| UniProt ID | DDX25_HUMAN | |
|---|---|---|
| UniProt AC | Q9UHL0 | |
| Protein Name | ATP-dependent RNA helicase DDX25 | |
| Gene Name | DDX25 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 483 | |
| Subcellular Localization | Cytoplasm . Nucleus. Detected in both cytoplasm and nucleus of testicular cells. Also detected in chromatoid bodies of round spermatids (By similarity).. | |
| Protein Description | ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity).. | |
| Protein Sequence | MASLLWGGDAGAAESERLNSHFSNLSQPRKNLWGIKSTAVRNIDGSINNINEDDEEDVVDLAANSLLNKLIHQSLVESSHRVEVLQKDPSSPLYSVKTFEELRLKEELLKGIYAMGFNRPSKIQEMALPMMLAHPPQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVEQMGKFCVDVQVMYAIRGNRIPRGTDITKQIIIGTPGTVLDWCFKLKLIDLTKIRVFVLDEADVMIDTQGFSDHSIRIQRALPSECQMLLFSATFEDSVWHFAERIIPDPNVIKLRKEELTLNNIRQYYVLCEHRKDKYQALCNIYGSITIGQAIIFCQTRRNAKWLTVEMIQDGHQVSLLSGELTVEQRASIIQRFRDGKEKVLITTNVCARGIDVKQVTIVVNFDLPVKQGEEPDYETYLHRIGRTGRFGKKGLAFNMIEVDELPSLMKIQDHFNSSIKQLNAEDMDEIEKIDY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Phosphorylation | NSHFSNLSQPRKNLW HHHCCCCCCCCCCCC | 42.25 | 24719451 | |
| 30 | Ubiquitination | SNLSQPRKNLWGIKS CCCCCCCCCCCCCHH | 64.18 | - | |
| 36 | Ubiquitination | RKNLWGIKSTAVRNI CCCCCCCHHHEEECC | 37.50 | - | |
| 65 | Phosphorylation | VVDLAANSLLNKLIH HHHHHHHHHHHHHHH | 29.52 | 24719451 | |
| 69 | Ubiquitination | AANSLLNKLIHQSLV HHHHHHHHHHHHHHH | 49.11 | - | |
| 87 | Ubiquitination | HRVEVLQKDPSSPLY CCEEEECCCCCCCCC | 68.40 | - | |
| 97 | Ubiquitination | SSPLYSVKTFEELRL CCCCCCCCCHHHHHH | 41.37 | - | |
| 105 | Ubiquitination | TFEELRLKEELLKGI CHHHHHHHHHHHHHH | 42.58 | - | |
| 113 | Phosphorylation | EELLKGIYAMGFNRP HHHHHHHHHCCCCCC | 10.13 | - | |
| 150 | Phosphorylation | SQSGTGKTAAFVLAM CCCCCCHHHHHHHHH | 25.27 | 20860994 | |
| 212 | Phosphorylation | GNRIPRGTDITKQII CCCCCCCCCCCCEEE | 26.05 | 22985185 | |
| 239 | Phosphorylation | KLKLIDLTKIRVFVL HHHCCCCCEEEEEEE | 22.22 | - | |
| 304 | Ubiquitination | PNVIKLRKEELTLNN CCCEEECHHHCCCCH | 67.01 | - | |
| 366 | Phosphorylation | IQDGHQVSLLSGELT ECCCCCEEEEEEECC | 19.61 | 20044836 | |
| 369 | Phosphorylation | GHQVSLLSGELTVEQ CCCEEEEEEECCHHH | 35.20 | 20044836 | |
| 468 | Ubiquitination | DHFNSSIKQLNAEDM HHHHHHHHHCCHHHH | 51.16 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DDX25_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DDX25_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DDX25_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of DDX25_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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