DDB1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDB1_DROME
• UniProt AC: Q9XYZ5
• Protein Name: DNA damage-binding protein 1
• Gene Name: pic
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1140
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Required for degradation of gig. Required for genomic stability in the face of endogenous DNA lesions and for the response to MMS-induced DNA damage. Required for normal wing development..
• Protein Sequence: MSHHYVVTAQKPTAVVACLTGNFTSPTDLNLIIARNNQVEIDLVTPEGLRPLKEININGTIAVMRHFRPPDSNKDLLFILTRRYNVMILEARMVNDVITVVTKANGNVSDSVGIPSEGGVIAAIDPKARVIGMCLYQGLFTIIPMDKDASELKATNLRMDELNVYDVEFLHGCLNPTVIVIHKDSDGRHVKSHEINLRDKEFMKIAWKQDNVETEATMLIPVPSPIGGVIVIGRESIVYHDGSNYHAVAPLTFRQSTINCYARVSSNGLRYLLGNMDGQLYMLFLGTAETSKGVTVKDIKVEQLGEISIPECITYLDNGFLYIGARHGDSQLVRLNSEAIDGSYVVPVENFTNLAPILDIAVVDLDRQGQGQIITCSGSFKDGSLRIIRIGIGIQEHACIDLPGIKGMWSLKVGVDESPYENTLVLAFVGHTRILTLSGEEVEETEIPGFASDLQTFLCSNVDYDQLIQVTSDSVRLVSSATKALVAEWRPTGDRTIGVVSCNTTQILVASACDIFYIVIEDGSLREQSRRTLAYEVACLDITPLDETQKKSDLVAVGLWTDISAVILSLPDLETIYTEKLSGEIIPRSILMTTFEGIHYLLCALGDGSMYYFIMDQTTGQLTDKKKVTLGTQPTTLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNHMCSLNAQAYPDSLALANKNAVILGTIDEIQKLHIRTVPLGEGPRRIAYQESSQTFAVSTLRIDVHGRGGAKPLRNSASTQAQNITCSSNFLPKPGGGNSTAANAEVGQEIDVHNLLVIDQNTFEVLHAHQFVAPETISSLMSAKLGDDPNTYYVVATSLVIPEEPEPKVGRIIIFHYHENKLTQVAETKVDGTCYALVEFNGKVLAGIGSFVRLYEWTNEKELRMECNIQNMIAALFLKAKGDFILVGDLMRSITLLQHKQMEGIFVEIARDCEPKWMRAVEILDDDTFLGSETNGNLFVCQKDSAATTDEERQLLPELARFHLGDTVNVFRHGSLVMQNVGERTTPINGCVLYGTCNGAIGIVTQIPQDFYDFLHGLEERLKKIIKSVGKIEHTYYRNFQINSKVEPSEGFIDGDLIESFLDLSRDKMRDAVQGLELTLNGERKSADVEDVIKIVEDLTRMH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
644	Phosphorylation	LRTFRSLSTTNVFAC HHHCCCCCCCCEEEE	34.14	21082442
1012	Phosphorylation	VNVFRHGSLVMQNVG EEEECCCCEEECCCC	16.21	21082442
1097	Phosphorylation	IDGDLIESFLDLSRD CCHHHHHHHHHHCHH	24.90	19429919
1102	Phosphorylation	IESFLDLSRDKMRDA HHHHHHHCHHHHHHH	37.79	19429919
1123	Phosphorylation	TLNGERKSADVEDVI EECCCCCCCCHHHHH	35.60	27626673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDB1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDB1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDB1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.