DEAF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEAF1_MOUSE
• UniProt AC: Q9Z1T5
• Protein Name: Deformed epidermal autoregulatory factor 1 homolog
• Gene Name: Deaf1
• Organism: Mus musculus (Mouse).
• Sequence Length: 566
• Subcellular Localization: Isoform 1: Nucleus. Cytoplasm.; Isoform 2: Cytoplasm. Nucleus. Displays some nuclear localization when expressed with isoform 1, suggesting that it may heterodimerize with isoform 1 and shuttle to the nucleus using the nuclear localization signal of
• Protein Description: Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction (By similarity). Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 2. Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm. Transcriptional activator of EIF4G3 (By similarity). May also involved in behavior. [PubMed: 24726472]
• Protein Sequence: MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAESEAEEPVLSRDEDSEEDADSEAERETRRVTAVAVMAAESGHMDMGTEALPSPDEAAAAAAAFAEVTTVTVANVGSSADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEAGVQPPCRVGHPEPHYPGYQDSCQIAPFPEAALPTSHPKIVLTSLPALAVPPSTPTKAVSPTVVSGLEMSEHRSWLYLEEMVNSLLNTAQQLKTLFEQAKQASSCREAAVTQARMQVDTERKEQSCVNCGREAMSECTGCHKVNYCSTFCQRKDWKDHQHVCGQSASVTVQADDVHVEESVIEKVAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	AAAAAAESEAEEPVL HHHHHHHHHCCCCCC	37.06	26239621
43	Phosphorylation	EAEEPVLSRDEDSEE HCCCCCCCCCCCCHH	37.61	26239621
48	Phosphorylation	VLSRDEDSEEDADSE CCCCCCCCHHHCCHH	40.62	25521595
54	Phosphorylation	DSEEDADSEAERETR CCHHHCCHHHHHHHH	40.19	25521595
172	Phosphorylation	KGPAAPLTPGPQSPP CCCCCCCCCCCCCCC	25.74	22942356
177	Phosphorylation	PLTPGPQSPPTPLAP CCCCCCCCCCCCCCC	35.66	26824392
180	Phosphorylation	PGPQSPPTPLAPGQE CCCCCCCCCCCCCCC	34.03	28833060
212	Phosphorylation	PVRCRNISGTLYKSR CCEEEECCCCEEECC	29.31	26745281
214	Phosphorylation	RCRNISGTLYKSRLG EEEECCCCEEECCCC	21.81	28833060
218	Phosphorylation	ISGTLYKSRLGSGGR CCCCEEECCCCCCCC	21.12	22817900
222	Phosphorylation	LYKSRLGSGGRGRCI EEECCCCCCCCCCCC	42.54	22817900
312	Phosphorylation	KKENELPTTPVKKDS CCCCCCCCCCCCCCC	57.25	28066266
313	Phosphorylation	KENELPTTPVKKDSP CCCCCCCCCCCCCCC	24.93	25266776
319	Phosphorylation	TTPVKKDSPKNITLL CCCCCCCCCCCEEEE	46.80	29514104
432	Phosphorylation	PALAVPPSTPTKAVS CEECCCCCCCCCCCC	40.73	25266776
433	Phosphorylation	ALAVPPSTPTKAVSP EECCCCCCCCCCCCC	40.53	26745281
435	Phosphorylation	AVPPSTPTKAVSPTV CCCCCCCCCCCCCCC	31.55	25266776
439	Phosphorylation	STPTKAVSPTVVSGL CCCCCCCCCCCCCCC	21.51	28833060
441	Phosphorylation	PTKAVSPTVVSGLEM CCCCCCCCCCCCCCC	26.49	28833060
444	Phosphorylation	AVSPTVVSGLEMSEH CCCCCCCCCCCCCCC	33.07	28066266
449	Phosphorylation	VVSGLEMSEHRSWLY CCCCCCCCCCHHHHH	22.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEAF1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEAF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEAF1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DEAF1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.