DDX46_MOUSE - dbPTM
DDX46_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DDX46_MOUSE
UniProt AC Q569Z5
Protein Name Probable ATP-dependent RNA helicase DDX46
Gene Name Ddx46
Organism Mus musculus (Mouse).
Sequence Length 1032
Subcellular Localization Nucleus speckle. Nucleus, Cajal body. Membrane
Lipid-anchor . Present in Cajal bodies (CBs) and nuclear speckles..
Protein Description Plays an essential role in splicing, either prior to, or during A complex formation..
Protein Sequence MGRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGSKTKKTENRSRSKEKAEGGDSSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGTEMEDEELDPLDAYMEEVKEEVKKFNMRSVKGGAGNEKKSGPTVTKVVTVVTTKKAVVDADKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPLEKQEEERQEGGQSESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSYQPTNKGRYKVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Myristoylation------MGRESRHYR
------CCCCCHHHH		54.06-
20PhosphorylationASRGRSGSRSRSRSP
HCCCCCCCCCCCCCC		28.4722871156
102PhosphorylationSRSRGRRSRSSSPGS
HHHHCCCCCCCCCCC		34.8427087446
104PhosphorylationSRGRRSRSSSPGSKT
HHCCCCCCCCCCCCC		36.0927087446
105PhosphorylationRGRRSRSSSPGSKTK
HCCCCCCCCCCCCCC		39.1727087446
106PhosphorylationGRRSRSSSPGSKTKK
CCCCCCCCCCCCCCC		34.2327087446
199PhosphorylationMKQGKKWSLEDDDDD
HHCCCCCCCCCCCCC		30.6621149613
218PhosphorylationAEAEKEGTEMEDEEL
HHHHHHCCCCCCCCC		33.0025777480
231PhosphorylationELDPLDAYMEEVKEE
CCCHHHHHHHHHHHH		12.5325777480
263AcetylationKSGPTVTKVVTVVTT
CCCCEEEEEEEEEEC		30.30-
272AcetylationVTVVTTKKAVVDADK
EEEEECCEEEEECCH		44.30412439249
294PhosphorylationNDQDAMEYSSEEEEV
CCCCHHHCCCHHHHH		12.3828833060
295PhosphorylationDQDAMEYSSEEEEVD
CCCHHHCCCHHHHHH		20.2618388127
296PhosphorylationQDAMEYSSEEEEVDL
CCHHHCCCHHHHHHH		48.3918388127
305PhosphorylationEEEVDLQTALTGYQT
HHHHHHHHHHHHHHH		30.8228833060
308PhosphorylationVDLQTALTGYQTKQR
HHHHHHHHHHHHHHC		31.2328833060
310PhosphorylationLQTALTGYQTKQRKL
HHHHHHHHHHHHCCC		14.0528833060
312PhosphorylationTALTGYQTKQRKLLE
HHHHHHHHHHCCCCC		22.2128833060
344AcetylationVEVPELAKMSQEEVN
EEHHHHHHCCHHHHC		52.27412439237
346PhosphorylationVPELAKMSQEEVNVF
HHHHHHCCHHHHCEE		33.46-
361PhosphorylationRLEMEGITVKGKGCP
EEEEECEEECCCCCC		27.3325159016
363AcetylationEMEGITVKGKGCPKP
EEECEEECCCCCCCC		46.37412439245
394AcetylationLKKHGYEKPTPIQTQ
HHHCCCCCCCCCCCC		45.79412439239
470AcetylationKECKKFSKTLGLRVV
HHHHHHHCHHCCEEE		51.40412439213
514PhosphorylationIDMLAANSGRVTNLR
HHHHHHCCCCCCCCC		24.2129109428
716AcetylationRTGRAGNKGYAYTFI
CCCCCCCCCEEEEEE		52.99412439235
776AcetylationKSSGFSGKGFKFDET
CCCCCCCCCCCCCHH		61.0423806337
779AcetylationGFSGKGFKFDETEQA
CCCCCCCCCCHHHHH		61.6523806337
799 (in isoform 2)Phosphorylation-9.3319144319
804PhosphorylationAALGLQDSDDEDAAV
HHHCCCCCCCHHHCC		33.7224925903
819PhosphorylationDIDEQIESMFNSKKR
CHHHHHHHHHCCCHH		30.2425619855
823PhosphorylationQIESMFNSKKRVKDM
HHHHHHCCCHHHHHC		28.4325619855
848AcetylationPTAGNAEKLEIAKRL
CCCCCHHHHHHHHHH		49.3522826441
886PhosphorylationNAILRGGTILAPTVS
HHHHCCCCEECCCCC		18.6829176673
895AcetylationLAPTVSAKTIAEQLA
ECCCCCHHHHHHHHH		32.7222826441
895UbiquitinationLAPTVSAKTIAEQLA
ECCCCCHHHHHHHHH		32.7222790023
904AcetylationIAEQLAEKINAKLNY
HHHHHHHHHHHHHCC		35.3423806337
904UbiquitinationIAEQLAEKINAKLNY
HHHHHHHHHHHHHCC		35.3422790023
908AcetylationLAEKINAKLNYVPLE
HHHHHHHHHCCCCHH		32.5522826441
929PhosphorylationQEGGQSESFKRYEEE
HCCCCCHHHHHHHHH		41.12-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DDX46_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DDX46_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DDX46_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DDX46_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DDX46_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-804, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory