DEN2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEN2A_HUMAN
• UniProt AC: Q9ULE3
• Protein Name: DENN domain-containing protein 2A
• Gene Name: DENND2A
• Organism: Homo sapiens (Human).
• Sequence Length: 1009
• Subcellular Localization: Cytoplasm, cytoskeleton . Associated with actin filaments.
• Protein Description: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport..
• Protein Sequence: MDMFSLDMIISDPAAEASRAGKKQLRGVQNPCPSARARPRHKSLNIKDKISEWEGKKEVPTPAPSRRADGQEDYLPSSTVERRSSDGVRTQVTEAKNGMRPGTESTEKERNKGAVNVGGQDPEPGQDLSQPEREVDPSWGRGREPRLGKLRFQNDPLSVLKQVKKLEQALKDGSAGLDPQLPGTCYSPHCPPDKAEAGSTLPENLGGGSGSEVSQRVHPSDLEGREPTPELVEDRKGSCRRPWDRSLENVYRGSEGSPTKPFINPLPKPRRTFKHAGEGDKDGKPGIGFRKEKRNLPPLPSLPPPPLPSSPPPSSVNRRLWTGRQKSSADHRKSYEFEDLLQSSSESSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDIELHGRCLGKKCVLNFPASPTSSIPDTLTKQSLSKPAFFRQNSERRNFKLLDTRKLSRDGTGSPSKISPPSTPSSPDDIFFNLGDPQNGRKKRKIPKLVLRINAIYEVRRGKKRVKRLSQSMESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYPSLARELIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	RARPRHKSLNIKDKI CCCCCCCCCCHHHHH	22.11	24702127
61	Phosphorylation	EGKKEVPTPAPSRRA CCCCCCCCCCCCCCC	36.94	23403867
65	Phosphorylation	EVPTPAPSRRADGQE CCCCCCCCCCCCCCC	36.18	23403867
74	Phosphorylation	RADGQEDYLPSSTVE CCCCCCCCCCCCCEE	21.54	24927040
77	Phosphorylation	GQEDYLPSSTVERRS CCCCCCCCCCEEEEC	35.73	23403867
78	Phosphorylation	QEDYLPSSTVERRSS CCCCCCCCCEEEECC	34.24	23403867
84	Phosphorylation	SSTVERRSSDGVRTQ CCCEEEECCCCCCHH	38.72	26699800
85	Phosphorylation	STVERRSSDGVRTQV CCEEEECCCCCCHHH	36.25	26699800
174	Phosphorylation	EQALKDGSAGLDPQL HHHHHHCCCCCCCCC	29.33	-
184	Phosphorylation	LDPQLPGTCYSPHCP CCCCCCCCCCCCCCC	13.31	-
228	Phosphorylation	DLEGREPTPELVEDR HCCCCCCCHHHHCCC	25.33	28978645
246	Phosphorylation	CRRPWDRSLENVYRG CCCCCCCCHHHHHCC	37.25	26657352
251	Phosphorylation	DRSLENVYRGSEGSP CCCHHHHHCCCCCCC	22.34	27642862
254	Phosphorylation	LENVYRGSEGSPTKP HHHHHCCCCCCCCCC	29.77	23312004
257	Phosphorylation	VYRGSEGSPTKPFIN HHCCCCCCCCCCCCC	25.91	22210691
259	Phosphorylation	RGSEGSPTKPFINPL CCCCCCCCCCCCCCC	53.71	22210691
309	Phosphorylation	LPPPPLPSSPPPSSV CCCCCCCCCCCCCHH	64.26	27251275
310	Phosphorylation	PPPPLPSSPPPSSVN CCCCCCCCCCCCHHC	39.21	26657352
334	Phosphorylation	SSADHRKSYEFEDLL CCCCHHHHHCHHHHH	29.83	22199227
335	Phosphorylation	SADHRKSYEFEDLLQ CCCHHHHHCHHHHHH	27.89	27642862
343	Phosphorylation	EFEDLLQSSSESSRV CHHHHHHCCCCCCCC	35.48	27642862
353	Phosphorylation	ESSRVDWYAQTKLGL CCCCCHHHHHHHHCC	5.60	25884760
361	Phosphorylation	AQTKLGLTRTLSEEN HHHHHCCCCCCCCCC	21.58	29514088
363	Phosphorylation	TKLGLTRTLSEENVY HHHCCCCCCCCCCCC	29.42	26657352
365	Phosphorylation	LGLTRTLSEENVYED HCCCCCCCCCCCCHH	42.10	26657352
370	Phosphorylation	TLSEENVYEDILDPP CCCCCCCCHHHCCCC	21.33	29514088
383	Phosphorylation	PPMKENPYEDIELHG CCCCCCCCHHHEEEC	37.50	24927040
404	Phosphorylation	CVLNFPASPTSSIPD EEEECCCCCCCCCCC	29.02	23663014
406	Phosphorylation	LNFPASPTSSIPDTL EECCCCCCCCCCCCC	32.39	23663014
407	Phosphorylation	NFPASPTSSIPDTLT ECCCCCCCCCCCCCC	29.65	23663014
408	Phosphorylation	FPASPTSSIPDTLTK CCCCCCCCCCCCCCC	40.39	23663014
412	Phosphorylation	PTSSIPDTLTKQSLS CCCCCCCCCCCCCCC	30.85	23663014
414	Phosphorylation	SSIPDTLTKQSLSKP CCCCCCCCCCCCCCC	29.18	23663014
417	Phosphorylation	PDTLTKQSLSKPAFF CCCCCCCCCCCCCHH	35.85	23663014
419	Phosphorylation	TLTKQSLSKPAFFRQ CCCCCCCCCCCHHCC	41.67	23663014
428	Phosphorylation	PAFFRQNSERRNFKL CCHHCCCCCCCCEEE	24.92	29514088
491	Phosphorylation	VLRINAIYEVRRGKK HHHHHHHHHHHCCHH	13.13	27642862
504	Phosphorylation	KKRVKRLSQSMESNS HHHHHHHHHHHHHCC	25.00	26657352
506	Phosphorylation	RVKRLSQSMESNSGK HHHHHHHHHHHCCCC	22.57	29514088
509	Phosphorylation	RLSQSMESNSGKVTD HHHHHHHHCCCCCCC	27.88	23403867
511	Phosphorylation	SQSMESNSGKVTDEN HHHHHHCCCCCCCCC	49.63	23403867
519	Phosphorylation	GKVTDENSESDSDTE CCCCCCCCCCCCCHH	36.11	24114839
521	Phosphorylation	VTDENSESDSDTEEK CCCCCCCCCCCHHHH	42.08	24114839
523	Phosphorylation	DENSESDSDTEEKLK CCCCCCCCCHHHHHH	56.57	24114839
551	Phosphorylation	KQAPRYPSLARELIE HHCCCCHHHHHHHHH	26.23	-
723	Phosphorylation	VKNFLPGSGTEVIEL EEECCCCCCCHHHHH	40.37	28796482
725	Phosphorylation	NFLPGSGTEVIELCR ECCCCCCCHHHHHHC	28.86	28796482
736	Phosphorylation	ELCRPLDSRLEHVDF HHHCCCCCCCCCCCH	46.58	28796482
751	Phosphorylation	ESLFSSLSVRHLVCV HHHHHHCHHHHHHHH	21.03	24719451
776	Phosphorylation	IFIADKLSILSKCCH HHHHHHHHHHHHHHH	27.50	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEN2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEN2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEN2A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DEN2A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.