CCCCCCCCCCCCCCC		49.2028176443
735PhosphorylationGPSRSAPSSPAPRRT
CCCCCCCCCCCCHHH		48.9830576142
736PhosphorylationPSRSAPSSPAPRRTK
CCCCCCCCCCCHHHH		24.8328176443
742PhosphorylationSSPAPRRTKQEMKVA
CCCCCHHHHHHHHHH		38.0626074081
755UbiquitinationVAQRMAQKSAAVPEL
HHHHHHHHHCCHHHH		32.31-
862UbiquitinationNKAVLESKWPSGTPG
CHHHHHCCCCCCCCC		54.47-
941PhosphorylationTRPLQRQTTWAGRSL
CCCCCCCCCCCCCCC		26.8827486199
942PhosphorylationRPLQRQTTWAGRSLR
CCCCCCCCCCCCCCC		12.6530576142
947PhosphorylationQTTWAGRSLRDPASP
CCCCCCCCCCCCCCC		27.1723401153
953PhosphorylationRSLRDPASPPGRLVK
CCCCCCCCCCCCEEE		36.7029255136
960UbiquitinationSPPGRLVKSGSLGSA
CCCCCEEECCCCCCC		54.41-
961PhosphorylationPPGRLVKSGSLGSAR
CCCCEEECCCCCCCC		26.5723312004
963PhosphorylationGRLVKSGSLGSARGA
CCEEECCCCCCCCCC		36.3329900121
966PhosphorylationVKSGSLGSARGAQPT
EECCCCCCCCCCCCC		21.7828102081
968MethylationSGSLGSARGAQPTVE
CCCCCCCCCCCCCHH		42.55-
993PhosphorylationGVLEPRGSPVPWHDG
CCCCCCCCCCCCCCC		24.8126074081
1001PhosphorylationPVPWHDGSLSDLSLT
CCCCCCCCHHHCCCC		30.6628857561
1003PhosphorylationPWHDGSLSDLSLTGE
CCCCCCHHHCCCCCC		37.9028348404
1066PhosphorylationARLQQLLTPSRHSPA
HHHHHHHCCCCCCCH		28.0126055452
1068PhosphorylationLQQLLTPSRHSPASR
HHHHHCCCCCCCHHH		37.0721712546
1071PhosphorylationLLTPSRHSPASRIPP
HHCCCCCCCHHHCCC		22.5021712546
1074PhosphorylationPSRHSPASRIPPPEL
CCCCCCHHHCCCCCC		33.8426055452
1092PhosphorylationLPPPARRSPMDSLLH
CCCCCCCCCCHHHCC		21.0126055452
1096PhosphorylationARRSPMDSLLHPRER
CCCCCCHHHCCCCCC		26.9523186163
1134PhosphorylationSNLSLRRSSERLSDT
CHHHHHCCCCCCCCC		30.07-
1139PhosphorylationRRSSERLSDTPGSFQ
HCCCCCCCCCCCCCC		45.7324275569
1208PhosphorylationQTLDSRPSVPSPKSA
EECCCCCCCCCCCCC		45.6230266825
1211PhosphorylationDSRPSVPSPKSAGAS
CCCCCCCCCCCCCCC		42.6924719451
1221UbiquitinationSAGASGSKDAPVPGG
CCCCCCCCCCCCCCC		62.5329967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DEN4B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DEN4B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DEN4B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DEN4B_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DEN4B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-736, AND MASSSPECTROMETRY.

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