DEK_MOUSE - dbPTM
DEK_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DEK_MOUSE
UniProt AC Q7TNV0
Protein Name Protein DEK
Gene Name Dek
Organism Mus musculus (Mouse).
Sequence Length 380
Subcellular Localization Nucleus . Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei..
Protein Description Involved in chromatin organization..
Protein Sequence MSAAAAPAAEGEDAPVPPSSEKEPEMPGPREESEEEEEDDEDDDEEDEEEEKEKSLIVEGKREKKKVERLTMQVSSLQREPFTVTQGKGQKLCEIERIHFFLSKKKPDELRNLHKLLYNRPGTVSSLKKNVGQFSGFPFEKGSTQYKKKEEMLKKFRNAMLKSICEVLDLERSGVNSELVKRILNFLMHPKPSGKPLPKSKKSSSKGSKKERNSSGTTRKSKQTKCPEILSDESSSDEDEKKNKEESSEDEEKESEEEQPPKKTSKKEKAKQKATAKSKKSVKSANVKKADSSTTKKNQKSSKKESESEDSSDDEPLIKKLKKPPTDEELKETVKKLLADANLEEVTMKQICKEVYENYPAYDLTERKDFIKTTVKELIS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationEDAPVPPSSEKEPEM
CCCCCCCCCCCCCCC		45.0925338131
20PhosphorylationDAPVPPSSEKEPEMP
CCCCCCCCCCCCCCC		59.46-
33PhosphorylationMPGPREESEEEEEDD
CCCCCCCCCCHHCCC		45.6225521595
55PhosphorylationEEEEKEKSLIVEGKR
HHHHHHHHHEECCHH		25.1526824392
61AcetylationKSLIVEGKREKKKVE
HHHEECCHHHHHHHH		43.837666161
71PhosphorylationKKKVERLTMQVSSLQ
HHHHHHHHHHHHHCC		16.2729899451
75PhosphorylationERLTMQVSSLQREPF
HHHHHHHHHCCCCCE		14.4027149854
76PhosphorylationRLTMQVSSLQREPFT
HHHHHHHHCCCCCEE		29.6629176673
93GlutathionylationQGKGQKLCEIERIHF
CCCCCEEEEEEEEEE		6.7924333276
125PhosphorylationYNRPGTVSSLKKNVG
HCCCCCHHHHHHCCC		29.7729176673
126PhosphorylationNRPGTVSSLKKNVGQ
CCCCCHHHHHHCCCC		39.6129176673
163PhosphorylationFRNAMLKSICEVLDL
HHHHHHHHHHHHHCH		28.63-
165S-nitrosylationNAMLKSICEVLDLER
HHHHHHHHHHHCHHH		3.6920925432
165S-nitrosocysteineNAMLKSICEVLDLER
HHHHHHHHHHHCHHH		3.69-
173PhosphorylationEVLDLERSGVNSELV
HHHCHHHCCCCHHHH		37.4022942356
201AcetylationGKPLPKSKKSSSKGS
CCCCCCCCCCCCCCC		63.9019860137
205PhosphorylationPKSKKSSSKGSKKER
CCCCCCCCCCCCCCC		48.39-
206AcetylationKSKKSSSKGSKKERN
CCCCCCCCCCCCCCC		69.9719859171
208PhosphorylationKKSSSKGSKKERNSS
CCCCCCCCCCCCCCC		44.27-
214PhosphorylationGSKKERNSSGTTRKS
CCCCCCCCCCCCCCC		36.04-
231PhosphorylationTKCPEILSDESSSDE
CCCCHHHCCCCCCHH		45.0227087446
234PhosphorylationPEILSDESSSDEDEK
CHHHCCCCCCHHHHH		39.8827087446
235PhosphorylationEILSDESSSDEDEKK
HHHCCCCCCHHHHHH		39.5027087446
236PhosphorylationILSDESSSDEDEKKN
HHCCCCCCHHHHHHH		55.0627087446
247PhosphorylationEKKNKEESSEDEEKE
HHHHHHCCCHHHHHH		39.8727087446
248PhosphorylationKKNKEESSEDEEKES
HHHHHCCCHHHHHHC		52.9627087446
255PhosphorylationSEDEEKESEEEQPPK
CHHHHHHCHHCCCCC		62.4725521595
284ADP-ribosylationKSKKSVKSANVKKAD
HCHHHHHHHCCCCCC		23.95-
292PhosphorylationANVKKADSSTTKKNQ
HCCCCCCCCCCHHCH		34.15-
293PhosphorylationNVKKADSSTTKKNQK
CCCCCCCCCCHHCHH		40.41-
294PhosphorylationVKKADSSTTKKNQKS
CCCCCCCCCHHCHHC		46.73-
295PhosphorylationKKADSSTTKKNQKSS
CCCCCCCCHHCHHCC		41.80-
301PhosphorylationTTKKNQKSSKKESES
CCHHCHHCCCCCCCC		37.3122324799
302PhosphorylationTKKNQKSSKKESESE
CHHCHHCCCCCCCCC		55.5722324799
306PhosphorylationQKSSKKESESEDSSD
HHCCCCCCCCCCCCC		56.1327087446
308PhosphorylationSSKKESESEDSSDDE
CCCCCCCCCCCCCCH		56.8527087446
311PhosphorylationKESESEDSSDDEPLI
CCCCCCCCCCCHHHH		31.4527087446
312PhosphorylationESESEDSSDDEPLIK
CCCCCCCCCCHHHHH		62.4927087446
333PhosphorylationTDEELKETVKKLLAD
CHHHHHHHHHHHHHC		35.72-
336UbiquitinationELKETVKKLLADANL
HHHHHHHHHHHCCCH		44.3822790023
347PhosphorylationDANLEEVTMKQICKE
CCCHHHHCHHHHHHH		23.18-
356PhosphorylationKQICKEVYENYPAYD
HHHHHHHHHHCCCCC		10.27-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DEK_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DEK_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DEK_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DEK_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DEK_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231; SER-234; SER-235;SER-236; SER-247; SER-248; SER-306; SER-308; SER-311 AND SER-312, ANDMASS SPECTROMETRY.
"A differential phosphoproteomic analysis of retinoic acid-treated P19cells.";
Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.;
J. Proteome Res. 6:3174-3186(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247; SER-248; SER-255;SER-306; SER-308; SER-311 AND SER-312, AND MASS SPECTROMETRY.

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